Microbiome & Chronic Diseases

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Prevotella ⇒ Prevotellaceae {10000253}

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- Prevotella contains enzymes that are important in mucin degradation, which may disrupt the colonic mucus barrier and increase intestinal permeability

References Notes

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Shared Reference Notes

  • [1.193
    - There is a correlation between higher gut microbiota diversity and higher vegetable intake, but only in participants who harbored an overrepresentation of Prevotella in their gut microbiota
  • [1.194
    - Recent exposure to antibiotics is the best predictor of decreased Prevotella.
  • - There is a clear association between decreased normalised abundance of Prevotella in faecal samples collected at 12 months of age and increased behavioural problems at 2 years.
  • [1.195
    - Lactobacillus given to letrozole-treated (induces PCOS) rats reduced androgen levels, improved estrous cyclicity, normalized ovarian morphology, as well as increased Lactobacillus and Clostridium species and decreased Prevotella.
  • [1.196
    - Carbohydrate (fiber) consumption > increased Prevotella
  • - Prevotella are more common in non-Westernized populations consuming a plant-rich diet or in Western populations with high adherence to a Mediterranean or vegetarian diet
  • [1.197
    - Prevotella grows best on carbohydrates.
  • [1.198
    - Prevotella in saliva is at higher relative abundance compared to healthy controls.
  • [1.51
    - 9,10-dichloro-octadecanoic acid (stearic acid) > positive association > microflora including Klebsiella, Prevotella, and Enterbacter > all overrepresented in HTN.
    - In HTN > microbial richness and diversity > decreased with Prevotella-dominated gut enterotype.
    - Faecalibacterium, Oscillibacter, Roseburia, Bifidobacterium, Coprococcus, and Butyrivibrio > declined in pHTN and HTN patients.
    - The enterotype dominated by Prevotella > increased in pHTN and HTN populations.
    - Stearic acid, an important metabolite in HTN, is positively linked to Prevotella.
    - Prevotella > triggering the inflammatory response > HTN.
  • [1.199
    - Decreased Prevotella > faster PD progression
  • [1.200
    - PD patients, showing an increase in Akkermansia, Bifidobacterium, and Lactobacillus and a decrease in Prevotella
  • [1.174
    - Erectile dysfunction > no Alloprevotella .
    - Erectile dysfunction > increased streptococci and Subdoligranulum
    - Erectile dysfunction > decreased Prevotella sp.9, Blautia, Lachnospiraceae NK4A136 groups and Roseburia.
  • [1.201
    - high protein/animal fat diets are associated with Bacteroides, whereas diets high in carbohydrates are associated with a high prevalence of Prevotella
  • [1.61
    - abundance of Bacillales Family XI incertae sedis and Prevotella families were associated with lower risk of colonization by MDRO, infection and death
  • [1.41
    - A drastic disappearance of obligate anaerobic gut commensals (Blautia, Prevotella, Faecalibacterium, Lachnospiraceae, Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as short chain fatty acid (SCFAs)
  • [1.202
    - RS consumption was associated with an increased abundance of either Bacteroides or Prevotella transcripts.
  • [1.109
    - The gut microbial communities of the ALS patients were more diverse and were deficient in Prevotella spp. compared with those of their spouses.
    - Predictive analysis of microbial enzymes revealed that ALS patients had decreased activity in several metabolic pathways, including carbon metabolism, butyrate metabolism, and systems involving histidine kinase and response regulators.
  • [1.71
    - Certain bacterial species of the genus Corynebacterium, Porphyromonas, and Prevotella have been noted to be significantly abundant in PD and associated with SCNA genes.
    - An overabundance of the unusually low Corynebacterium and endotoxins of the Porphyromonas and Prevotella can trigger the PD pathology in the gut.
  • [1.143
    - that abundance of Prevotella spp. may play a protective role against gallstones formation by regulation of the BAs composition, reducing metabolic endotoxaemia and protection of the mucosal gut barrier.
  • - Mucosal inflammation mediated by Prevotella spp. could promote systemic dissemination of various pro-inflammatory mediators, as well as bacteria and bacterial products, which in turn may trigger systemic diseases.
  • [1.63
    - Harboring high levels of Prevotella at baseline resulted in increased weight loss in individuals with excess body weight who consumed whole grain-rich diets
  • [1.169
    - lower fecal butyrate and reduced counts of genera Roseburia, Romboutsia, and Prevotella are related to depressive symptoms in PD patients.
    - Decreased levels of bacterially produced butyrate are related to epigenetic changes in leucocytes and neurons from PD patients and to the severity of their depressive symptoms.

Common References