Blautia ⇒ Blautia wexlerae {10001360}

Shared Reference Notes

• [1.1] 
  - The abundances of Blautia wexlerae were linked to high blood levels of metabolites associated with several chronic diseases.
• [1.2] [#Diabetes Type 2] [#Oral administration of Blautia wexlerae] 
  - Blautia genus, especially B. wexlerae, as a commensal bacterium that is inversely correlated with #Obesity and type 2 diabetes mellitus. - Oral administration of B. wexlerae to mice induce metabolic changes and anti-inflammatory effects that decrease both high-fat diet–induced #Obesity and diabetes. - The beneficial effects of B. wexlerae are correlated with unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and L-ornithine and carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate, with simultaneous modification of the gut bacterial composition. - S-adenosylmethionine, acetylcholine, and L-ornithine have anti-inflammatory properties and modify aspects of host metabolism, such as lipid metabolism, indicating that these compounds are potential effector metabolites for controlling #Obesity and diabetes.
• [1.3] [#Multiple Sclerosis] [#Erysipelotrichaceae CCMM] 
  - In both progressive MS and RRMS > increased #Clostridium bolteae, #Ruthenibacterium lactatiformans, and #Akkermansia and decreased #Blautia wexlerae, #Dorea formicigenerans, and #Erysipelotrichaceae CCMM. - Unique to progressive MS, has elevated Enterobacteriaceae and Clostridium g24 FCEY and decreased #Blautia and #Agathobaculum.
• [1.4] [#Parkinson’s Disease] 
  - At one end of the spectrum, #Bifidobacterium dentium was elevated by 7-fold, #Actinomyces oris by 6.5-fold, #Streptococcus mutans by 6-fold. At the other end of the spectrum, #Roseburia intestinalis was reduced by 7.5-fold, and Blautia wexlerae by 5-fold.

References Notes