Disease ⇒ Psoriasis {40000128}

Record Keys
Type:	Disease
Definition:	Psoriasis
Parent:	[ ]

Details
Initialisation date:	2020-09-06
Other Terms:	[ ]

Links
Wickipedia Merck Manual

Meta Information
MedDra ID:	10037153
MedDra Level:	pt
ICD:	[ ]
Category:	Dermatology
Zone:	[ ]
Mechanism:	[ ]

Notes:

- Among bacterial species with higher abundance in the psoriasis gut microbiome, Bacteroides vulgatus and Parasutterella excrementihominis have been associated with other immune-mediated diseases.
- Increased intestinal colonization of Bacteroides vulgatus and elevated Bacteroides vulgatus reactive serum antibodies have been reported in ulcerative colitis patients.
- Moreover, colonization of Bacteroides vulgatus is sufficient to promote colitis in several animal models, which further supports the active role of Bacteroides vulgatus in development of colitis.
- The abundance of Akkermansia muciniphila was significantly reduced in patients with psoriasis .
- A. muciniphila is believed to have an important function in the pathogenesis of IBD and obesity; therefore, A. muciniphila, which is an indicator of health status, may be a key node for psoriasis as well as IBD and obesity. (1)

References Notes

[ ]

Shared Reference Notes

[1.21]
- Altered gut barrier in psoriasis is associated with gastrointestinal symptoms, systemic inflammatory profile and the increased blood concentration of gut microbiota-derived metabolite – TMAO.
[1.22]
- Biologic therapy may have an impact on the composition of the gut microbiome of psoriatic patients.
[1.23]
- Orally administered EDP1867, a gamma-irradiated strain of Veillonella parvula, rapidly transits through the murine gut without colonization or alteration of the background microbiome flora.
- In murine models of inflammatory disease including delayed-type hypersensitivity (DTH), atopic dermatitis, psoriasis, and experimental autoimmune encephalomyelitis (EAE), treatment with EDP1867 resulted in significant reduction in inflammation and immunopathology.
[1.19]
- abundance of A. muciniphila was significantly decreased in patients with psoriasis.
- In patients with moderate-to-severe psoriasis, serum markers of intestinal barrier integrity injury increased.
- intestinal fatty acid binding protein, a biomarker of intestinal barrier damage, significantly elevated in patients with psoriasis.
[1.27]
- The psoriatic subject showed a decrease in Firmicutes abundance and an increase in Proteobacteria abundance.
- An increase in Streptococcaceae, Rhodobacteraceae, Campylobacteraceae and Moraxellaceae has been observed in psoriatic subject.

