Akkermansia ⇒ Akkermansiaceae {10000161}
Organism: | Akkermansia |
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Parent: |
Initialisation date: | 2019-05-05 |
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Rank: | Genus |
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Domain: | Bacteria |
Zone: | [ ] |
Enzyme: | [ ] |
Function: | Mucin-degrading, Anti-inflammatory |
Notes:
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References Notes
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Shared Reference Notes
- [1.48]
-Increased abundance of Akkermansia and Holdemania were found to be predictive of MS.
- Akkermansia showed negative associations with the bile acid components taurocholate, bile acid glycocholate and fatty acid anions 3-hydroxyoctanoate and caproate.
- The identification of bile acids associated with a number of our taxa is consistent with several studies showing an integral role of the gut bile acid pool as a modulator of host immune response and inflammation - [1.49]
- Akkermansia spp can reduce inflammation by a number of different mechanisms such as reducing plasma level of lipopolysaccharide (LPS)-binding protein (LBP), reducing the expression of inflammatory genes, and reducing the production of pro-inflammatory cytokines such as IL-17, IL-23, IL-8, TNF-α as well as increasing the production of anti-inflammatory cytokines such as IL-10 and IL-12.
- While low levels of Akkermansia were found in obesity and type-2 diabetes mouse models, exogenous administration of Akkermansia increased the control of gut inflammation and permeability by regulating tight-junction-related proteins, and thickening the intestinal mucous layer. - - The commonly used diabetes treatment Metformin increase Akkermansia spp. abundance, and to significantly improve glucose metabolism in high-fat diet fed mice while also increasing the number of mucin-producing goblet cells.
- - The population of Akkermansia in the gut is negatively modulated by the fat content of the consumed diet.
- [1.45]
- Infants fed with breast milk rich in betaine showed reduced growth rates after birth.
- Experiments in mice showed that giving betaine to female mice improved blood sugar metabolism and lowered fat tissue in breastfeeding offspring.
- When breast-fed with milk rich in betaine, both mouse pups and human infants had higher amounts of Akkermansia bacteria in their guts.
- Low levels of maternal betaine during pregnancy are linked to increased infant weight at birth.
- Maternal betaine supplementation resulted in lower fetal weight in a mouse study. - [1.50]
- In a mouse model oral administration of Akkermansia activated toll-like receptor 2, increased the expression of epithelial tight-junction proteins, and reversed high-fat diet-induced insulin resistance
- Akkermansia was the only genus that was underrepresented in patients with elevated HbA1c - [1.51]
- Exercise increases > increase α-diversity and microbial metabolites such as SCFAs.
- Exercise > typically reveal increases in commensal taxa such as Bifidobacterium, Lactobacilli, and Akkermansia - - High-protein group > decreased abundance of Veillonellaceae, Akkermansia, uncultured Eggerthellaceae, and Ruminococcaceae UCG-010
- [1.52]
- 4 weeks of grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing Verrucomicrobia at the phylum level, and a significant increase in Akkermansia and increase in Flavonifractor and Lachnospiraceae_UCG-010 > decrease in Bifidobacterium and Dialister at the genus level. - [1.53]
- Decrease in Bacteroidetes and Alloprevotella and increase in Proteobacteria, Verrucomicrobia, Akkermansia, and Desulfovibrio > improve short-term memory ability and cognitive level of AD mice - - PD patients, showing an increase in Akkermansia, Bifidobacterium, and Lactobacillus and a decrease in Prevotella
- [1.54]
- Exercise > increase the relative abundance of Verrucomicrobia, Akkermansia and Ruminococcaceae_UCG-014 - - HFD > decrease relative abundance of Verrucomicrobia, Akkermansia , Ruminococcaceae_UCG-014 and Bifidobacteriaceae
- [1.55]
- increased relative abundance of the Akkermansia genera over time among individuals with PD across multiple geographic locations (Finland, Germany, Japan, Russia, and United States)
- an increase in the relative abundance of genus Akkermansia, a genus of mucin-metabolizing bacteria that are commonly elevated among individuals with PD, in individuals with RBD (REM sleep behavior disorder) - [1.18]
- Mucin degrading genus Akkermansia of the phylum Verrucomicrobia has been widely reported to be significantly abundant in PD by most studies. Akkermansia and Christensenellaceae may symbiotically play a role in PD pathology and progression - - Intestinal mucus layer is rich in protein mucin. Akkermansia utilises mucin as a nutritional source and degrades it into SCFA acetate, which acts as a substrate for other beneficial bacteria to produce butyrate, an energy source for the intestinal epithelial cells.
- Akkermansia is a symbiont that degrades mucin and encourages cells to produce more mucin.
- A compensatory effect of richness in Akkermansia is possibly due to depleting cellulose-degrading bacteria in the PD gut - [1.47]
- patients with psoriasis report a relative reduction in intestinal abundance of Akkermansia, Ruminococcus, or Faecalibacterium genera, which are all comprised of mucin-degrading SCFA-producing commensals. - - Decreases in SCFA-producing bacteria, specifically belonging to Akkermansia and Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical sleep deprivation and 3-day continuous sleep deprivation.
- Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption.
- sleep deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of Lactobacillus plantarum. - [1.56]
- studies have demonstrated striking differences between luminal and mucosal samples within the colon itself, specifically regarding mucosa-associated bacteria such as Bifidobacterium, Lactobacillus, and Akkermansia.
- the microbial community composition is different between ileal luminal samples from colonic and fecal samples, as well along the length of the colon itself.