[1.1] - Bifidobacterium can resist the antimicrobial activity of bile salts.
[1.2] [#Autism] [#Short Chain Fatty Acid] - The reduction of Bifidobacterium also results in reduced levels of short-chain fatty acids (SCFAs), common in ASD children.
[1.3] [#Cancer] - Bifidobacterium is associated with antitumor effects, and oral administration of Bifidobacterium alone improved tumor control to the same degree as PD-L1 antibody therapy while combination treatment nearly abolished tumor growth in mice.
[1.4] [#Biliary tract cancer] [#Plant-based diet] - High levels of plant dietary fibers in the gut resulted in proliferation of Bifidobacterium with anti-inflammatory and anti-tumor effects
[1.5] - Bifidobacterium species decrease #Cancer cell proliferation via the inhibition of growth factor signaling as well as inducing mitochondrial-mediated apoptosis.
- Bifidobacterium species reduce the adverse effects of chemo/immuno/radiation therapy by inhibiting proinflammatory cytokines.
[1.6] [#Diabetes Type 2] - Bifidobacterium appears to be the most consistently supported by the literature genus containing microbes potentially protective against T2D
[1.9] [#Cancer] [#High salt diet] - HSD increased the abundance of Bifidobacterium and caused increased gut permeability leading to intratumor localization of Bifidobacterium, which enhanced NK cell functions and tumor regression.
- Intratumoral injections of Bifidobacterium activated NK cells, which inhibited tumor growth.
- Bifidobacterium breve have a positive correlation with acetic acid levels and intestinal epithelium expression of tight junction-related genes.
[1.12] - “Bifidobacterium” pattern > increaseds #Sleep Activity at 12 months.
- “Bifidobacterium” enterotype > infants with more nighttime awakenings.
[1.13] [#Exercise training] - Exercise increases > increase α-diversity and microbial metabolites such as SCFAs.
- Exercise > typically reveal increases in commensal taxa such as Bifidobacterium, #Lactobacilli, and #Akkermansia
[1.14] [#Lactoferrin] - LF > iron donor to support the growth of some bacteria with lower iron demands > #Lactobacillus sp. or Bifidobacterium sp.
[1.15] [#Lachnospiraceae] - 4 weeks of #Grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing #Verrucomicrobia at the phylum level, and a significant increase in #Akkermansia and increase in #Flavonifractor and Lachnospiraceae_UCG-010 > decrease in Bifidobacterium and #Dialister at the genus level.
[1.16] [#Chronic fatigue syndrome] - MC/CFS > microbiome alterations that were consistent with an increased inflammation of the gut, namely significantly increased #Lactonifactor and #Alistipes
- in particular an increase of #Alistipes and a decrease of butyrate-producer #Faecalibacterium were considered as top biomarkers with potential diagnostic value
- abundance of Bifidobacterium and #Faecalibacterium to be reduced in the affected twin compared to the non-affected one.
- Decreases in #Faecalibacterium and increases in #Coprobacillus were found.
- Gut abundances of #Coprobacillus, of #Eggerthella and #Blautia were best able to distinguish patients from controls.
- Decreases in #Faecalibacterium and increases in #Coprobacillus were found.
- distinct microbial pattern with decreased anti-inflammatory #Firmicutes
[1.17] - Barley contains abundant soluble #Beta-glucan fibers
- Bifidobacterium, #Butyricicoccus, #Collinsella, #Ruminococcus 2, and #Dialister were characteristic candidate bacterias of the group that consumed large amounts of barley.
- The relationship between #Barley consumption and Bifidobacterium remained after adjusting for disease and dietary habits, and that of #Butyricicoccus remained after adjusting for disease.
- Network and cluster analyses revealed that #Barley consumption was directly correlated with Bifidobacterium and #Butyricicoccus.
[1.18] - the abundance of oral Bifidobacterium was negatively associated with plasma concentrations of known #Covid-19 biomarkers interleukin 17F (IL-17F) and monocyte chemoattractant protein-1 (MCP-1)
[#High fibre diet] - vegetables rich in #Inulin increased Bifidobacterium levels, promoted satiety, and reduced body weight
[1.21] [#Inflamatory bowel disease] - studies have demonstrated striking differences between luminal and mucosal samples within the colon itself, specifically regarding mucosa-associated bacteria such as Bifidobacterium, #Lactobacillus, and #Akkermansia.
- the microbial community composition is different between ileal luminal samples from colonic and fecal samples, as well along the length of the colon itself.
[1.22] [#Bifidobacterium breve] - in pregnant women, Bifidobacterium represents a key beneficial microbiota genus, with levels observed to increase across #Pregnancy.