↥ Abundance

‐ Actinomyces ‎Stool ‎Human [1.1]
‐ Alloiococcus ‎Skin swab ‎Human [1.2]
‐ Aspergillus ‎Skin swab ‎Human [1.3]
‐ Bacillus ‎Stool ‎Human [1.4]
‐ Bacteroides vulgatus ‎Gut Lumen ‎Human
‐ Bacteroides ‎Stool ‎Human [1.5]
‐ Bifidobacterium ‎Stool ‎Human [1.6]
‐ Blautia ‎Stool ‎Human [1.6]
‐ Brevibacterium ‎Skin swab ‎Human [1.3]
‐ Campylobacteraceae ‎Gut Lumen ‎Human
‐ Candida railensis ‎Skin swab ‎Human [1.3]
‐ Capnodiales ‎Skin swab ‎Human [1.3]
‐ Clostridium citroniae ‎Stool ‎Human [1.5]
‐ Collinsella aerofaciens ‎Stool ‎Human [1.1]
‐ Collinsella ‎Stool ‎Human [1.6]
‐ Comamonas ‎Skin swab ‎Human [1.2]
‐ Coprococcus ‎Stool ‎Human [1.1]
‐ Corynebacterium kroppenstedtii ‎Skin swab ‎Human [1.7]
‐ Corynebacterium simulans ‎Skin swab ‎Human [1.7]
‐ Cyanobacteria ‎Stool ‎Human [1.4]
‐ Dermabacter ‎Skin swab ‎Human [1.2]
‐ Dialister ‎Stool ‎Human [1.8]
‐ Dorea formicigenerans ‎Stool ‎Human [1.1]
‐ Dorea ‎Stool ‎Human [1.8]
‐ Enterococcus ‎Stool ‎Human [1.5]
‐ Faecalibacterium ‎Stool ‎Human [1.9]
‐ Finegoldia ‎Skin swab ‎Human [1.7]
‐ Flavobacterium ‎Skin swab ‎Human [1.2]
‐ Fretibacterium fastidiosum ‎Saliva ‎Human [1.10]
‐ Gallicola ‎Skin swab ‎Human [1.2]
‐ Geobacillus ‎Skin swab ‎Human [1.11]
‐ Gordonia ‎Skin swab ‎Human [1.3]
‐ Helcococcus ‎Skin swab ‎Human [1.2]
‐ Hyphomicrobium ‎Skin swab ‎Human [1.2]
‐ Kocuria palustris ‎Skin swab ‎Human [1.3]
‐ Lachnospiraceae ‎Stool ‎Human [1.4]
‐ Lactobacillales ‎Ameliorative ‎Gut Lumen ‎Human
‐ Lactococcus ‎Stool ‎Human [1.4]
‐ Larkinella ‎Skin swab ‎Human [1.2]
‐ Malassezia furfur ‎Skin swab ‎Human [1.12]
‐ Malassezia restricta ‎Psoriatic scale ‎Human [1.13]
‐ Malassezia restricta ‎Skin swab ‎Human [1.14]
‐ Malassezia sympodialis ‎Skin swab ‎Human [1.14]
‐ Marinicella ‎Skin swab ‎Human [1.2]
‐ Megasphaera ‎Stool ‎Human [1.8]
‐ Micrococcaceae ‎Skin swab ‎Human [1.2]
‐ Mogibacterium timidum ‎Saliva ‎Human [1.10]
‐ Moraxellaceae ‎Gut Lumen ‎Human
‐ Neisseriaceae ‎Skin swab ‎Human [1.7]
‐ Novosphingobium ‎Skin swab ‎Human [1.2]
‐ Parabacteroides ‎Stool ‎Human [1.4]
‐ Parasutterella excrementihominis ‎Gut Lumen ‎Human
‐ Pedobacter ‎Skin swab ‎Human [1.2]
‐ Penicillium ‎Skin swab ‎Human [1.3]
‐ Peptostreptococcus ‎Skin swab ‎Human [1.2]
‐ Prevotella ‎Skin swab ‎Human [1.15]
‐ Proteobacteria ‎Gut Lumen ‎Human
‐ Pseudomonas ‎Skin swab ‎Human [1.2]
‐ Rhodobacteraceae ‎Gut Lumen ‎Human
‐ Rhodocyclaceae ‎Skin swab ‎Human [1.2]
‐ Rhodotorula ‎Skin swab ‎Human [1.3]
‐ Roseateles ‎Skin swab ‎Human [1.2]
‐ Roseomonas ‎Skin swab ‎Human [1.2]
‐ Rothia dentocariosa ‎Saliva ‎Human [1.10]
‐ Rothia mucilaginosa ‎Saliva ‎Human [1.10]
‐ Ruminococcus gnavus ‎Stool ‎Human [1.1]
‐ Ruminococcus ‎Stool ‎Human [1.8]
‐ Slackia ‎Stool ‎Human [1.6]
‐ Sphingomonas ‎Skin swab ‎Human [1.2]
‐ Staphylococcus ‎Skin swab ‎Human [1.16]
‐ Streptococcaceae ‎Gut Lumen ‎Human
‐ Streptococcus ‎Skin swab ‎Human [1.17]
‐ Streptococcus ‎Tissue biopsie ‎Human [1.18]
‐ Subdoligranulum ‎Stool ‎Human [1.6]
‐ Sutterella ‎Stool ‎Human [1.4]
‐ Tanerella forsythia ‎Saliva ‎Human [1.10]
‐ Treponema denticola ‎Saliva ‎Human [1.10]
‐ Treponema ‎Saliva ‎Human [1.10]
‐ Vogesella ‎Skin swab ‎Human [1.2]
‐ Williamsia ‎Skin swab ‎Human [1.2]

