Microbiome & Chronic Diseases

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Akkermansiaceae ⇒ Akkermansia {10000161}

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Enzyme:[  ]
Mucin-degrading, Anti-inflammatory


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Shared Reference Notes

  • [1.1
    -Increased abundance of Akkermansia and Holdemania were found to be predictive of MS. - Akkermansia showed negative associations with the bile acid components taurocholate, bile acid glycocholate and fatty acid anions 3-hydroxyoctanoate and caproate. - The identification of bile acids associated with a number of our taxa is consistent with several studies showing an integral role of the gut bile acid pool as a modulator of host immune response and inflammation
  • [1.2
    - Akkermansia spp can reduce inflammation by a number of different mechanisms such as reducing plasma level of lipopolysaccharide (LPS)-binding protein (LBP), reducing the expression of inflammatory genes, and reducing the production of pro-inflammatory cytokines such as IL-17, IL-23, IL-8, TNF-α as well as increasing the production of anti-inflammatory cytokines such as IL-10 and IL-12. - While low levels of Akkermansia were found in obesity and type-2 diabetes mouse models, exogenous administration of Akkermansia increased the control of gut inflammation and permeability by regulating tight-junction-related proteins, and thickening the intestinal mucous layer.
  • [#High-fat diet] - The population of Akkermansia in the gut is negatively modulated by the fat content of the consumed diet.
  • [#Diabetes Type 2] - The commonly used diabetes treatment #Metformin increase Akkermansia spp. abundance, and to significantly improve glucose metabolism in high-fat diet fed mice while also increasing the number of mucin-producing goblet cells.
  • [1.3] [#Obesity] [#Human breast milk
    - Infants fed with breast milk rich in #Betaine showed reduced growth rates after birth. - Experiments in mice showed that giving #Betaine to female mice improved blood sugar metabolism and lowered fat tissue in breastfeeding offspring. - When breast-fed with milk rich in #Betaine, both mouse pups and human infants had higher amounts of Akkermansia bacteria in their guts. - Low levels of maternal #Betaine during pregnancy are linked to increased infant weight at birth. - Maternal #Betaine supplementation resulted in lower fetal weight in a mouse study.
  • [1.4] [#Diabetes Type 2
    - In a mouse model oral administration of Akkermansia activated toll-like receptor 2, increased the expression of epithelial tight-junction proteins, and reversed high-fat diet-induced insulin resistance - Akkermansia was the only genus that was underrepresented in patients with elevated HbA1c
  • [1.5] [#Exercise training
    - Exercise increases > increase α-diversity and microbial metabolites such as SCFAs. - Exercise > typically reveal increases in commensal taxa such as #Bifidobacterium, #Lactobacilli, and Akkermansia
  • [#High-protein diet] - High-protein group > decreased abundance of #Veillonellaceae, Akkermansia, uncultured #Eggerthellaceae, and #Ruminococcaceae UCG-010
  • [1.6] [#Lachnospiraceae
    - 4 weeks of #Grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing #Verrucomicrobia at the phylum level, and a significant increase in Akkermansia and increase in #Flavonifractor and Lachnospiraceae_UCG-010 > decrease in #Bifidobacterium and #Dialister at the genus level.
  • [1.7] [#Alzheimer’s disease
    - Decrease in #Bacteroidetes and #Alloprevotella and increase in #Proteobacteria, #Verrucomicrobia, Akkermansia, and #Desulfovibrio > improve short-term memory ability and cognitive level of AD mice
  • [#Parkinson’s Disease] [#Bifidobacterium adolescentis] - PD patients, showing an increase in Akkermansia, Bifidobacterium, and #Lactobacillus and a decrease in #Prevotella
  • [1.8] [#Ruminococcaceae] [#High-fat diet
    - HFD > decrease relative abundance of #Verrucomicrobia, Akkermansia , Ruminococcaceae_UCG-014 and #Bifidobacteriaceae
  • [#Bifidobacteriaceae, #Ruminococcaceae] [#Moderate Treadmill Exercise] - Exercise > increase the relative abundance of #Verrucomicrobia, Akkermansia and Ruminococcaceae_UCG-014
  • [1.9] [#Parkinson’s Disease
    - increased relative abundance of the Akkermansia genera over time among individuals with PD across multiple geographic locations (Finland, Germany, Japan, Russia, and United States) - an increase in the relative abundance of genus Akkermansia, a genus of mucin-metabolizing bacteria that are commonly elevated among individuals with PD, in individuals with RBD (REM sleep behavior disorder)
  • [#Parkinson’s Disease] - Mucin degrading genus Akkermansia of the phylum #Verrucomicrobia has been widely reported to be significantly abundant in PD by most studies. Akkermansia and Christensenellaceae may symbiotically play a role in PD pathology and progression
