Disease ⇒ Coronary artery disease {40000234}
Type: | Disease |
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Parent: | [ ] |
Definition: | Coronary artery disease |
Initialisation date: | [ ] |
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Other Terms: | CAD |
MedDra ID: | 10011078 |
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MedDra Level: | pt |
ICD: | [ ] |
Category: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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Shared Reference Notes
- [1.1]
- Long-term increases in TMAO were associated with higher CHD risk, and repeated assessment of TMAO over 10 years improved the identification of people with a higher risk of CHD. - Diet may modify the associations of ΔTMAO with CHD risk - [1.2] [#Atherosclerosis]
- #Bilophila, a genus of gut microbes, can metabolize #TMA, resulting in lower #TMAO, suggesting that differences in #TMA-metabolizing gut bacteria in individuals lead to different ultimate effects, and replacement of relevant bacteria may reduce the risk from #TMAO. - - #TMAO levels are also associated with #Heart failure and coronary artery disease. - #TMAO enhances the responsiveness of platelets to multiple agonists, promoting platelet hyperactivity and thus thrombosis and subsequent cardiovascular disease.
- [1.3]
- a precursor to #TMAO, #trimethyllysine (TML), alone and combined with TAMO, is involved in cardiovascular events for patients with the acute coronary syndrome. - [1.4]
- genus #Oxalobacter was positively associated with the risk of CAD.
References Notes
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