Disease ⇒ Psoriasis {40000128}
Type: | Disease |
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Definition: | Psoriasis |
Parent: | [ ] |
Initialisation date: | 2020-09-06 |
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Other Terms: | [ ] |
MedDra ID: | 10037153 |
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MedDra Level: | pt |
ICD: | [ ] |
Category: | Dermatology |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
- Among bacterial species with higher abundance in the psoriasis gut microbiome, Bacteroides vulgatus and Parasutterella excrementihominis have been associated with other immune-mediated diseases.
- Increased intestinal colonization of Bacteroides vulgatus and elevated Bacteroides vulgatus reactive serum antibodies have been reported in ulcerative colitis patients.
- Moreover, colonization of Bacteroides vulgatus is sufficient to promote colitis in several animal models, which further supports the active role of Bacteroides vulgatus in development of colitis.
- The abundance of Akkermansia muciniphila was significantly reduced in patients with psoriasis .
- A. muciniphila is believed to have an important function in the pathogenesis of IBD and obesity; therefore, A. muciniphila, which is an indicator of health status, may be a key node for psoriasis as well as IBD and obesity. (1)
References Notes
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Shared Reference Notes
- [1.21]
- Altered gut barrier in psoriasis is associated with gastrointestinal symptoms, systemic inflammatory profile and the increased blood concentration of gut microbiota-derived metabolite – TMAO. - [1.22]
- Biologic therapy may have an impact on the composition of the gut microbiome of psoriatic patients. - [1.23]
- Orally administered EDP1867, a gamma-irradiated strain of Veillonella parvula, rapidly transits through the murine gut without colonization or alteration of the background microbiome flora.
- In murine models of inflammatory disease including delayed-type hypersensitivity (DTH), atopic dermatitis, psoriasis, and experimental autoimmune encephalomyelitis (EAE), treatment with EDP1867 resulted in significant reduction in inflammation and immunopathology. - [1.19]
- abundance of A. muciniphila was significantly decreased in patients with psoriasis.
- In patients with moderate-to-severe psoriasis, serum markers of intestinal barrier integrity injury increased.
- intestinal fatty acid binding protein, a biomarker of intestinal barrier damage, significantly elevated in patients with psoriasis. - [1.27]
- The psoriatic subject showed a decrease in Firmicutes abundance and an increase in Proteobacteria abundance.
- An increase in Streptococcaceae, Rhodobacteraceae, Campylobacteraceae and Moraxellaceae has been observed in psoriatic subject.