Microbiome & Chronic Diseases

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Clostridiaceae ⇒ Clostridium {10000270}

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  • [1.70] [#Polycystic ovary syndrome
    - #Lactobacillus given to letrozole-treated (induces PCOS) rats reduced androgen levels, improved estrous cyclicity, normalized ovarian morphology, as well as increased #Lactobacillus and Clostridium species and decreased #Prevotella.
  • [1.71
    - Clostridium spp. destroy tumors by secreting exotoxins that damage the membrane structures of #Cancer cells and enter cells to disrupt essential cellular functions. - The introduction of Clostridium spp. recruits CD8+ T cells, granulocytes, and macrophages to the infection area and induces the release of TNF-related apoptosis-inducing ligand (TRAIL) from neutrophils.
  • [1.72] [#Bile Acids] [#Western-style diet
    - WD consumption in conjunction with Clostridium spp. increased the secondary bile acid deoxycholic acid levels in the ileum, which in turn inhibited Paneth cell function.
  • [1.73] [#Diabetes Type 2
    - Clostridium > negative correlation with with fasting glucose and HbA1c levels > decreased insulin resistance.
  • [1.74] [#Amyotrophic lateral sclerosis
    - ALS in mice> altered bacterial community related to autoimmunity (e.g., Clostridium sp. ASF502, #Lachnospiraceae bacterium A4), inflammation (e.g., #Enterohabdus Muris,), and metabolism (e.g., #Desulfovibrio fairfieldensis) at 1- and 2-month-old SOD1G93A mice, suggesting the early microbial contribution to the pathological changes.
  • [1.75] [#Alzheimer’s disease] [#Bacillus firmus
    - B. firmus, Rikenella, Clostridium sp. Culture-27, and #Deoxyuridine, may play important roles in AD pathology.
  • [1.76
    - the intestines and colon are enriched with anaerobes including the Clostridium and #Faecalibacterium genera.
  • [1.77] [#Lipopolysaccharide] [#Antibiotic Therapy, #Condition of chronic stress
    - stressor exposed mice had significantly altered community structure of their gut microbiota, with decreased abundance of the genus #Bacteroides and increased abundance of the genus Clostridium. This was accompanied by increased circulating levels of IL-6 and monocyte chemoattractant protein 1 (MCP-1). - In a follow-up experiment, animals were fed an antibiotic cocktail in the morning and evening by oral gavage, beginning three days before the stressor and continuing to the end of the experiment. Antibiotic treatment prevented the increases in IL-6 and MCP-1. - mice receiving the stressor had elevated hepatic portal blood levels of LPS (from the gastrointestinal draining vein) and elevated mRNA expression of IL-1β, IL-6, and TNF in the hypothalamus, though no changes in circulating cytokines. Pretreatment with L. farciminis, antibiotics, and ML-7 all prevented these increases.
  • [1.68] [#Culinary herbs and spices
    - six of seven aqueous culinary spice extracts of oregano, ginger, rosemary, cinnamon, black pepper and cayenne pepper were able to promote the growth of #Bifidobacterium spp. in vitro, whereas turmeric was not. - stimulation of #Lactobacillus spp. and inhibition of certain Clostridium spp. by all seven spices. - increase in most Clostridium spp. after turmeric and curcumin intervention in a human study.
  • [1.78] [#CVD] [#Short Chain Fatty Acid] [#Probiotic, #Probiotic (Bifidobacter and Lactobacilus)
    - Short-chain fatty acids and secondary #Bile Acids can decrease #Cholesterol levels by regulating #Cholesterol metabolism. - Microbial #Bile Salt hydrolases can increase #Cholesterol disposal rates by accelerating its conversion to #Bile Acids. - Probiotics from the genera Lactobacillus and Bifidobacterium are efficient reducers of #Cholesterol levels in clinical studies. - Several candidate next-generation probiotics, including #Akkermansia muciniphila, #Bacteroides spp., Clostridium spp., #Christensenella minuta, Eubacterium spp., and #Faecalibacterium prausnitzii, have been shown to decrease #Cholesterol levels in human or animal studies.
  • [1.79
    - levels of #Faecalibacterium prausnitzii, Bacteroides–Prevotella group, #Atopobium Cluster, #Enterobacter spp. and Clostridium Cluster IV were higher in BD patients than healthy subjects along with a reduced Bifidobacteria to Enterobacteriaceae ratio,

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