Microbiome & Chronic Diseases

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Porphyromonas ⇒ Porphyromonas gingivalis {10000232}

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Porphyromonas gingivalis


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- Porphyromonas gingivalis (Pg), dampens interferon (IFN) signaling in a manner that is strikingly similar to IFN suppression employed by multiple viral pathogens

References Notes

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Shared Reference Notes

  • [1.22
    - Anti‐Porphyromonas gingivalis (Pg) antibody titers positively correlated with intramuscular adipose tissue content (IMAC), fasting blood glucose, and HOMA‐IR in metabolic syndrome patients. - Pg administration altered the gut microbiome, particularly by decreasing the abundance of genus Turicibacter.
  • [1.23
    - The Gram-negative bacterium Porphyromonas gingivalis is a secondary colonizer of the oral biofilm and is involved in the onset and progression of periodontitis.
  • [1.24] [#Oral Administration of P. gingivalis
    - Even a single administration of oral P. gingivalis can increase the prevalence of Bacteroidetes while decreasing the abundance of Firmicutes
  • [#Rheumatoid Arthritis] - The presence of P. gingivalis in the GI microbiota has been linked with a milieu of inflammatory/autoimmune diseases associated with GI dysbiosis including RA and NAFLD
  • [1.19] [#Rheumatoid Arthritis
    - Increased serum levels of the antibodies IgM rheumatoid factor (IgM-RF) and antibodies against #Citrullinated Proteins (ACPA) in healthy individuals imply an elevated risk of developing RA - The possible role of Porphyromonas gingivalis in the immunopathogenesis of RA has been of particular interest due to its capacity to generate #Citrullinated Proteins.
  • [1.25] [#Alzheimer’s disease
    - tau to be a target of gingipain proteolysis and suggested that tau pathology in AD brains may be caused by transneural spread of P. gingivalis, tau damage by gingipain proteolysis, and activation of human proteases. They also hypothesized that #Gingipains might be a driver of a compensatory increase in tau production of AD patients.
  • [1.21] [#Periodontal disease] [#Secretory calcium-binding phosphoprotein proline-g
    - Secretory calcium-binding phosphoprotein proline-glutamine rich 1 (SCPPPQ1), a protein normally produced by the gingival epithelium to mediate its attachment to teeth, was suggested to be bactericidal. - Incubation of Porphyromonas gingivalis, a major periodontopathogen, with the full-length protein resulted in decrease in bacterial number, formation of aggregates and membrane disruptions.
  • [1.20] [#Multiple Sclerosis, #Periodontal disease] [#Lipopolysaccharide
    - in periodontitis-diseased tissues, P. gingivalis was present, but not much LPS was evident in tissues. - these bacterial lipids accumulate in structures in blood vessels that can lead to thickening or blockages called atheromas. - in the blood of MS patients, and they found that the bacterial lipid levels were lower in MS patients, a very surprising result. They expected, if anything, that patients with the autoimmune disease would have more lipid present.
  • [1.26
    - Porphyromonas gingivalis (Pg), dampens interferon (IFN) signaling in a manner that is strikingly similar to IFN suppression employed by multiple viral pathogens. - Pg suppressed IFN production by down-regulating several IFN regulatory factors (IRFs 1, 3, 7, and 9), proteolytically degrading STAT1 and suppressing the nuclear translocation of the ISGF3 complex, resulting in profound and systemic repression of multiple IFN-stimulated genes.
  • [1.27] [#Diabetic Retinopathy
    - exposure to Porphyromonas gingivalis increases the risk for early DR
  • [1.28] [#Alzheimer’s disease] [#Amyloid-beta, #Gingipains
    - AβPP is an infection responsive protein cleaved via the amyloidogenic pathway on exposure to conditioned medium and in the presence of pro-inflammatory mediators.
  • [1.29] [#Alzheimer’s disease
    - nerve cells in the brain contain a type of protein called tau. When tau meets the #Gingipains enzyme, the tau released from the nerve cell. Once freed, tau physically changes, in the form of coils and non-coiling filaments. These filaments of tau then re-attach to the nerve cell and become incorporated into the lesion known as neurofibrillary tangles. - once a nerve cell dies and the free tau protein leaks into the brain, the tau may attach itself to healthy neighboring nerve cells, repeating the process and leading to further damage to the brain as the disease spreads
  • [1.30] [#Alzheimer’s disease
    - Local periodontal inflammation due to infection with #Helicobacter pylori, the agent of gastric ulcers, or with Porphyromonas gingivalis, in fact, can stimulate brain tissue inflammation

Common References