Microbiome & Chronic Diseases

Evidence Based Medicine
Sign in

Bacteroides ⇒ Bacteroides fragilis {10000104}

Record Keys

Bacteroides fragilis


Initialisation date:


Meta Information

Zone:[  ]
Enzyme:[  ]
Mucin-degrading, Cancerogenic, Anti-inflammatory


[  ]

References Notes

[  ]

Shared Reference Notes

  • [1.39
    - The immunomodulatory molecule polysaccharide A derived from the human commensal Bacteroides fragilis mediates the conversion of CD4+ T cells into FOXP3+ Treg cells that produce IL-10 during commensal colonization, stimulating immunological development within mammalian hosts
  • [1.40
    - During colonization of animals with the ubiquitous gut microorganism Bacteroides fragilis, a bacterial polysaccharide (PSA) directs the cellular and physical maturation of the developing immune system, correcting systemic T cell deficiencies and TH1/TH2 imbalances and directing lymphoid organogenesis. - PSA presented by intestinal dendritic cells activates CD4+ T cells and elicits appropriate cytokine production.
  • [1.41] [#Multiple Sclerosis
    - Addition of a single probiotic bacterial species, Bacteroides fragilis Depending on Polysaccharide A Expression, can ameliorate MS disease through immunomodulation .
  • [1.36] [#Cancer] [#Bacteroides fragilis toxin
    - Bacteroides fragilis toxin (Bft), can indirectly damage the host DNA by eliciting high levels of reactive oxygen species (ROS)
  • [1.3] [#Colon polyps] [#Lipopolysaccharide
    - BF is enriched in patients with polyps > inflammatory cytokines in the mucosa adjacent to polyps. - BF from polyps is enriched for LPS biosynthesis genes, activates TLR4, and induces IL-12 > induce a pro-inflammatory response. - Presence of LPS genes and elevated expression of LPS are found in polyp tissues.
  • [1.42
    - The colon has two distinct mucus structures: the outer layer is colonized by mucin-degrading bacteria and is characterized by the presence of Bacteroides acidifaciens, Bacteroides fragilis, Bifidobacteriaceae and Akkermansia muciniphila and the inner layer and crypts are penetrated at low density by a more restricted community that includes Bacteroides fragilis and Acinetobacter spp.
  • [1.43
    - #Sulforaphane can normalize the intestinal flora imbalance of #Bladder cancer mice with a significant increase in Bacteroides fragilis and #Clostridium cluster I
  • [1.38] [#Alzheimer’s disease] [#Amyloid-beta
    - Presence of #Amyloid deposits was associated with greater abundance of proinflammatory taxa (#Escherichia/#Shigella), which were in turn correlated with proinflammatory cytokines, and with reduced abundance of #Eubacterium rectale and B. fragilis, 2 taxa with anti-inflammatory activity
  • - Bacteroides fragilis metabolite #Polysaccharide A has anti-inflammatory properties,
  • [1.37] [#Alzheimer’s disease] [#Lipopolysaccharide
    - Bacteroides fragilis in the human gastrointestinal (GI) tract generates > neurotoxin #BF-LPS > #BF-LPS leaks out of the GI tract, crosses the blood brain barrier via the circulatory system, and accesses brain compartments > inreases inflammation in brain cells and inhibits neuron-specific neurofilament light (NF-L,) a protein that supports cell integrity > deficiency of NF-L > consequent atrophy of the neuronal cytoskeleton and the disruption of synaptic organization.
  • [1.35
    - #Bacteroides thetaiotaomicron, #Akkermansia muciniphila, Ruminoccous gnavus, Bacteroides fragilis, and #Bifidobacterium bifidium are predominant bacteria within the mucus layer that utilize #Glycans as their energy source by glycosidase, sulphatase, and sialidase enzymes
  • [1.44
    - Bacteroides fragilis and several #Clostridia species have been reported to cause an anti-inflammatory response
  • [1.45] [#Pancreatic Cancer] [#Bacteroides fragilis toxin
    - Enterotoxigenic Bacteroides fragilis (ETBF) produces Bacteroides fragilis toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and #Colorectal cancer (CRC).

Common References