  • [#Parkinson’s Disease] - Intestinal mucus layer is rich in protein mucin. Akkermansia utilises mucin as a nutritional source and degrades it into SCFA #Acetate, which acts as a substrate for other beneficial bacteria to produce butyrate, an energy source for the intestinal epithelial cells. - Akkermansia is a symbiont that degrades mucin and encourages cells to produce more mucin. - A compensatory effect of richness in Akkermansia is possibly due to depleting cellulose-degrading bacteria in the PD gut
  • [1.11
    - Decreases in SCFA-producing bacteria, specifically belonging to Akkermansia and #Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical #Sleep Deprivation and 3-day continuous #Sleep Deprivation. - Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption. - #Sleep Deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of #Lactobacillus plantarum.
  • - patients with psoriasis report a relative reduction in intestinal abundance of Akkermansia, #Ruminococcus, or #Faecalibacterium genera, which are all comprised of mucin-degrading SCFA-producing commensals.
  • [1.12] [#Inflamatory bowel disease
    - studies have demonstrated striking differences between luminal and mucosal samples within the colon itself, specifically regarding mucosa-associated bacteria such as #Bifidobacterium, #Lactobacillus, and Akkermansia. - the microbial community composition is different between ileal luminal samples from colonic and fecal samples, as well along the length of the colon itself.
  • [1.13] [#Poly-unsaturated fatty acid] [#High satureted fat diet
    Presence of Akkermansia showed positive correlation with intake of saturated fats and negative correlation with respect to polyunsaturated fatty acids (PUFA) present in overall diet.
  • [1.14] [#Multiple Sclerosis] [#Blautia wexlerae, #Erysipelotrichaceae CCMM
    - In both progressive MS and RRMS > increased #Clostridium bolteae, #Ruthenibacterium lactatiformans, and Akkermansia and decreased #Blautia wexlerae, #Dorea formicigenerans, and #Erysipelotrichaceae CCMM. - Unique to progressive MS, has elevated Enterobacteriaceae and Clostridium g24 FCEY and decreased #Blautia and #Agathobaculum.
  • [1.15] [#Cancer, #Neutropenia] [#Chemotherapy treatment
    - Transferring gut microbiota from patients with neutropenic #Fever to irradiated mice promoted the development of subsequent #Fever. - An excess of mucin-degrading Akkermansia bacteria found in the transferred microbiomes of febrile patients, as well as in nontransplanted but irradiated or chemotherapy-treated mice that reduced their food intake, resulted in a compromised intestinal barrier in mice that could be circumvented by administration of propionate.
  • [1.16] [#Parkinson’s Disease
    - PD > increased relative abundance of family Enterobacteriaceae, genera Akkermansia, #Lactobacillus, #Bifidobacterium. - PD > decreased relative abundance of family #Lachnospiraceae, #Faecalibacterium
  • [1.17] [#Epigallocatechingallat, #Short Chain Fatty Acid
    - ECGC contribute significantly also to increase the number of SCFAs-producing bacteria, especially Akkermansia, enhancing the colon barrier integrity and general anti-inflammatory effects.
  • [1.18
    - #Breast cancer intramural Microbial biomarkers #Acinetobacter, #Citrobacter, #Enterobacter, #Staphylococcus, #Paracoccus and Akkermansia were differentially abundant in breast tumors from #Black women compared with those from white women.
  • [1.19] [#Short Chain Fatty Acid
    - in #Centenarians, longevity is positively associated with an abundance of short-chain fatty acid (SCFA) producers, such as #Clostridium cluster XIVa, #Ruminococcaceae, Akkermansia, and #Christensenellaceae
  • - good immunological and metabolic health-related bacteria, such as Akkermansia, #Christensenellaceae, and #Lactobacillus, were higher in #Centenarians than in other groups
  • - #Coriobacteriaceae and Akkermansia correlated negatively with senescence-associated secretory phenotype (SASP).
  • [#Clostridium clusters XIVa] - elevated levels of #Anaerotruncus spp., Clostridium XIVa, and #Lachnospiraceae in #Parkinson’s Disease patients were associated with dyskinesia symptoms in #Parkinson’s Disease patients, while elevations in Akkermansia were associated with non-motor impairments in #Parkinson’s Disease patients
  • [1.21] [#Inflamatory bowel disease] [#Akkermansia muciniphila] [#Antibiotic Therapy
    - Conditions like inflammatory bowel disease (IBD), #Salmonella typhimurium infection or post-antibiotic reconstitution may not benefit from Akkermansia supplementation. - using Akkermansia in patients with endocrine and gynecological disorders—such as #Polycystic ovary syndrome (PCOS) or #Endometriosis—that have a higher risk of developing IBD, should be critically evaluated. - the gut microbiota of patients suffering from #Parkinson’s Disease or #Multiple Sclerosis exhibits a characteristic signature of Akkermansia municiphila abundance.

References Notes

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Common References