Microbiome & Chronic Diseases

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Prevotella copri ⇒ Prevotella {10000121}

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Prevotella copri


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Shared Notes

  • [1.30
    - Prevotella copri aids in metabolizing fibers in healthy individuals and protects against bacterial invasion in high fiber, chow-fed mice, is yet associates with insulin resistance in prediabetic obese individuals and precipitates glucoregulatory impairments in diet-induced obese (DIO) mice.
  • [1.31
    - The protective association between adherence to the Mediterranean diet and cardiometabolic disease risk is significantly stronger among participants with decreased abundance of Prevotella copri.
  • [1.32
    - High fiber diet > Prevotella copri > improve glucose and insulin tolerance.
  • [1.33
    - P. copri appears to mediate metabolic dysfunction in Western diet-fed NHPs
  • [1.7
    - Prevotella copri > thrives in a pro-inflammatory environment.
    - The superoxide reductase and phosphoadenosine phosphosulphate reductase encoded by Prevotella copri > may favor the development of inflammation.
    - Colonization with Prevotella copri > enhances body weight loss and exacerbates epithelial inflammation in colitis mouse model.
  • [1.34
    - Non-industrialized countries > increased Prevotella copri, Faecalibacterium prausnitzii and Prevotella stercorea in infants.

  • - Infants > after weaning > P. copri > rapidly dominant independently of other species.
  • - Whole grains contain unique hemicellulose fibers, such as xylans and β-(1 → 3,1 → 4)-glucans, in addition to cellulose, resistant starches, and oligosaccharides.
    - Whole grains > an enrichment of putative health-promoting organisms, such as Bifidobacterium and butyrate producers (Eubacterium rectale, Roseburia faecis, and Roseburia intestinalis), and enhancement of the SCFA producer Lachnospira, increased fecal acetate and total SCFAs, and reduced Enterobacteriaceae.
    - Whole grains > glucose metabolism improved due to > High Prevotella/Bacteroides ratios and Prevotella copri abundance and microbial genes encoding for complex polysaccharide degradation were elevated
  • - Germ-free mice gavaged either with Prevotella copri or “responder” human-derived microbiomes containing P. copri showed improvements in glucose tolerance when fed standard chow diets, which was mechanistically associated with increased hepatic glycogen storage.

Common References