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Disease ⇒ Pancreatic Cancer ⇒ Cancer {40000169}

Record Keys


Type:
Disease
Definition:
Pancreatic Cancer
Parent:

Details


Initialisation date:
2019-08-04
Other Terms:[  ]

Links


Meta Information


MedDra ID:
10033609
MedDra Level:
pt
ICD:[  ]
Category:
Gastroenterology, Oncology
Zone:[  ]
Mechanism:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.11] [#Lactobacillus] [#Indole, #Tryptophan] [#Probiotic
  • [1.12] [#kynurenine
  • [1.4
    -Veillonella atypica, Fusobacterium nucleatum/hwasookii and Alloscardovia omnicolens were enriched in faeces of patients with PDAC, whereas Romboutsia timonensis, Faecalibacterium prausnitzii, Bacteroides coprocola and Bifidobacterium bifidum species clusters were depleted. In contrast, we did not detect any species with significantly differential abundance in the salivary microbiome when correcting for multiple tests, including previously reported associations, such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans,22 Neisseria elongata or Streptococcus mitis
  • [1.6
    - Deletion of Col1 homotrimers increases overall survival of mice with pancreatic ductal adenocarcinoma (PDAC), associated with reprograming of the tumor microbiome with increased microaerophilic #Campylobacterales, which can be reversed with broad-spectrum antibiotics.
  • [1.13
    - in a mouse model of PDA, #Malassezia from the colon infiltrated and accelerated PDA, a condition that was reversed with antifungal treatment.
  • [1.10] [#Tryptophan
    - dietary Trp generated by the gut microbiota activate the aryl hydrocarbon receptor in myeloid cells, promoting an immune suppressive tumor microenvironment and facilitating pancreatic ductal adenocarcinoma growth.
  • [1.14
    -The long-term survivors showed a relative abundance of Pseudoxanthomonas, Saccharropolyspora and Streptomyces. The presence of all three taxa, as well as the species Bacillus Clausii, predicted better outcomes for patients.

Common References