- using germ-free and specific-pathogen-free mice, we demonstrate that the bacterium Bifidobacterium breve UCC2003 modulates maternal body adaptations, placental structure and nutrient transporter capacity, with implications for fetal metabolism and growth
[1.23] [#Inulin] [#Inulin] - LCI is associated with an increase in Bifidobacterium.
[1.24] - #Allicin (diallylthiosulfinate) is a natural food compound with multiple biological and pharmacological functions.
- #Allicin treatment significantly improved GM composition and induced the most significant alteration enrichment of Bifidobacterium and #Lactobacillus.
- #Allicin-induced GM to HFD mice (AGMT) significantly increased Blautia [short-chain fatty acids (SCFAs)-producing microbiota] and Bifidobacterium in HFD mice, also increased the SCFAs in the cecum,
[1.25] [#Inflamatory bowel disease, #Systemic anti-microbiota IgG] - a modified high-throughput, culture-independent approach to quantify systemic IgG against gut commensal bacteria in human serum samples without the need for paired stool samples.
- Using this approach, we highlight several commensal bacterial species that elicit elevated IgG responses in patients with inflammatory bowel disease (IBD) including taxa within the clades #Collinsella, Bifidobacterium, #Lachnospiraceae, and #Ruminococcaceae.
[1.26] [#Asthma] [#Children] - low α-diversity and relative abundance of particular gut-commensal bacteria genera (Bifidobacterium, #Faecalibacterium, #Ruminococcus, and #Roseburia) are associated with childhood respiratory diseases.
[#High fibre plant protein-rich diet] - Bifidobacterium spp. was in direct correlation with intake of dietary protein such as vegetable protein and fibre specifically soluble one which are found in green vegetables like beans, broccoli, asparagus, peas and Brussels sprouts.
[#Culinary herbs and spices] - six of seven aqueous culinary spice extracts of oregano, ginger, rosemary, cinnamon, black pepper and cayenne pepper were able to promote the growth of Bifidobacterium spp. in vitro, whereas turmeric was not.
- stimulation of #Lactobacillus spp. and inhibition of certain #Clostridium spp. by all seven spices.
- increase in most #Clostridium spp. after turmeric and curcumin intervention in a human study.
- high consumption compared to low consumption of #Cocoa derived flavanols, significantly stimulated growth of Bifidobacterium spp. and #Lactobacillus spp.
[#Obesity] - #Acetic acid, a product of Bifidobacterium spp. known to function as an appetite suppressant, was found to be most abundant in the faeces of mice following #Ginger supplementation.
[1.31] [#Autism] - The depletion of Bifidobacterium species has been reported widely in ASD.
- #Bifidobacteria are SCFA producers, and “psychobiotics” , and they modulate the gut–brain signals via γ-aminobutyric acid (GABA) and #Glutamate metabolism.
- Bifidobacterium have been reported to improve behavior and prevent #Depression-like behaviors in mice.
[#Autism] - lower levels of #Prevotella and Bifidobacterium may lead to reduced levels of #Folate production due to diminished #Folate-dependent remethylation in ASD
[1.32] [#Parkinson’s Disease] - Bifidobacterium and #Lactobacillus species, which are common constituents of commercial probiotics, were more abundant in PD than NHC metagenomes.
[1.33] [#Alzheimer’s disease] - AD > A positive correlation between the pro-inflammatory cytokines and Escherichia/Shigella (pro-inflammatory taxon) and a negative correlation with #Eubacterium rectale (anti-inflammatory taxon).
- a decrease in #Firmicutes and Bifidobacterium and increased levels of #Proteobacteria, #Actinobacteria
- a disputed frequency of #Bacteroidetes in various studies..
[#Infants] Greater proportions of #Palmitic acid in the pool of triacylglycerides, for instance > higher levels of fecal #Lactobacillus and Bifidobacterium in neonates.
[1.42] [#Anorexia nervosa] - In AN : The abundance of Bifidobacterium and #Parasutterella, in absolute terms, showed positive correlations with perfectionism and body dissatisfaction, respectively.
[1.44] [#Soybean] - high intake of milk and soy beverages was associated with a higher abundance of beneficial faecal microbes including #Faecalibacterium, Bifidobacterium, and #Parabacteroides.
- consumption of fermented soy milk was associated with increased abundance of Bifidobacterium, bifidobacteria and/or Lactobacillus compared to unfermented soy milk.
[1.45] [#CVD, #Obesity] [#Inulin-Type Fructans] - Addition of ITF to the #Plant-based diet reduced microbial diversity and selectively increased Bifidobacterium and #Faecalibacterium. -- The change in the latter was significantly associated with higher values of insulin and HOMA-IR and lower HDL #Cholesterol.
- The LDL:HDL ratio and the concentrations of IL-10, MCP-1 and TNFα were significantly elevated in the ITF-subgroup.