↧ Abundance

‐ Akkermansia muciniphila ‎Stool ‎Human [1.5, 1.19]
‐ Alistipes ‎Stool ‎Human [1.6]
‐ Allobaculum ‎Stool ‎Human [1.4]
‐ Anaerococcus ‎Skin swab ‎Human [1.15]
‐ Aspergillus ‎Skin swab ‎Human [1.3]
‐ Bacteroides ‎Stool ‎Human [1.9]
‐ Bacteroidetes ‎Stool ‎Human [1.20]
‐ Barnesiella ‎Stool ‎Human [1.6]
‐ Burkholderia ‎Skin swab ‎Human [1.7]
‐ Carnobacterium ‎Stool ‎Human [1.4]
‐ Coprobacillus ‎Stool ‎Human [1.20]
‐ Coprococcus ‎Stool ‎Human [1.20]
‐ Coriobacteriaceae ‎Skin swab ‎Human [1.3]
‐ Cupriavidus ‎Skin swab ‎Human [1.11]
‐ Debaryomyces hansenii ‎Skin swab ‎Human [1.3]
‐ Ethanoligenens ‎Skin swab ‎Human [1.2]
‐ Faecalibacterium ‎Stool ‎Human [1.6]
‐ Firmicutes ‎Gut Lumen ‎Human
‐ Flavisolibacter ‎Skin swab ‎Human [1.11]
‐ Gordonibacter ‎Stool ‎Human [1.4]
‐ Granulicatella ‎Stool ‎Human [1.4]
‐ Lachnospiraceae ‎Stool ‎Human [1.20]
‐ Lachnospira ‎Stool ‎Human [1.1]
‐ Lactobacillus ‎Skin swab ‎Human [1.7]
‐ Macrococcus ‎Skin swab ‎Human [1.2]
‐ Malassezia globosa ‎Psoriatic scale ‎Human [1.13]
‐ Malassezia globosa ‎Skin swab ‎Human [1.14]
‐ Malassezia slooffiae ‎Skin swab ‎Human [1.3]
‐ Malassezia sympodialis ‎Skin swab ‎Human [1.3]
‐ Methylobacterium ‎Skin swab ‎Human [1.11]
‐ Mycoplasma faucium ‎Saliva ‎Human [1.10]
‐ Naganishia diffluens ‎Skin swab ‎Human [1.3]
‐ Parabacteroides ‎Stool ‎Human [1.20]
‐ Paraprevotella ‎Stool ‎Human [1.8]
‐ Penicillium miczynskii ‎Skin swab ‎Human [1.3]
‐ Penicillium ‎Skin swab ‎Human [1.3]
‐ Porphyromonas gingivalis ‎Saliva ‎Human [1.10]
‐ Prevotella copri ‎Stool ‎Human [1.1]
‐ Propionibacterium acnes ‎Skin swab ‎Human [1.7]
‐ Propionibacterium ‎Skin swab ‎Human [1.17]
‐ Propionibacterium ‎Tissue biopsie ‎Human [1.18]
‐ Rhodotorula ‎Skin swab ‎Human [1.3]
‐ Rothia ‎Stool ‎Human [1.4]
‐ Ruminococcaceae ‎Stool ‎Human [1.20]
‐ Schlegelella ‎Skin swab ‎Human [1.11]
‐ Staphylococcus ‎Tissue biopsie ‎Human [1.18]
‐ Streptococcus ‎Stool ‎Human [1.4]
‐ Sutterella ‎Stool ‎Human [1.8]
‐ Thermus ‎Stool ‎Human [1.4]
‐ Xanthobacteraceae ‎Skin swab ‎Human [1.3]
‐ Xanthomonadaceae ‎Skin swab ‎Human [1.11]

Related Factor

[ ]

Subclass

‐ [40000279] Psoriatic Arthritis

Related Metabolome

[ ]

References

(1) The Akkermansia muciniphila is a gut microbiota signature in psoriasis. [Abstract] [2018]

