Disease ⇒ Coronary artery disease {40000234}

Record Keys
Type:	Disease
Definition:	Coronary artery *disease*
Parent:	[ ]

Details
Initialisation date:	[ ]
Other Terms:	CAD

Meta Information
MedDra ID:	10011078
MedDra Level:	pt
ICD:	[ ]
Category:	[ ]
Zone:	[ ]
Mechanism:	[ ]

Notes:

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References Notes

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Shared Reference Notes

[1.7]
- Long-term increases in TMAO were associated with higher CHD risk, and repeated assessment of TMAO over 10 years improved the identification of people with a higher risk of CHD.
- Diet may modify the associations of ΔTMAO with CHD risk
[1.8]
- TMAO levels are also associated with heart failure and coronary artery disease.
- TMAO enhances the responsiveness of platelets to multiple agonists, promoting platelet hyperactivity and thus thrombosis and subsequent cardiovascular disease.
- Bilophila, a genus of gut microbes, can metabolize TMA, resulting in lower TMAO,58 suggesting that differences in TMA-metabolizing gut bacteria in individuals lead to different ultimate effects, and replacement of relevant bacteria may reduce the risk from TMAO.

↥ Abundance

‐ Actinobacillus ‎Stool ‎Human [1.1]
‐ Agathobacter ‎Stool ‎Human [1.1]
‐ Akkermansia ‎Stool ‎Human [1.2]
‐ Bacteroides ‎Stool ‎Human [1.3]
‐ Bacteroidetes ‎Stool ‎Human [1.2]
‐ Barnesiellaceae ‎Stool ‎Human [1.2]
‐ Bulleidia ‎Stool ‎Human [1.2]
‐ Butyricimonas ‎Stool ‎Human [1.2]
‐ Catenibacterium ‎Stool ‎Human [1.4]
‐ Christensenellaceae ‎Stool ‎Human [1.2]
‐ Collinsella aerofaciens ‎Stool ‎Human [1.3]
‐ Collinsella ‎Stool ‎Human [1.2]
‐ Comamonas ‎Stool ‎Human [1.2]
‐ Coriobacteriaceae ‎Stool ‎Human [1.2]
‐ Desulfovibrio ‎Stool ‎Human [1.2]
‐ Enhydrobacter ‎Stool ‎Human [1.2]
‐ Enterococcus ‎Stool ‎Human [1.4]
‐ Granulicatella ‎Stool ‎Human [1.5]
‐ Haemophilus ‎Stool ‎Human [1.5]
‐ Klebsiella ‎Stool ‎Human [1.5]
‐ Lactobacillales ‎Stool ‎Human [1.6]
‐ Lactobacillus ‎Stool ‎Human [1.4]
‐ Lactococcus ‎Stool ‎Human [1.4]
‐ Leuconostocaceae ‎Stool ‎Human [1.2]
‐ Megamonas ‎Stool ‎Human [1.3]
‐ Megasphaera ‎Stool ‎Human [1.2]
‐ Odoribacter ‎Stool ‎Human [1.2]
‐ Parabacteroides distasonis ‎Stool ‎Human [1.3]
‐ Porphyromonas ‎Stool ‎Human [1.1]
‐ Prevotella stercorea ‎Stool ‎Human [1.3]
‐ Prevotella ‎Stool ‎Human [1.1]
‐ Pseudomonas ‎Stool ‎Human [1.4]
‐ Ruminococcus gnavus ‎Stool ‎Human [1.1]
‐ Shewanella ‎Stool ‎Human [1.2]
‐ Shigella ‎Stool ‎Human [1.4]
‐ Sphingobium ‎Stool ‎Human [1.2]
‐ Sphingomonadaceae ‎Stool ‎Human [1.2]
‐ Streptococcus ‎Stool ‎Human [1.5]
‐ Succiniclasticum ‎Stool ‎Human [1.1]
‐ Verrucomicrobium ‎Stool ‎Human [1.2]
‐ Weissella ‎Stool ‎Human [1.4]

↧ Abundance

‐ Acinetobacter ‎Stool ‎Human [1.1]
‐ Agrobacterium ‎Stool ‎Human [1.2]
‐ Anaerosporobacter ‎Stool ‎Human [1.1]
‐ Bacteroides plebeius ‎Stool ‎Human [1.3]
‐ Bacteroides ‎Stool ‎Human [1.6]
‐ Blautia ‎Stool ‎Human [1.2]
‐ Christensenellaceae ‎Stool ‎Human [1.1]
‐ Clostridiaceae ‎Stool ‎Human [1.3]
‐ Coprococcus ‎Stool ‎Human [1.1]
‐ Delftia ‎Stool ‎Human [1.2]
‐ Dorea ‎Stool ‎Human [1.2]
‐ Eggerthella ‎Stool ‎Human [1.2]
‐ Eisenbergiella ‎Stool ‎Human [1.1]
‐ Enterobacter ‎Stool ‎Human [1.2]
‐ Erysipelotrichaceae ‎Stool ‎Human [1.3]
‐ Eubacterium hallii ‎Stool ‎Human [1.1]
‐ Eubacterium rectale ‎Stool ‎Human [1.4]
‐ Faecalibacterium ‎Stool ‎Human [1.4]
‐ Flavonifractor ‎Stool ‎Human [1.4]
‐ Fournierella ‎Stool ‎Human [1.1]
‐ Fusicatenibacter ‎Stool ‎Human [1.1]
‐ Lachnospiraceae ‎Stool ‎Human [1.4]
‐ Lachnospira ‎Stool ‎Human [1.4]
‐ Morganella ‎Stool ‎Human [1.2]
‐ Roseburia ‎Stool ‎Human [1.4]
‐ Ruminococcaceae ‎Stool ‎Human [1.4]
‐ Ruminococcus gauvreauii ‎Stool ‎Human [1.1]
‐ Staphylococcus ‎Stool ‎Human [1.2]
‐ Streptococcus ‎Stool ‎Human [1.3]
‐ Subdoligranulum ‎Stool ‎Human [1.4]
‐ Veillonella ‎Stool ‎Human [1.1]

Related Factor

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Subclass

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Related Metabolome

‐ asymmetric dimethyl arginine (ADMA) ‎↥ ‎Blood ‎Human

References

[ ]

Common References

[1.1] Coronary artery disease is associated with an altered gut microbiome composition [2020] [PLOS ONE] [Journal] [80001293]
[1.2] Gut microbiome-based diagnostic model to predict coronary artery disease [2020] [Journal of Agricultural and Food Chemistry] [Journal] [80001414]
[1.3] The intestinal microbiota associated with cardiac valve calcification differs from that of coronary artery disease [2019] [Atherosclerosis] [Journal] [80000915]
[1.4] Dysbiosis signatures of gut microbiota in coronary artery disease [2018] [Physiological genomics] [Journal] [80000879]
[1.5] Alterations in the gut microbiome and metabolism with coronary artery disease severity_DUBLICATE [2019] [Microbiome] [Journal] [80001002]
[1.6] Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease [2017] [Heart Vessels] [Journal] [80000400]
[1.7] Long-Term Changes in Gut Microbial Metabolite Trimethylamine N-Oxide and Coronary Heart Disease Risk [2020] [Review] [Journal of the American College of Cardiology] [Journal] [80001663]
[1.8] Small molecules in the big picture of gut microbiome-host cross-talk - IMPORTANT [2022] [Review] [EBioMedicine] [Journal] [80002422]

Disease ⇒ Coronary artery disease {40000234}

Record Keys

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Notes:

References Notes

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Common References