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Escherichia ⇒ Escherichia coli {10000115}

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Escherichia coli


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- AICE (type of E. Coli ) may deteriorate or cause Gut lumen inflammation (Crohn’s disease) by using fucose and converting it to propionate.

References Notes

  • (1) [1.48

Shared Reference Notes

  • [1.14
    - AIEC bacteria uses 1,2-propanediol, a byproduct of the breakdown of fucose that is found in the lining of the intestines. - AIEC bacteria converts 1,2-propanediol to propionate.
  • [1.49] [#Food emulsifiers
    - Emulsifiers, widely used in processed food to improve food appearance, texture, and palatability due to their intrinsic properties. Emulsifiers affect the gut microbiota, disrupt the mucosal barrier, and promote inflammation; in mice models, they induce metabolic syndrome, colitis, and translocation of Escherichia coli.
  • [1.50] [#Anorexia nervosa
    - Bacterial chaperone protein Escherichia coli caseinolytic protease B (ClpB) and food-derived antigens were recently described to trigger the production of autoantibodies cross-reacting with appetite-regulating hormones and neurotransmitters.
  • [1.51
    - A #High-fat diet impairs mitochondrial uptake of oxygen into host enterocytes and elevates nitrate in the mucus, which in turn weakens healthy anaerobic gut function. Facultative anaerobes such as the pathobiont Escherichia coli become dominant, which leads to an overall increase in the amount of #Choline catabolized into the precursor for TMAO.
  • [1.52] [#Parkinson’s Disease
    - 38 E. coli genes promote neurodegeneration. - Two of these genes, csgA and csgB, code for proteins that form #Curli, one type of bacterial amyloid fibers. - #Curli cross-seeds and colocalizes with α-syn both in C. elegans neurons and human neuroblastoma cells. - #Curli-induced α-syn aggregations down-regulate mitochondrial genes, causing energy failure in neurons. - #Curli may have general effects in promoting neuropathologies induced by different aggregation-prone proteins, such as A-β in Alzheimer’s disease, Huntingtin in Huntington’s disease, and SOD1 in amyotrophic lateral sclerosis.
  • [1.53] [#Flagellin
    - Flagellins of the probiotic E. coli Nissle 1917 induce beta-defensin via Toll-like receptor 5.
  • [1.54
    - Adherent-invasive E. coli (AIEC), > prevalent in up to half the individuals with #Crohn’s disease (CD) - Among the genes related to AIEC pathogenicity, fim has the potential to generate an inflammatory reaction from the intestinal epithelial cells and macrophages, as it interacts with TLR4, inducing the production of inflammatory cytokines independently of LPS.
  • [1.55] [#Bacteriophage
  • [1.56] [#Lactoferrin
    - LF > binding with free iron >The lack of iron in Gut > suppresses the growth of Escherichia coli (E. coli.), an iron-dependent bacteria
  • [1.57] [#Inflamatory bowel disease] [#Salmonella typhimurium
    - adherent-invasive Escherichia coli (AIEC), and Salmonella enterica serovar Typhimurium > induce inflammation (through elevated T helper (TH) 1 and TH17 immune responses) in IBD animal model > fibrosis development. - in patients with #Crohn’s disease, AIEC strains > ileal mucosa > trigger the initiation or perpetuation of the inflammatory disease.
  • [1.58] [#Colorectal cancer
    - Increases in #Enterococcus faecalis and Escherichia coli enhance the production of intestinal inflammatory signaling molecules, IFN-γ and IL-4. In both IBD and CRC, #Fusobacterium nucleatum elicits strong pro-inflammatory responses
  • [1.59] [#Parkinson’s Disease
    - gut bacterial amyloid proteins, chiefly expression by curli proteins derived from Escherichia coli, promote the aggregation of α-syn in both the gut and the brain, resulting in behavioral deficits, intestinal dysfunction, and motor impairments
  • [1.60] [#Obesity] [#Lactobacillus animalis
    - several bacteria such as: #Methanobrevibacter smithii, #Bifidobacterium spp., #Bifidobacterium animalis, Escherichia coli, #Akkermansia muciniphila, #Anaerotruncus colihominis and bacteria of the Bacteroidetes strain have the capability to reduce the production of high-calorie substances and therefore also influence the caloric intake. A relatively low frequency of these bacteria correlates with increased body weight, as we have also observed.
  • [1.19
    - Oral gavages of #Klebsiella oxytoca, Escherichia coli, and #Cronobacter sakazakii belonging to Enterobacteriaceae, singly or together, caused dose-dependently #Colitis and #Depression-like behaviors in germ-free and specific-pathogen-free mice.
  • [1.61] [#Diabetes Type 2
    - LPS acts as a strong stimulant for the release of cytokines, which are key inducers of insulin resistance. - The bacterial #Lipopolysaccharide (LPS) from Escherichia coli has been shown to exhibit major effects on insulin sensitivity
  • [1.42] [#Colorectal cancer] [#Western-style diet
    - higher levels of #Polyketide synthase (pks+) Escherichia coli in tumors of those who relied on Western-style diets.
  • [1.8
    - Microbiota composition and predicted function in #Celiac Disease was largely determined by intestinal location. In the duodenum, but not stool, there was higher abundance of Escherichia coli, #prevotella salivae, and #Neisseria. - #Neisseria, an opportunistic pathogen previously found to be increased in patients with active #Celiac Disease, was associated with more severe enteropathy. - Expression of microbial glutamate carboxypeptidase was lower in the duodenum of celiac patients, and its decrease in mice also correlated with impaired gluten degradation, suggesting a potential candidate for future therapeutic development.
  • [1.45] [#Tryptophan
    - #Fucose increased the abundance of Trp-producing E. coli and normalized the blood Trp levels.
  • [1.62] [#Infants
    - Unique infant microbe-metabolite associations included positive correlations of #Enterococcus faecalis and E. coli with neurotransmitters #Tyramine and #Agmatine, respectively
  • [1.63] [#Parkinson’s Disease] [#Lipopolysaccharide
    - of the 29 species that are reduced in PD, only 1 is a canonical Gram-negative organism, #Prevotella copri, which interestingly, produces an LPS that not only does not induce inflammation, but can inhibit TLR4 activation by others. - Eleven of the 55 species that are enriched in PD are canonical Gram-negative organisms including those with highly stimulatory LPS (Escherichia coli, #Klebsiella species, and #Porphyromonas asaccharolytica).

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