Microbiome & Chronic Diseases

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Akkermansia ⇒ Akkermansiaceae {10000161}

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Enzyme:[  ]
Mucin-degrading, Anti-inflammatory


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References Notes

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Shared Reference Notes

  • [1.48
    -Increased abundance of Akkermansia and Holdemania were found to be predictive of MS.
    - Akkermansia showed negative associations with the bile acid components taurocholate, bile acid glycocholate and fatty acid anions 3-hydroxyoctanoate and caproate.
    - The identification of bile acids associated with a number of our taxa is consistent with several studies showing an integral role of the gut bile acid pool as a modulator of host immune response and inflammation
  • [1.49
    - Akkermansia spp can reduce inflammation by a number of different mechanisms such as reducing plasma level of lipopolysaccharide (LPS)-binding protein (LBP), reducing the expression of inflammatory genes, and reducing the production of pro-inflammatory cytokines such as IL-17, IL-23, IL-8, TNF-α as well as increasing the production of anti-inflammatory cytokines such as IL-10 and IL-12.
    - While low levels of Akkermansia were found in obesity and type-2 diabetes mouse models, exogenous administration of Akkermansia increased the control of gut inflammation and permeability by regulating tight-junction-related proteins, and thickening the intestinal mucous layer.
  • - The commonly used diabetes treatment Metformin increase Akkermansia spp. abundance, and to significantly improve glucose metabolism in high-fat diet fed mice while also increasing the number of mucin-producing goblet cells.
  • - The population of Akkermansia in the gut is negatively modulated by the fat content of the consumed diet.
  • [1.45
    - Infants fed with breast milk rich in betaine showed reduced growth rates after birth.
    - Experiments in mice showed that giving betaine to female mice improved blood sugar metabolism and lowered fat tissue in breastfeeding offspring.
    - When breast-fed with milk rich in betaine, both mouse pups and human infants had higher amounts of Akkermansia bacteria in their guts.
    - Low levels of maternal betaine during pregnancy are linked to increased infant weight at birth.
    - Maternal betaine supplementation resulted in lower fetal weight in a mouse study.
  • [1.50
    - In a mouse model oral administration of Akkermansia activated toll-like receptor 2, increased the expression of epithelial tight-junction proteins, and reversed high-fat diet-induced insulin resistance
    - Akkermansia was the only genus that was underrepresented in patients with elevated HbA1c
  • [1.51
    - Exercise increases > increase α-diversity and microbial metabolites such as SCFAs.
    - Exercise > typically reveal increases in commensal taxa such as Bifidobacterium, Lactobacilli, and Akkermansia
  • - High-protein group > decreased abundance of Veillonellaceae, Akkermansia, uncultured Eggerthellaceae, and Ruminococcaceae UCG-010
  • [1.52
    - 4 weeks of grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing Verrucomicrobia at the phylum level, and a significant increase in Akkermansia and increase in Flavonifractor and Lachnospiraceae_UCG-010 > decrease in Bifidobacterium and Dialister at the genus level.
  • [1.53
    - Decrease in Bacteroidetes and Alloprevotella and increase in Proteobacteria, Verrucomicrobia, Akkermansia, and Desulfovibrio > improve short-term memory ability and cognitive level of AD mice
  • - PD patients, showing an increase in Akkermansia, Bifidobacterium, and Lactobacillus and a decrease in Prevotella
  • [1.54
    - Exercise > increase the relative abundance of Verrucomicrobia, Akkermansia and Ruminococcaceae_UCG-014
  • - HFD > decrease relative abundance of Verrucomicrobia, Akkermansia , Ruminococcaceae_UCG-014 and Bifidobacteriaceae
  • [1.55
    - increased relative abundance of the Akkermansia genera over time among individuals with PD across multiple geographic locations (Finland, Germany, Japan, Russia, and United States)
    - an increase in the relative abundance of genus Akkermansia, a genus of mucin-metabolizing bacteria that are commonly elevated among individuals with PD, in individuals with RBD (REM sleep behavior disorder)
  • [1.18
    - Mucin degrading genus Akkermansia of the phylum Verrucomicrobia has been widely reported to be significantly abundant in PD by most studies. Akkermansia and Christensenellaceae may symbiotically play a role in PD pathology and progression
  • - Intestinal mucus layer is rich in protein mucin. Akkermansia utilises mucin as a nutritional source and degrades it into SCFA acetate, which acts as a substrate for other beneficial bacteria to produce butyrate, an energy source for the intestinal epithelial cells.
    - Akkermansia is a symbiont that degrades mucin and encourages cells to produce more mucin.
    - A compensatory effect of richness in Akkermansia is possibly due to depleting cellulose-degrading bacteria in the PD gut
  • [1.47
    - patients with psoriasis report a relative reduction in intestinal abundance of Akkermansia, Ruminococcus, or Faecalibacterium genera, which are all comprised of mucin-degrading SCFA-producing commensals.
  • - Decreases in SCFA-producing bacteria, specifically belonging to Akkermansia and Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical sleep deprivation and 3-day continuous sleep deprivation.
    - Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption.
    - sleep deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of Lactobacillus plantarum.
  • [1.56
    - studies have demonstrated striking differences between luminal and mucosal samples within the colon itself, specifically regarding mucosa-associated bacteria such as Bifidobacterium, Lactobacillus, and Akkermansia.
    - the microbial community composition is different between ileal luminal samples from colonic and fecal samples, as well along the length of the colon itself.

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