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Parabacteroides distasonis ⇒ Parabacteroides {10000226}

Record Keys


Organism:
Parabacteroides distasonis
Parent:

Details


Initialisation date:
2019-08-25

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Meta Information


Rank:
Species
Domain:
Bacteria
Zone:[  ]
Enzyme:[  ]
Function:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.20
    - P. distasonis > negatively associated with celiac disease. - P. distasonis > reduce weight gain, hyperglycemia, and liver steatosis in ob/ob and high-fat diet mice > significantly reduce the severity of intestinal inflammation in murine models of acute and chronic colitis
  • [1.9] [#Diabetes Type 1
    - The #hprt4–18 peptide produced by bacterium Parabacteroides distasonis mimics an important insulin epitope (insB:9-23). Human and mouse immune cells specific to insB:9-23 cross-react with this bacterial mimic. Further, P. distasonis can accelerate diabetes onset in a mouse model of T1D, inducing destructive immune cells and decreasing protective immune cells. - Seroconversion rates (i.e., the proportion of individuals developing two or more autoantibodies) were consistently higher in children whose microbiome harbored sequences capable of producing the #hprt4–18 peptide compared to individuals who did not harbor it.

Common References