Microbiome & Chronic Diseases

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Ruminococcaceae ⇒ Clostridiales {10000223}

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Zone:[  ]
Enzyme:[  ]
Mucin-degrading, Anti-cancer


- The second mucin-degrading enterotype is rich in Ruminococcus and Akkermansia, both able to degrade mucins. (1)

Shared Notes

  • [1.64
    -The family Ruminococcaceae has been consistently reported as less abundant in NAFLD
  • [1.65
    - High-protein group > decreased abundance of Veillonellaceae, Akkermansia, uncultured Eggerthellaceae, and Ruminococcaceae UCG-010
  • [1.66
    - Oral administration of castalagin > enriched for bacteria associated with efficient immunotherapeutic responses (Ruminococcaceae and Alistipes) and improved the CD8+/Foxp3+CD4+ ratio within the tumor microenvironment.
  • [1.67
    - Exercise > increase the relative abundance of Verrucomicrobia, Akkermansia and Ruminococcaceae_UCG-014
  • - HFD > decrease relative abundance of Verrucomicrobia, Akkermansia , Ruminococcaceae_UCG-014 and Bifidobacteriaceae
  • [1.45
    - A drastic disappearance of obligate anaerobic gut commensals (Blautia, Prevotella, Faecalibacterium, Lachnospiraceae, Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as short chain fatty acid (SCFAs)
  • [1.41
    - bacteria with capacity of butyrate production, Lachnospiraceae and Ruminococcaceae, were depleted in individuals at a high risk of stroke. Fecal butyrate concentrations also were low in these people
  • - patients with HF have a decrease in butyrate-producing bacteria, especially, Lachnospiracea and Ruminococcacea families.
    - reduction of the butyrate-producing Eubacterium Halli and Lachnospiracea is correlated with increased inflammation, severity of disease, heart damage and mortality
  • [1.63
    - Prevotellaceae (Prevotella), Ruminococcaceae (Faecalibacterium), Lachnospiraceae (Blautia, Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
  • [1.68
    - Ruminococcaceae (order Clostridiales) that are prominent producers of butyrate, decreased in relative abundance with a high-fat diet.
    - This decrease is particularly significant because Ruminococcaceae, making up ≈20% of gut bacteria in chow-fed OSA rats, decreased to ≈10% in high-fat OSA rats . Members of the order Clostridiales, other than Ruminococcaceae, also significantly decreased with high-fat diet.

Common References