Disease
Microbiota ☳
Metabolome
Factor
Enterobacteriaceae ⇒ Klebsiella {10000103}
Record Keys
Parent:
Definition: Klebsiella
Details
Initialisation date: 2020-09-06
Meta Information
Rank:
Domain:
Zone: [ ]
Enzyme: [ ]
Function: [ ]
Notes: Shared Reference Notes
[1.1 ] [#Hypertension ] #Succinate -producing bacteria and #Acetate -producing bacteria > respectively, lower and higher mean arterial pressure in mouse
- #Prevotella and Klebsiella > overrepresented in individuals with pHTN or HTN.
[1.2 ] Klebsiella can colonize the gut and result in severe gut inflammation in susceptible individuals, thereby exacerbating inflammatory disease
[1.3 ] [#Biliary tract cancer ] #Chronic cholecystitis and gallbladder #Cancer were those belonging to the #Enterobacteriaceae family. Klebsiella increased significantly in the order of normal, #Chronic cholecystitis , and gallbladder #Cancer .
[1.4 ] [#Premature infant ] Klebsiella overgrowth in the gut is highly predictive for brain damage in permature infants and is associated with a pro-inflammatory immunological tone.
[1.5 ] [#Parkinson’s Disease ] [#Lipopolysaccharide ] #Prevotella copri , which interestingly, produces an LPS that not only does not induce inflammation, but can inhibit TLR4 activation by others.
- Eleven of the 55 species that are enriched in PD are canonical Gram-negative organisms including those with highly stimulatory LPS (#Escherichia coli , Klebsiella species, and #Porphyromonas asaccharolytica ).
[1.6 ] Klebsiella species was significantly higher in patients with #Crohn’s disease and #Primary sclerosing cholangitis when compared with healthy controls.
- Several genes increased in the faecal microbiomes of patients with inflammatory bowel diseases > include hemolysin-coregulated protein and enzymes involved in fructose-, galactitol-, mannose-, and long-chain fatty acid-related uptake and metabolic pathways- were enriched in most faecal samples of the patients with inflammatory disease who carried Klebsiella species.
[1.7 ] [#Cesarean section ] #Children born by C-section demonstrate reduced colonization stability of #Bacteroides by day 14 and reduced abundance throughout infancy and up to 5 years of life.
- The low-#Bacteroides profile of neonates delivered by C-section is accompanied by an increased relative abundance of opportunistic pathogens (for example, #Enterococcus spp. and Klebsiella spp.)
[1.8 ] [#Human breast milk , #Vaginally delivery ] #Cesarean section -delivered (CSD) #Infants differed from those of vaginally delivered (VD) #Infants , with decreased #Bacteroides and #Escherichia -#Shigella and increased Klebsiella , #Veillonella , and #Enterococcus .
- At 6 months postpartum, these delivery mode-induced microbial shifts were restored by exclusive breastfeeding, resulting in similar gut microbial profiles between VD and CSD #Infants who were exclusively breastfed and more variable gut microbial profiles between VD and CSD #Infants who were mixed fed.
[1.9 ] #Bifidobacterium , #Slackia , #Enterococcus , Thiococcus, Klebsiella , #Serratia , and #Enterobacter abundances were also decreased with #Vitamin B6 supplementation in #Lactose -intolerant patients .
- #Sulfur -metabolism pathways were found to be one of the frequent pathways among certain member of #Cancer -increased taxa such as #Aquabacterium , #Bilophila wadsworthia , #Delftia , #Desulfovibrio , #Escherichia coli , #Fusobacterium , Klebsiella , #Lactobacillus , #Morganella , #Odoribacter , and #Proteus .
[1.11 ] #Hydrogen sulfide may suppress the #Oxygen -dependent metabolism of some pathogens
- #Taurinivorans muris has a protective role against Klebsiella and #Salmonella , two important gut pathogens.
[1.12 ] #TMAO in cystic fluid were positively correlated with bacterial clusters corresponding to Enterobacteriacea, #Granulicatella , Klebsiella , #Stenotrophomonas , #Streptococcus , #Haemophilus , and #Fusobacterium > associated with #Pancreatic Cancer .
