Disease ⇒ Helicobacter pylori infection {40000300}
| Type: | Disease |
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| Parent: | [ ] |
| Definition: | Helicobacter pylori infection |
| Initialisation date: | [ ] |
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| Other Terms: | [ ] |
| MedDra ID: | 10054263 |
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| MedDra Level: | pt |
| ICD: | [ ] |
| Category: | [ ] |
| Zone: | [ ] |
| Mechanism: | [ ] |
Notes:
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Shared Reference Notes
- [1.1] [#Alzheimer’s disease]
- 11% increase in the risk of AD associated with exposure to CAHPI (clinically apparent #Helicobacter pylori infection) among subjects aged at least 50 years. - The increase in the risk of AD reached a peak of 24% roughly a decade after the onset of CAHPI > statistical significance roughly 8 years following CAHPI onset, peaked 2 years later, and decreased afterwards. - - Helicobacter pylori infection > structural damage in gastric mucosa caused by chronic HP infection could affect the absorption of #Vitamin B12 and #Iron, a deficit of which is associated with #Dementia.
- [#Helicobacter pylori] - HP can access the brain via the oral-nasal-olfactory axis or by infected circulating monocytes through a disrupted blood-brain-barrier > potentially leading to neuroinflammation, neuronal damage, and neurodegeneration.
References Notes
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