Disease ⇒ Coronary artery disease {40000234}
Type: | Disease |
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Definition: | Coronary artery disease |
Parent: | [ ] |
Initialisation date: | [ ] |
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Other Terms: | CAD |
MedDra ID: | 10011078 |
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MedDra Level: | pt |
ICD: | [ ] |
Category: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.7]
- Long-term increases in TMAO were associated with higher CHD risk, and repeated assessment of TMAO over 10 years improved the identification of people with a higher risk of CHD.
- Diet may modify the associations of ΔTMAO with CHD risk - [1.8]
- TMAO levels are also associated with heart failure and coronary artery disease.
- TMAO enhances the responsiveness of platelets to multiple agonists, promoting platelet hyperactivity and thus thrombosis and subsequent cardiovascular disease. - - Bilophila, a genus of gut microbes, can metabolize TMA, resulting in lower TMAO,58 suggesting that differences in TMA-metabolizing gut bacteria in individuals lead to different ultimate effects, and replacement of relevant bacteria may reduce the risk from TMAO.