[1.13 ] #Primary biliary cirrhosis were found to show enrichment of #Actinobacteria , #Lactobacillales , #Streptococcus , Klebsiella and #Veillonella
Intervention in Disease
Author: MetaBiomIdentifier: 10000103URL: https://www.metabiom.org/microbiota/2/klebsiellaKeywords: Microbiome, Dysbiosis, Microbiota, Organism, Bacteria
Common References
[1.1 ] Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats 80000153 ]
[1.2 ] Ectopic gut colonization: a metagenomic study of the oral and gut microbiome in Crohn’s disease 80001846 ]
[1.3 ] Association of Microbial Dysbiosis with Gallbladder Diseases Identified by Bile Microbiome Profiling 80001976 ]
[1.4 ] Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage 80002063 ]
[1.5 ] Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms 80002696 ]
[1.6 ] Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation 80000027 ]
[1.7 ] Gut microbiome immaturity and childhood acute lymphoblastic leukaemia 80003007 ]
[1.8 ] A health-promoting role of exclusive breastfeeding on infants through restoring delivery mode-induced gut microbiota perturbations 80003235 ]
[1.9 ] B Vitamins and Their Roles in Gut Health 80003304 ]
[1.10 ] Reproducible and opposing gut microbiome signatures distinguish autoimmune diseases and cancers: a systematic review and meta-analysis 80003358 ]
[1.11 ] Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut 80003445 ]
[1.12 ] A blood-based metabolomic signature predictive of risk for pancreatic cancer 80003462 ]
[1.13 ] Gut Microbiome and Metabolome Were Altered and Strongly Associated With Platelet Count in Adult Patients With Primary Immune Thrombocytopenia 80003463 ]
[1.14 ] Skin microbiome differences relate to the grade of acne vulgaris 80001179 ]
[1.15 ] Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption 80001029 ]
[1.16 ] The airway microbiome in patients with severe asthma: associations with disease features and severity 80000408 ]
[1.17 ] The gut microbiome in atherosclerotic cardiovascular disease 80000614 ]
[1.18 ] Alterations of gut microbiome in autoimmune hepatitis 80001159 ]
[1.19 ] Gut microbial profile in biliary atresia: a case-control study 80001225 ]
[1.20 ] Duodenal and faecal microbiota of celiac children: molecular, phenotype and metabolome characterization. 80000529 ]
[1.21 ] Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease 80000791 ]
[1.22 ] Composition of gut microbiota in patients with toxigenic Clostridioides (Clostridium) difficile: Comparison between subgroups according to clinical criteria and toxin gene load 80001022 ]
[1.23 ] Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer 80000305 ]
[1.24 ] Alterations in the gut microbiome and metabolism with coronary artery disease severity_DUBLICATE 80001002 ]
[1.25 ] Inflammation-related differences in mucosa-associated microbiota and intestinal barrier function in colonic Crohn’s disease 80000896 ]
[1.26 ] Relationship between alterations of urinary microbiota and cultured negative lower urinary tract symptoms in female type 2 diabetes patients 80001099 ]
[1.27 ] Intestinal microbiota is altered in patients with gastric cancer from Shanxi Province, China 80001028 ]
[1.28 ] Dysbiosis of fecal microbiota and high frequency of Citrobacter, Klebsiella spp., and Actinomycetes in patients with irritable bowel syndrome and gastroenteritis 80000589 ]
[1.29 ] Microbiome and its relation to gestational diabetes 80000966 ]
[1.30 ] Gut microbiome alterations in hereditary angioedema 80002296 ]
[1.31 ] Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism 80000345 ]
[1.32 ] Gut microbiota dysbiosis contributes to the development of hypertension 80000033 ]
[1.33 ] Molecular assessment of differences in the duodenal microbiome in subjects with irritable bowel syndrome 80000415 ]
[1.34 ] Microbiome analytics of the gut microbiota in patients with juvenile idiopathic arthritis: a longitudinal observational cohort study 80001040 ]
[1.35 ] Characterization of microbiota in male infertility cases uncovers differences in seminal hyperviscosity and oligoasthenoteratozoospermia possibly correlated with increased prevalence of infectious bacteria 80000723 ]
[1.36 ] A microbiome case-control study of recurrent acute otitis media identified potentially protective bacterial genera 80000688 ]
[1.37 ] Gut microbial profile analysis by MiSeq sequencing of pancreatic carcinoma patients in China 80000728 ]
[1.38 ] Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease 80000645 ]
[1.39 ] Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy 80000594 ]
[1.40 ] Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis 80000583 ]
[1.41 ] Faecal microbiota study reveals specific dysbiosis in spondyloarthritis 80000813 ]
[1.42 ] Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: a cross-sectional study 80000800 ]
[1.43 ] The bacterial communities of the small intestine and stool in children with short bowel syndrome 80001208 ]
[1.44 ] Fecal microbiota signatures of adult patients with different types of short bowel syndrome 80000662 ]
[1.45 ] Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus 80000460 ]
[1.46 ] Alterations in the gut microbiota and metabolite profiles of thyroid carcinoma patients 80000975 ]
[1.47 ] Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis. 80000612 ]
[1.48 ] Skin microbiome differences in atopic dermatitis and healthy controls in Egyptian children and adults, and association with serum immunoglobulin E 80001201 ]
[1.49 ] Altered intestinal microbiota associated with colorectal cancer 80001232 ]
[1.50 ] Fungal dysbiosis in mucosa-associated microbiota of Crohn’s disease patients 80000760 ]
[1.51 ] Dysbiosis of urinary microbiota is positively correlated with type 2 diabetes mellitus 80000429 ]
[1.52 ] Analysis of by high-throughput sequencing: Helicobacter pylori infection and salivary microbiome 80001404 ]
[1.53 ] Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma 80000859 ]
[1.54 ] Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure 80000785 ]
[1.55 ] Altered gut microbiota composition associated with eczema in infants 80000741 ]
[1.56 ] Alterations in the gut bacterial microbiome in fungal keratitis patients 80000884 ]
[1.57 ] Intestinal microbial ecology in premature infants assessed with non-culture-based techniques 80001077 ]
[1.58 ] The association between gut microbiota composition and body mass index in Chinese male college students, as analyzed by next-generation sequencing 80001120 ]
[1.59 ] Alterations of urinary microbiota in type 2 Diabetes Mellitus with hypertension and/or hyperlipidemia 80000661 ]
[1.60 ] Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery 80002685 ]