[1.47] [#Alzheimer’s disease] [#Olive] - #Lactobacilli and Bifidobacterium are often greatly reduced in patients with AD.
- Both of these bacterial types, populations of which are elevated with EVOO consumption, can produce γ-aminobutyric acid (#GABA), the main inhibitory neurotransmitter, likely influencing GABAergic firing in the brain via the enteric and vagal nervous systems.
- Extra-virgin #Olive oil ingestion in rodents also can promote the growth of certain types of beneficial #Bacteria including species of #Lactobacillus, Bifidobacterium, #Bacteroides, and #Clostridium, and members of the Erysipelotrichaeae.
[#Olive] - both the #Peanut oil and EVOO significantly increased the relative abundance of Bifidobacterium and reduced #Blautia levels and also had favorable effects on body weight, #Cholesterol levels, and insulin sensitivity.
[#Obesity] [#Olive] - in humans, EVOO has prebiotic effects, promoting the growth of beneficial bacteria such as #Lactobacillus and Bifidobacterium. Specifically, a #Mediterranean diet supplemented with 40 g/day EVOO for 3 months administered to 18 overweight/obese participants resulted in significantly increased levels of #Lactic acid bacteria compared to baseline.
[1.49] [#Human breast milk] - Lack of exclusive breastfeeding and early cessation is associated with reduced relative abundance of Bifidobacterium spp and lower stool levels of #Acetate.
[#Human breast milk, #Infants] - #Human milk oligosaccharides (HMOs) facilitate the expansion of Bifidobacterium species, which have an instrumental role in the development of T cell-dependent IgA responses and have been linked to higher numbers of memory B cells during infancy
[#Antibiotic Therapy, #Immune checkpoint inhibitor] - decrease in the abundance of Bifidobacterium members with antibiotics use was associated with impaired response to ICI targeting the programmed cell death protein 1 (anti-PD-1)
[#Atrial fibrillation] - possible negative association of prevalent AF with Bifidobacterium, and a positive relation for incident AF.
- In #Heart failure patients, the genus Bifidobacterium is depleted.
- Bifidobacterium has been positively correlated with ejection fraction and negatively with the cardiac stress marker N-terminal pro B-type natriuretic peptide.
[#Atrial fibrillation] - #Enorma, Bifidobacterium, and #Eisenbergiella were among the top associations of prevalent and incident AF.
- At the genera level, the top association of prevalent AF was observed with #Enorma.
- #Enorma belongs to the family of Coriobacteriaceae, which were among the core families related to #Heart failure
[1.61] [#Systemic lupus erythematosus] - Bifidobacterium can maintain the balance of Treg/Th17/Th1 by suppressing the excessive activation of CD4+ lymphocytes in SLE patients
[1.62] - #Plant protein intake correlates more closely with enrichment of some members of the Bifidobacterium genus.
[#Immune checkpoint inhibitor] - increased abundance of #Akkermansia muciniphila, #Phascolarctobacterium, Bifidobacterium and #Rothia in stool are consistently associated with better response to ICI treatment.
- A. muciniphila is also more abundant in stool in patients with higher muscle mass, and muscle mass is a strong positive prognostic marker in #Cancer, including after ICI treatment.
[1.63] [#Colorectal cancer] [#Short Chain Fatty Acid] [#Zizyphus jujuba cv. Muzao] -ZMP consumption prevented CRC mouse colon shortening, decreased their mortality, reduced pro-inflammatory cytokines, increased the concentration of total short-chain fatty acids (SCFAs) and modulated gut microbiota in their feces.
- ZMP also increased the richness of Bifidobacterium, #Bacteroides and #Lactobacillus.
[1.65] - Type 4 CST is characterized by having low levels of #Lactobacilli and high bacterial diversity.
- This type can result in vaginal dysbiosis, which may increase the risk of infections and health complications such as STIs and #Pelvic inflammatory disease.
- Not all Type 4 communities are harmful.
- Women can be asymptomatic or colonized with protective bacteria such as Bifidobacterium.
- Type 4 is further divided into three subtypes.
[1.66] - an increase of Bifidobacterium and #Eggerthella in #Infants who succeeded on at least one of the point and gaze subtests, while having a lower abundance of #Hungatella and #Streptococcus.
[1.67] [#Oat] - increase in Bifidobacterium and #Akkermansia, as well as a reduction in the #Sutterellaceae family when 80 g/d of oats were consumed as part of a normal diet for 45 days
[#Autism] - the levels of Bifidobacterium (known as beneficial bacteria, such as #Lactobacillus species) were significantly lower in the stool of #Children with ASD
- After probiotic supplementation, there was a significant increase in the colony counts of Bifidobacterium and #Lactobacillus with significant improvement in the severity of ASD and gastrointestinal symptoms.
