Disease ⇒ Breast cancer ⇒ Cancer {40000376}

References Notes

Shared Reference Notes

• [1.8] 
  - The abundance of #Akkermansia muciniphila, as a key player of #Propionate production, is associated with the richness of the gut microbiota in patients with Breast cancer]
• - The proportions of #Blautia and F. Prausnitzii and absolute numbers of #Blautia and Bifidobacterium species in the gut microbiome are directly correlated with the clinical stage of Breast cancer]. - For instance, patients with stage 1 Breast cancer] had a lower number of gut #Blautia sp. in comparison with the ones with stage grade 3
• - #Cadaverine as a biogenic amine is formed through the direct decarboxylation of L-lysine. - It is reported that #Cadaverine biosynthesis is reduced in the gut in early-stage Breast cancer], resulting in lower production of an anti-cancer bacterial metabolite and reduced BC invasion
• - #Enterolactone may act as a selective modulator of estrogen signaling and may be associated with lowering the risk of BC.
• [#Antibiotic Therapy] - Overuse of antibiotics might reduce the plasma level of lignan #Enterolactone; therefore, it might directly affect the microbiome populations and increase the BC risk
• - Estrobolome, the bacterial gene mass in the human intestine, the products of which take part in estrogens metabolism, may increase the risk of #Estrogen receptor-positive BC in postmenopausal females. - Changes in gut microbiome composition may lead to the #Estrogen metabolism alternation and affect the BC risk.
• - #Lithocholic acid can inhibit Breast cancer progression, epithelial-mesenchymal transition, and metastasis via activation of nuclear factor erythroid 2-related factor 2 (NRF2) and other proteins involved in the antioxidant defense system.
• [#Plant-based diet] - Intestinal bacteria can turn some plant lignans such as flaxseed, sunflower, caraway, pumpkin, legumes, and soybean, into mammalian lignans with protective effects against Breast cancer]. - High consumption of raw vegetables showed a significant protective effect against BC risk.
• [#Short Chain Fatty Acid] - Propionate, acetate, and butyrate are the three most predominant SCFAs and are well-known modulators for cell invasion and apoptosis in Breast cancer.
• [1.9] [#Antibiotic Therapy] 
  - Antibiotic-induced perturbation of the gut microbiota > increases tumor progression in multiple BrCa mouse models > increased number of cells with a stromal signature in tumors > increased abundance of mast cells in the tumor stromal regions. - Re-supplementation of antibiotic-treated mice with #Faecalibaculum rodentium > restored tumor growth to control levels - Mast cell stabilizer, #Cromolyn > decreases tumor growth only in antibiotic treated animals
• [1.10] [#Photobiomodulation] 
• [1.11] [#Colorectal cancer] [#Hydrogen sulfide] 
  - H2S at a safe and nontoxic concentration can protect not only healthy cells, such as neurons, but also cancerous cells from apoptosis. - In a variety of cancers, including ovarian #Cancer, oral #Cancer, thyroid #Cancer, colon #Cancer, breast #Cancer, etc., the upregulation of H2S-producing enzyme CBS > can enhance the proliferation ability of #Cancer cells and make #Cancer cells more sensitive to it
• - #Fucoidan > increasing the diversity of the intestinal flora composition and increasing the Bacteroidetes/Firmicutes phylum ratio > can restore intestinal wall damage in mice > prevent the occurrence of breast cancer
• [1.12] 
  - Permutation testing with FDR control revealed taxa differences for fat% in Firmicutes, Bacilli, Bacillales, Staphylococcaceae and genus Staphylococcus, and fibrosis% in Firmicutes, Spirochaetes, Bacilli, Bacillales, Spirochaetales, Proteobacteria RF32, Sphingomonadales, Staphylococcaceae, and genera Clostridium, Staphylococcus, Spirochaetes, Actinobacteria Adlercreutzia.
• [1.13] 
  - Establishing commensal dysbiosis, defined as an inflammatory gut microbiome with low biodiversity, prior to breast tumor initiation, enhances early dissemination of hormone-receptor–positive (HR+) mammary tumor cells. - Commensal dysbiosis increased both the frequency and pro-fibrogenicity of mast cells in normal, non-tumor-bearing mammary tissues, a phenotypic change that persisted after tumor implantation.
• [1.14] [#Ovarian cancer, #Pancreatic Cancer] 
  - Fungi were detected in 35 #Cancer types and were often intracellular. - 0%–25% of the tumors per #Cancer type to be positive for either β-glucan or Aspergillus staining. - fungal staining was mainly evident within #Cancer cells in pancreatic, breast, and ovarian #Cancer, it mostly localized to macrophages in #Melanoma and lung cancers