Microbiome & Chronic Diseases

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Klebsiella ⇒ Klebsiella pneumoniae {10000643}

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Klebsiella pneumoniae


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Shared Reference Notes

  • [1.1
    - Prior gut infection increases the microbiota’s resistance to subsequent infection. - Sulfide sequestration unleashes endogenous respirers in the gut microbiota. - After infection by K. pneumoniae, the level of the molecule #Taurine rises in the gut. - #Taurine is produced from the metabolism of bile acids. . After infection, resident bacteria that can use #Taurine become more common in the gut.
  • [1.2] [#Inflamatory bowel disease] [#Bacteriophage
    - Klebsiella pneumoniae (Kp) strains are associated with IBD severity across geography. - A Kp-targeting five-phage combination suppresses intestinal inflammation in IBD models
  • [1.3] [#Pneumonia] [#Pseudomonas aeruginosa
    - Asymptomatic gut colonisation by Carbapenemase-producing Enterobacterales (CPE) leads to a specific gut dysbiosis and increases the severity of P. aeruginosa lung infection through lower numbers of alveolar macrophages and conventional dendritic cells. - CPE-associated dysbiosis is characterised by a near disappearance of the #Muribaculaceae family and lower levels of short-chain fatty acids.
  • [1.4
    - sufficient symbiotic microbe protection from #Bacteroidetes could prevent the host-to-host transmission and intestinal colonization of K. pneumoniae
  • [#Limosilactobacillus (Lactobacillus) reuteri] [#Short Chain Fatty Acid] - In the K. pneumoniae infection mice model, gut microbial composition (down-regulates Lactobacillus reuteri and #Bifidobacterium pseudolongum) and cecal metabolome (SCFAs) are altered
  • [#Inflamatory bowel disease] - saliva K. #Pneumonia of IBD patients rapidly establishes colonization in mice’s intestines, triggering a strong inflammatory response
  • [#Porphyromonas gingivalis] [#Lipopolysaccharide] - Cells of Paneth autonomously sense LPS via MyD88-dependent TLR, then stimulate antimicrobial cytokines and trigger the downstream NF-κB pathway, which subsequently regulates the production of Th17 cells or Tregs (LPS from P. gingivalis induces a stronger Th2 response while Klebsiella pneumoniae induces a stronger Th1 response)

References Notes

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Common References