Disease ⇒ Liver fibrosis {40000302}
| Type: | Disease |
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| Definition: | Liver fibrosis |
| Parent: | [ ] |
| Initialisation date: | [ ] |
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| Other Terms: | [ ] |
| MedDra ID: | 10019668 |
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| MedDra Level: | pt |
| ICD: | [ ] |
| Category: | [ ] |
| Zone: | [ ] |
| Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.3]
- Intestinal HDL is not routed to the systemic circulation. Rather, in the form of HDL3, it is directly transported to the liver through the hepatic portal vein.
- There, it sequesters bacterial lipopolysaccharide from the gut that can trigger inflammation and liver damage.
- In various models of liver injury, loss of enteric HDL exacerbated pathology.
- By contrast, drugs elevating intestinal HDL improved disease outcomes.