Lachnospiraceae ⇒ Roseburia {10000139}

References Notes

Shared Reference Notes

• [1.103] 
  - Roseburia, was found to be reduced in IBD. - It had the highest correlations occurring in a number of bile acids (e.g., taurocholate, taurochenodeoxycholate, glycocholate), in addition to several triacylglycerols (TAGs) and fatty acids. - Specifically, the short chain fatty acid (SCFA) butyrate was found to be positively associated with Roseburia abundance, consistent with known butyrate production in the Roseburia genus. - Roseburia has a known anti-inflammatory role in the intestine and it’s positive association with butyrate is consistent with a deficiency in this genus being highly predictive of IBD.
• [1.104] [#Carbohydrate diet] 
  - Other butyrate producing microbes, e.g. Roseburia spp., fare better when they are delivered #Polysaccharide growth substrates in the diet
• [1.105] [#Saturated fatty acids (SFAs)] 
  - SFAs were positively associated with Roseburia, a biomarker for the lean group.
• [1.106] [#Therapeutic drugs] 
  - Statins combined with aspirin > synergistic reduction in serum atherogenic lipoproteins. - Diuretic agents combined with beta-blockers > enrichment of intestinal Roseburia
• [1.100] 
  - #Protein powder consumption > decrease in #Lachnospiraceae, Roseburia, #Blautia, Synergistales, #Coprococcus, #Lactobacillales, Bacilli, #Bifidobacterium longum and #Firmicutes. - #Protein powder consumption > higher abundance of #Bacteroidetes.
• [1.76] [#Psychogenic erectile dysfunction] 
  - Erectile dysfunction > no #Alloprevotella . - Erectile dysfunction > increased #Streptococci and #Subdoligranulum - Erectile dysfunction > decreased #Prevotella sp.9, #Blautia, #Lachnospiraceae NK4A136 groups and Roseburia.
• [1.67] [#Parkinson’s Disease] 
  - #Prevotellaceae (Prevotella), #Ruminococcaceae (#Faecalibacterium), #Lachnospiraceae (#Blautia, Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
• [1.92] [#Omega 3] [#Omega 3 Supplementation] 
  - Roseburia may also be enhanced by omega-3 fatty acids in nuts, as its relative abundance was increased in humans as a result of both a walnut-supplemented diet and a diet with the same fatty-acid composition without walnuts
• [1.68] [#Parkinson’s Disease] 
  - lower fecal #Butyrate and reduced counts of genera Roseburia, #Romboutsia, and #Prevotella are related to depressive symptoms in PD patients. - Decreased levels of bacterially produced #Butyrate are related to epigenetic changes in leucocytes and neurons from PD patients and to the severity of their depressive symptoms.
• [1.107] [#Asthma] [#Children] 
  - low α-diversity and relative abundance of particular gut-commensal bacteria genera (#Bifidobacterium, #Faecalibacterium, #Ruminococcus, and Roseburia) are associated with childhood respiratory diseases.
• [1.108] [#Vegetarian diet] 
  - Dominant species in vegetarians are #Ruminococcus, Roseburia, and #Eubacterium.
• [1.109] [#Infants, #Mother-infant] 
  - Maternal gut strains transmitted after the first 3 months of life included members of the genera #Eubacterium, Roseburia, and #Blautia.
• [1.70] [#Parkinson’s Disease] [#Short Chain Fatty Acid] 
  - PD > a dramatic ~2.5-fold reduction for several SCFA producing species, and as much as 5 to 7.5 fold reduction in Roseburia species.
• [1.102] [#Inflamatory bowel disease] [#Short Chain Fatty Acid] 
  The first signs of aggravation of IBD are : - a loss of the main anti-inflammatory Short-Chain Fatty Acids (SCFAs) Roseburia, #Eubacterium, #Subdoligranumum, #Ruminococcus - an increase in pro-inflammatory pathogens Proteus, Finegoldia - an increase of other minor SCFA producers such as #Ezakiella, #Anaerococcus, #Megasphaera, #Anaeroglobus, #Fenollaria. - Further aggravation of clinical signs is significantly linked to the subsequent loss of these minor SCFAs species and to an increase in other proinflammatory Proteobacteria such as Klebsiella, Pseudomonas, Salmonella, Acinetobacter, Hafnia and proinflammatory Firmicutes such as Staphylococcus, Enterococcus, Streptococcus.
• [1.110] [#Multiple Sclerosis] [#Lipocalin-2] 
  - bacteria thought to be beneficial for inflammatory bowel disease (IBD) such as #Anaerobutyricum, #Blautia, and Roseburia, were reduced in fecal Lcn-2-high MS patients.
• [1.111] [#Crohn’s disease] [#Clostridium cluster IV] 
  - Roseburia, #Gemmiger, #Coprococcus, #Ruminococcus 2, #Butyricicoccus, #Dorea, #Fusicatenibacter, #Anaerostipes, Clostridium IV were enriched in the healthy controls. - #Blautia, Clostridium IV, #Coprococcus, #Dorea, #Fusicatenibacter continued to significantly decrease in early and advanced CD patients, and Escherichia/Shigella and Proteus continued to significantly increase. - negative correlation between #Dorea, #Butyricicoccus, Roseburia and gland reduce, Roseburia and FC, #Butyricicoccus and goblet cells decreased, Parabacterodies and sex, Clostridium IV and CRP, #Dorea and ESR . - positive correlation between Escherichia/Shigella and CRP, #Ruminococcus 2 and clinical symptoms.