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Disease ⇒ Cancer ⇒ Pancreatic Cancer {40000169}

Record Keys


Type:
Disease
Parent:
Definition:
Pancreatic Cancer

Details


Initialisation date:
2019-08-04
Other Terms:[  ]

Links


Meta Information


MedDra ID:
10033609
MedDra Level:
pt
ICD:[  ]
Category:
Gastroenterology, Oncology
Zone:[  ]
Mechanism:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.12] [#Lactobacillus] [#Indole, #Tryptophan] [#Probiotic
  • [1.13] [#kynurenine
  • [1.4
    -Veillonella atypica, Fusobacterium nucleatum/hwasookii and Alloscardovia omnicolens were enriched in faeces of patients with PDAC, whereas Romboutsia timonensis, Faecalibacterium prausnitzii, Bacteroides coprocola and Bifidobacterium bifidum species clusters were depleted. In contrast, we did not detect any species with significantly differential abundance in the salivary microbiome when correcting for multiple tests, including previously reported associations, such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans,22 Neisseria elongata or Streptococcus mitis
  • [1.7
    - Deletion of Col1 homotrimers increases overall survival of mice with pancreatic ductal adenocarcinoma (PDAC), associated with reprograming of the tumor microbiome with increased microaerophilic #Campylobacterales, which can be reversed with broad-spectrum antibiotics.
  • [1.14
    - in a mouse model of PDA, #Malassezia from the colon infiltrated and accelerated PDA, a condition that was reversed with antifungal treatment.
  • [1.11] [#Tryptophan
    - dietary Trp generated by the gut microbiota activate the aryl hydrocarbon receptor in myeloid cells, promoting an immune suppressive tumor microenvironment and facilitating pancreatic ductal adenocarcinoma growth.
  • [1.15] [#Breast cancer, #Ovarian cancer
    - Fungi were detected in 35 #Cancer types and were often intracellular. - 0%–25% of the tumors per #Cancer type to be positive for either β-glucan or Aspergillus staining. - fungal staining was mainly evident within #Cancer cells in pancreatic, breast, and ovarian #Cancer, it mostly localized to macrophages in #Melanoma and lung cancers
  • [1.5
    - gut microbe–derived metabolite trimethylamine N-oxide (#TMAO), enhanced antitumor immunity to Pancreatic ductal adenocarcinoma (PDAC) - Delivery of #TMAO intraperitoneally or via a dietary choline supplement to orthotopic PDAC-bearing mice reduced tumor growth, associated with an immunostimulatory tumor-associated macrophage (TAM) phenotype, and activated effector T cell response in the tumor microenvironment. - #TMAO potentiated the type I interferon (IFN) pathway and conferred antitumor effects in a type I IFN–dependent manner. - bacteria producing an enzyme that generates #TMA was associated with positive immunotherapy outcomes in people with pancreatic cancer. - #Bacillus and #Paenibacillus species, were present at higher levels in people who survived for a long period of time after pancreatic cancer.
  • [1.16] [#Bacteroides fragilis toxin
    - Enterotoxigenic #Bacteroides fragilis (ETBF) produces #Bacteroides fragilis toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and #Colorectal cancer (CRC).
  • [1.17
    -The long-term survivors showed a relative abundance of Pseudoxanthomonas, Saccharropolyspora and Streptomyces. The presence of all three taxa, as well as the species Bacillus Clausii, predicted better outcomes for patients.

Common References