Disease ⇒ Psoriasis {40000128}
| Type: | Disease |
|---|---|
| Parent: | [ ] |
| Definition: | Psoriasis |
| Initialisation date: | 2020-09-06 |
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| Other Terms: | [ ] |
| MedDra ID: | 10037153 |
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| MedDra Level: | pt |
| ICD: | [ ] |
| Category: | Dermatology |
| Zone: | [ ] |
| Mechanism: | [ ] |
Notes:
- psoriatic lesions tend to have higher Firmicutes, Actinobacteria, and Corynebacterium kroppenstedtii. Both Staphylococci and Propionibacterium were present at lower levels, while Proteobacteria was present at higher levels in psoriasis than in healthy adults.
- Among bacterial species with higher abundance in the psoriasis gut microbiome, Bacteroides vulgatus and Parasutterella excrementihominis have been associated with other immune-mediated diseases.
- Increased intestinal colonization of Bacteroides vulgatus and elevated Bacteroides vulgatus reactive serum antibodies have been reported in ulcerative colitis patients.
- Moreover, colonization of Bacteroides vulgatus is sufficient to promote colitis in several animal models, which further supports the active role of Bacteroides vulgatus in development of colitis.
- The abundance of Akkermansia muciniphila was significantly reduced in patients with psoriasis .
- A. muciniphila is believed to have an important function in the pathogenesis of IBD and obesity; therefore, A. muciniphila, which is an indicator of health status, may be a key node for psoriasis as well as IBD and obesity. (1)
References Notes
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Shared Reference Notes
- [1.22]
- Altered gut barrier in psoriasis is associated with gastrointestinal symptoms, systemic inflammatory profile and the increased blood concentration of gut microbiota-derived metabolite – TMAO. - [1.23]
- Biologic therapy may have an impact on the composition of the gut microbiome of psoriatic patients. - [1.24] [#Multiple Sclerosis]
- Orally administered EDP1867, a gamma-irradiated strain of #Veillonella parvula, rapidly transits through the murine gut without colonization or alteration of the background microbiome flora. - In murine models of inflammatory disease including delayed-type hypersensitivity (DTH), #Atopic Dermatitis, psoriasis, and experimental autoimmune encephalomyelitis (EAE), treatment with EDP1867 resulted in significant reduction in inflammation and immunopathology. - [1.20] [#Akkermansia muciniphila]
- abundance of A. muciniphila was significantly decreased in patients with psoriasis. - In patients with moderate-to-severe psoriasis, serum markers of intestinal barrier integrity injury increased. - intestinal fatty acid binding protein, a biomarker of intestinal barrier damage, significantly elevated in patients with psoriasis. - [1.17]
- patients with psoriasis have a higher abundance of Proteobacteria and S. aureus and a decrease in Acinetobacter when compared to healthy individuals - [1.28] [#acute anterior uveitis, #Ankylosing spondylitis, #Crohn’s disease, #HLA-B27-associated disease, #Psoriatic Arthritis, #Ulcerative Colitis] [#Bacteroides vulgatus]
- HLA-B27 transgenic rats that develop a spontaneous spondyloarthropathy-like illness do not develop disease when raised in a germ-free environment, but mono-association with Phocaeicola vulgatus is sufficient to induce disease. - [1.29] [#Acne]
- [1.30]
- #Kocuria and #Cutibacterium were enriched in healthy subjects, while #Staphylococcus was enriched in psoriatic disease. - The relative abundance of #Corynebacterium was higher in NL #Psoriatic Arthritis (PsA). samples compared with NL psoriasis (PsO) samples. - [1.31]
- The psoriatic subject showed a decrease in Firmicutes abundance and an increase in Proteobacteria abundance. - An increase in Streptococcaceae, Rhodobacteraceae, Campylobacteraceae and Moraxellaceae has been observed in psoriatic subject.