[1.73] - Gut bacteria, specifically of the genera Bifidobacterium, #Clostridium, and #Lactobacillus, can produce enzymes such as β-glucuronidases that modify excreted estrogens, causing them to be retained in the body via reabsorption into circulation. This leads to increased #Estrogen levels which can cause several hormone-linked diseases.
[1.75] - Although 5-aminosalicylates affect the host gut pH and promote the growth of Bifidobacterium and #Lactobacillus, and #Wheat consumption has also been linked to their enrichment.
[#Genome] - In addition to Bifidobacterium and #Lactobacillus, our study found a significant enrichment of #Streptococcus, a #Lactic acid-producing bacteria, in patients with #Ulcerative Colitis (UC).
- This is in contrast to the majority of earlier studies from west.
- This increase in #Streptococcus abundance has also been observed in UC patients from different populations.
[#Ulcerative Colitis] - increased abundance of #Nitrate-reducing bacteria in UC patients.
- persistent inflammation in UC patients accumulates nonfermentable #Nitrate.
- Bifidobacterium and #Lactobacillus can utilize nonfermentable forms of #Nitrate.
[1.78] [#Gastric bypass surgery] - Roux-en-Y gastric bypass (RYGB) resulted in clear alteration in composition of gut fungal and bacterial microbiota.
- Before surgery, patients had higher levels of #Firmicutes and #Actinobacteria and lower levels of #Verrucomicrobia
- #Faecalibacterium and Bifidobacterium showed a decrease after surgery and aerotolerant #Streptococcus was increased postoperatively.
- The relative abundance of #Proteobacteria was increased after surgery.
- Changes in fungal microbiota composition included decreases in #Candida and #Saccharomyces and increases in #Pichia.
- levels of #Verrucomicrobia and #Proteobacteria increased after the surgery procedure
- Bifidobacteriaceae abundance decreased, whereas Streptococcaceae and Enterobacteriaceae increased after surgery.
- RYGB led to increased #Firmicutes and #Actinobacteria phyla but decreased #Bacteroidetes phylum
[#Attention Deficit Hyperactivity Disorder] - Bifidobacterium produces gamma-aminobutyric acid (#GABA), which is the primary repressive neurotransmitter in the human cerebral cortex.
- #GABA levels in #Children with ADHD is reportedly low and negatively correlated with impulsive behavior
[1.81] [#Fecal Microbiota Transplantation, #Immune checkpoint inhibitor] - Comparison of pre- and post-FMT stool samples in Immune checkpoint inhibitors patients with complete responses showed significant increases in alpha diversity and increases in the abundances of #Collinsella and Bifidobacterium, which were depleted in FMT responders before FMT.
[1.82] [#Alzheimer’s disease] - co-housing wild-type mice with AD transgenic mice or giving them AD transgenic mice feces caused AD-associated gut microbiota dysbiosis, #Tau phosphorylation, and #Cognitive impairment.
- Gavage with #Lactobacillus and Bifidobacterium restored these changes.
[1.84] [#Akkermansia muciniphila] [#Lipopolysaccharide] - the pro-inflammatory nature of a potential pathobiont such as A. muciniphila is determined by the presence or absence of other beneficial bacteria such as Bifidobacterium spp., modulation of LPS biosynthesis, and immunostimulatory capacity
- Only Bifidobacterium and #Akkermansia, have evolved the capacity to utilize mucin as a nutrient source
[#Bifidobacterium adolescentis] - most Bifidobacterium spp. metabolize plant carbohydrates as a main food source, but some, including B. adolescentis, can also utilize mucin as a food source
[1.86] [#Non alcoholic steatohepatitis] [#Probiotic] - Probiotics, such as Bifidobacterium and #Lactobacillus strains, have been shown to reduce oxidative and inflammatory liver damage while also decreasing hepatic triglycerides (TG) and hepatic steatosis.
[1.87] [#Keto diet] - Ketogenic diet exposure significantly altered gut microbial community structure, which was characterized by notably decreased Bifidobacterium.
[1.88] - T-cells stimulated with #Staphylococci become Th1-type cells; however, this differentiation is mitigated in Bifidobacterium-stimulated T-cells.
- prestimulation of T-cells with Bifidobacterium suppresses the activation of #Staphylococcus-specific T-helper cells in a cell-cell dependent manner by inducing FoxP3+CD4+ T-cells, increasing #IL-10 and galectin-1 secretion and showing a CTLA-4-dependent inhibitory capacity.
- Bifidobacterium dampens Th responses of severely ill #Covid-19 patients likely contributing to resolution of harmful overreactions of the immune system.