Microbiome & Chronic Diseases

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Disease ⇒ Allergy {40000209}

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Shared Reference Notes

  • [1.5] [#Short Chain Fatty Acid
    - Decreases in the bacterially fermented metabolites of glycans, SCFAs, have been associated with IgE-mediated food allergy, providing an example of how dietary-driven microbiota changes can influence human health and disease
  • [1.6
    - #Cutibacterium > ferments hexoses > Embden–Meyerhof pathway > produce #Pyruvate > metabolized into propionate > reduce antigen presentation on dendritic cells as > GPR41-dependent modulation of hematopoiesis and affected allergic diseases in a mouse model
  • [1.7] [#Atopic Dermatitis] [#High-fiber diet
    - Epidemiological evidence indicates that children suffering from allergies have lower levels of dietary fibre-derived short-chain fatty acids (SCFA). Using an experimental model of AD-like skin inflammation, - a fermentable fibre-rich diet alleviates systemic allergen sensitization and disease severity. - particularly butyrate, which strengthens skin barrier function by altering mitochondrial metabolism of epidermal keratinocytes and the production of key structural components.
  • [1.8] [#Diabetes Type 1, #Infantile eczema
    #Infants treated with antibiotic > The early use of this treatment has been associated with higher risks of allergic diseases, eczema , and #Obesity, and type 1 diabetes
  • - #Exposure to pets increases the abundance of Ruminococcus and Oscillospira species, which may protect against allergic disorders and #Obesity in children
  • [1.9
    - #Siblings in the home to be one of the most important determinants of the developing microbiota in both the airway and gut, with significant differences in alpha diversity, beta diversity, and relative abundances of the most abundant taxa, with the specific associations being particularly apparent during the first year of life. - The age gap to the closest older sibling was more important than the number of older #Siblings. The signature of having #Siblings in the gut microbiota at 1 year was associated with protection against #Asthma at 6 years of age, while no associations were found for allergy.
  • [1.4] [#Inulin Consumption
    - diet of #Inulin fibre alters the composition of the mouse microbiota and the levels of microbiota-derived metabolites, notably #Bile Acids. - This metabolomic shift is associated with type 2 inflammation in the intestine and lungs, characterized by IL-33 production, activation of group 2 innate lymphoid cells and eosinophilia. - dietary #Inulin fibre triggers microbiota-derived #Cholic acid and type 2 inflammation at barrier surfaces