Microbiome & Chronic Diseases

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Prevotella ⇒ Prevotellaceae {10000253}

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- Prevotella contains enzymes that are important in mucin degradation, which may disrupt the colonic mucus barrier and increase intestinal permeability

References Notes

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Shared Reference Notes

  • [1.203
    - There is a correlation between higher gut microbiota diversity and higher vegetable intake, but only in participants who harbored an overrepresentation of Prevotella in their gut microbiota
  • [1.204] [#Antibiotic Therapy
    - Recent exposure to antibiotics is the best predictor of decreased Prevotella.
  • [#Infants] - There is a clear association between decreased normalised abundance of Prevotella in faecal samples collected at 12 months of age and increased behavioural problems at 2 years.
  • [1.205] [#Polycystic ovary syndrome
    - #Lactobacillus given to letrozole-treated (induces PCOS) rats reduced androgen levels, improved estrous cyclicity, normalized ovarian morphology, as well as increased #Lactobacillus and #Clostridium species and decreased Prevotella.
  • [1.198] [#High-fiber diet
    - Carbohydrate (fiber) consumption > increased Prevotella
  • [#Mediterranean diet] - Prevotella are more common in non-Westernized populations consuming a plant-rich diet or in Western populations with high adherence to a Mediterranean or vegetarian diet
  • [1.206] [#Carbohydrate diet
    - Prevotella grows best on carbohydrates.
  • [1.207] [#Rheumatoid Arthritis
    - Prevotella in saliva is at higher relative abundance compared to healthy controls.
  • [1.208] [#Parkinson’s Disease
    - Decreased Prevotella > faster PD progression
  • [1.53] [#Hypertension
    - 9,10-dichloro-octadecanoic acid (stearic acid) > positive association > microflora including Klebsiella, Prevotella, and Enterbacter > all overrepresented in HTN. - In HTN > microbial richness and diversity > decreased with Prevotella-dominated gut enterotype. - Faecalibacterium, Oscillibacter, Roseburia, Bifidobacterium, Coprococcus, and Butyrivibrio > declined in pHTN and HTN patients. - The enterotype dominated by Prevotella > increased in pHTN and HTN populations. - Stearic acid, an important metabolite in HTN, is positively linked to Prevotella. - Prevotella > triggering the inflammatory response > HTN.
  • [1.209] [#Parkinson’s Disease] [#Bifidobacterium adolescentis
    - PD patients, showing an increase in #Akkermansia, Bifidobacterium, and #Lactobacillus and a decrease in Prevotella
  • [1.177] [#Psychogenic erectile dysfunction
    - Erectile dysfunction > no #Alloprevotella . - Erectile dysfunction > increased #Streptococci and #Subdoligranulum - Erectile dysfunction > decreased Prevotella sp.9, #Blautia, #Lachnospiraceae NK4A136 groups and #Roseburia.
  • [1.196] [#Carbohydrate diet, #High protein / animal fat diets
    - high protein animal fat diets are associated with #Bacteroides, whereas diets high in carbohydrates are associated with a high prevalence of Prevotella
  • [1.63] [#Multidrug-Resistant Organism
    - abundance of Bacillales Family XI incertae sedis and Prevotella families were associated with lower risk of colonization by MDRO, infection and death
  • [1.42] [#Infectious diarrhea
    - A drastic disappearance of obligate anaerobic gut commensals (#Blautia, Prevotella, #Faecalibacterium, #Lachnospiraceae, #Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs)
  • [1.201] [#Resistant starch
    - RS consumption was associated with an increased abundance of either #Bacteroides or Prevotella transcripts.
  • [1.111] [#Amyotrophic lateral sclerosis
    - The gut microbial communities of the ALS patients were more diverse and were deficient in Prevotella spp. compared with those of their spouses. - Predictive analysis of microbial enzymes revealed that ALS patients had decreased activity in several metabolic pathways, including carbon metabolism, #Butyrate metabolism, and systems involving histidine kinase and response regulators.
  • [1.73] [#Parkinson’s Disease
    - Certain bacterial species of the genus #Corynebacterium, #Porphyromonas, and Prevotella have been noted to be significantly abundant in PD and associated with #SCNA genes. - An overabundance of the unusually low #Corynebacterium and endotoxins of the #Porphyromonas and Prevotella can trigger the PD pathology in the gut.
  • [1.145] [#Gallstone Disease
    - that abundance of Prevotella spp. may play a protective role against gallstones formation by regulation of the BAs composition, reducing metabolic endotoxaemia and protection of the mucosal gut barrier.
  • - Mucosal inflammation mediated by Prevotella spp. could promote systemic dissemination of various pro-inflammatory mediators, as well as bacteria and bacterial products, which in turn may trigger systemic diseases.
  • [1.65] [#Obesity] [#Whole grains
    - Harboring high levels of Prevotella at baseline resulted in increased weight loss in individuals with excess body weight who consumed whole grain-rich diets
  • [1.172] [#Parkinson’s Disease
    - lower fecal #Butyrate and reduced counts of genera #Roseburia, #Romboutsia, and Prevotella are related to depressive symptoms in PD patients. - Decreased levels of bacterially produced #Butyrate are related to epigenetic changes in leucocytes and neurons from PD patients and to the severity of their depressive symptoms.
  • [1.26] [#Covid-19
    -anti-inflammatory bacteria, including #Bifidobacteria species and #Eubacterium rectale, with lower severity, and pro-inflammatory bacteria such as Prevotella copri with higher severity.
  • [1.160] [#Irritable bowel syndrome
    - symptom severity is related to characteristic alterations of gut microbiota, including reduced diversity, reduced exhaled methane, relative reduction of #Methanobacteriales and Prevotella enterotype, and abundance of #Bacteroides enterotype. - #Bacteroides were found to be increased in patients with IBS-D and were associated with mucosal low-grade inflammation.
  • [1.210] [#Carbohydrate diet
    - carbohydrate-rich diet was consumed Prevotella-dominated enterotype

Common References