Sulfide {60000040}

Record Keys


Parent:[  ]
Definition:
Sulfide
Queue:[  ]

Details


Initialisation date:
2020-09-17
Specification:
[  ]
Source:
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Links


Meta Information


Structural Type:
Inorganic
Functional Type:[  ]
Function:
Pro-inflammatory, Oncogenesis, Genotoxin

Notes:


[  ]

Shared Reference Notes


  • [1.1
    - Gut microbiota metabolize taurine and produce hydrogen sulfide gas. - Hydrogen sulfide inhibits aerobic respiration, and can thereby block the growth of harmful bacteria.
  • [1.2
    - #Animal-based diet could enrich the gut microbiome–encoding sulfite reductases and sulfite-reducing bacteria which generate hydrogen sulfide in sulfur metabolism, a harmful by-product that may induce DNA damage, disrupt the mucus bilayer, and promote inflammation and CRC.
  • [1.3] [#Hydrogen sulfide
    - Some oral #Bacteria (e.g., #Porphyromonas gingivalis, #Prevotella intermedia, #Aggregatibacter actinomycetemcomitans, and #Fusobacterium nucleatum) produce volatile #Sulfur compounds (VSCs), such as hydrogen sulfide (H2S), methyl mercaptan (CH3SH), dimethyl sulfide ((CH3)2S), and dimethyl disulfide (CH3SSCH3).
  • - H2S is a known genotoxic agent and may lead to genomic instability or cumulative mutations. - Increased expression of various H2S-producing enzymes has been observed in #Cancer cells, particularly in cancers of the colon and ovaries. - Overexpression of cystathionine-β-synthase causes the production of increased amounts of H2S, which affect tumor growth and spread by activation of proliferation, migration, and invasive signaling pathways, and enhance tumor angiogenesis

References Notes


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Common References


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