Common References

[1.1] Psoriatic patients have a distinct structural and functional fecal microbiota compared with controls [2019] [The Journal of Dermatology] [Journal] [80001222]
[1.2] Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization [2018] [Microbiome] [Journal] [80000829]
[1.3] Dysbiosis of skin microbiota in psoriatic patients: co-occurence of fungal and bacterial communities [2019] [Frontiers in Microbiology] [Journal] [80000984]
[1.4] Dysbiosis of gut microbiota was closely associated with psoriasis [2019] [Science China Life Sciences] [Journal] [80001218]
[1.5] The Akkermansia muciniphila is a gut microbiota signature in psoriasis [2018] [Experimental Dermatology] [Journal] [80000744]
[1.6] Gut microbiota dysbiosis in a cohort of patients with psoriasis [2019] [British Journal of Dermatology] [Journal] [80001039]
[1.7] Microbiome-host interplay in atopic dermatitis and psoriasis [2019] [Nature communications] [Journal] [80001261]
[1.8] Intestinal microbiota profiling and predicted metabolic dysregulation in psoriasis patients [2018] [Experimental Dermatology] [Journal] [80000895]
[1.9] Gut microbial composition in patients with psoriasis [2018] [Scientific Reports] [Journal] [80000690]
[1.10] Salivary microbiota and inflammation-related proteins in patients with psoriasis [2020] [Oral Diseases] [Journal] [80001398]
[1.11] Community differentiation of the cutaneous microbiota in psoriasis [2013] [Microbiome] [Journal] [80000364]
[1.12] Distribution of Malassezia species in patients with psoriasis and healthy individuals in Tehran, Iran [2008] [Journal of Cutaneous Pathology] [Journal] [80000765]
[1.13] Molecular characterization of the skin fungal microbiome in patients with psoriasis [2015] [Journal of Dermatology] [Journal] [80000758]
[1.14] Molecular analysis of fungal microbiota in samples from healthy human skin and psoriatic lesions [2006] [Journal of Clinical Microbiology] [Journal] [80000757]
[1.15] Combined culture and metagenomic analyses reveal significant shifts in the composition of the cutaneous microbiome in psoriasis [2019] [British Journal of Dermatology] [Journal] [80001047]
[1.16] Unexplored diversity and strain-level structure of the skin microbiome associated with psoriasis [2017] [npj Biofilms and Microbiomes] [Journal] [80000979]
[1.17] Substantial alterations of the cutaneous bacterial biota in psoriatic lesions. [2008] [PLOS ONE] [Journal] [80000247]
[1.18] Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin. [2012] [Arch Dermatol Res] [Journal] [80000365]
[1.19] Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions [2021] [Review] [Frontiers in Immunology] [Journal] [80002377]
[1.20] Decreased bacterial diversity characterizes an altered gut microbiota in psoriatic arthritis and resembles dysbiosis of inflammatory bowel disease. [2015] [Arthritis Rheumatol] [Journal] [80000525]
[1.21] Clinical Implications of Intestinal Barrier Damage in Psoriasis [2021] [Research] [Dovepress] [Journal] [80001598]
[1.22] Gut microbiome profile in psoriatic patients treated and untreated with biologic therapy [2021] [Abstract] [The Journal of Dermatology] [Journal] [80001609]
[1.23] Regulation of Peripheral Inflammation by a Non-Viable, Non-Colonizing Strain of Commensal Bacteria [2022] [Research] [Frontiers in Immunology] [Journal] [80002315]
[1.24] The Human Skin Microbiome in Selected Cutaneous Diseases [2022] [Review] [Frontiers in Cellular and Infection Microbiology] [Journal] [80002353]
[1.25] Gut–Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis [2022] [Review] [biomedicines] [Journal] [80002408]
[1.26] Dietary Intervention and Supplements in the Management of Psoriasis: Current Perspectives [2022] [Review] [Psoriasis: Targets and Therapy] [Journal] [80002452]
[1.27] Skin microbiota of first cousins affected by psoriasis and atopic dermatitis [2016] [Review] [Clinical and Molecular allergy] [Journal] [80000013]

Disease ⇒ Psoriasis {40000128}

Record Keys

Details

Links

Meta Information

Notes:

References Notes

Shared Reference Notes

Common References