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Microbiome & Chronic Diseases

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Disease ⇒ Coronary artery disease {40000234}

Record Keys


Type:
Disease
Definition:
Coronary artery disease
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:
CAD

Meta Information


MedDra ID:
10011078
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


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Shared Reference Notes


  • [1.7
    - Long-term increases in TMAO were associated with higher CHD risk, and repeated assessment of TMAO over 10 years improved the identification of people with a higher risk of CHD.
    - Diet may modify the associations of ΔTMAO with CHD risk
  • [1.8
    - TMAO levels are also associated with heart failure and coronary artery disease.
    - TMAO enhances the responsiveness of platelets to multiple agonists, promoting platelet hyperactivity and thus thrombosis and subsequent cardiovascular disease.
  • - Bilophila, a genus of gut microbes, can metabolize TMA, resulting in lower TMAO,58 suggesting that differences in TMA-metabolizing gut bacteria in individuals lead to different ultimate effects, and replacement of relevant bacteria may reduce the risk from TMAO.