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Microbiome & Chronic Diseases

Evidence Based Medicine
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Clostridiales ⇒ Clostridia {10000119}

Record Keys


Organism:
Clostridiales
Parent:

Details


Initialisation date:
2020-09-06

Links


Meta Information


Rank:
Order
Domain:
Bacteria
Zone:[  ]
Enzyme:[  ]
Function:
Enhancing CD4(+) T regulatory, Pro-inflamatory

Notes:


- Mice colonized with Clostridia bacteria had more regulatory T cells, a type of cell that dampens immune responses. The Clostridia mice also produced more of a molecule called IL-22 that strengthens the intestinal lining. (1)

References Notes


Shared Reference Notes


  • [1.3] [#Colorectal cancer
    - Clostridiales species are significantly reduced in CRC patients compared with healthy controls. - Oral application of a mix of four Clostridiales strains (CC4) in mice prevented and even successfully treated CRC as stand-alone therapy. This effect depended on intratumoral infiltration and activation of CD8+ T cells. - Single application of Roseburia intestinalis or Anaerostipes caccae is even more effective than CC4. - The CC4 mix supplementation outperformed anti-PD-1 therapy in mouse models of CRC and melanoma.
  • [1.22] [#Parkinson’s Disease
    PD patient group, the abundance of proinflammatory microbes, such as Clostridiales bacterium NK3B98 and #Ruminococcus sp AM07-15, significantly correlated with decreased fecal levels and increased plasma levels of SCFAs, especially #Propionic acid.
  • [1.20
    - GutAlive maintained extremely #Oxygen sensitive (EOS) populations that were lost in conventional stool containers, and thus viability of species such as as #Akkermansia muciniphila, #Faecalibacterium prausnitzii and a novel member of the Clostridiales order was kept.

Common References