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Microbiome & Chronic Diseases

Evidence Based Medicine
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Disease ⇒ Liver fibrosis {40000302}

Record Keys


Type:
Disease
Definition:
Liver fibrosis
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:[  ]

Meta Information


MedDra ID:
10019668
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


[  ]

Shared Reference Notes


  • [1.3
    - Intestinal HDL is not routed to the systemic circulation. Rather, in the form of HDL3, it is directly transported to the liver through the hepatic portal vein.
    - There, it sequesters bacterial lipopolysaccharide from the gut that can trigger inflammation and liver damage.
    - In various models of liver injury, loss of enteric HDL exacerbated pathology.
    - By contrast, drugs elevating intestinal HDL improved disease outcomes.