Aggregatibacter ⇒ Aggregatibacter actinomycetemcomitans {10000870}
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| Definition: | Aggregatibacter actinomycetemcomitans |
| Initialisation date: | [ ] |
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| Rank: | Species |
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| Domain: | Bacteria |
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| Enzyme: | [ ] |
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Shared Reference Notes
- [1.1] [#Chronic periodontitis, #Periodontal disease]
- Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (#Leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to #Rheumatoid Arthritis. - Aa has been proposed as a link between periodontitis and autoimmunity in #Rheumatoid Arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs). - [1.2] [#Enterobacteriaceae bacterium]
- the oral bacterium in the duodenum may be capable of entering the pancreas. For instance, the periodontal microbes (#Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans) have been proven positively related to #Pancreatic Cancer risk
References Notes
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