Symptom ⇒ Fatigue ⇒ Chronic fatigue syndrome {40000199} Record Keys Type:Disease, Symptom Parent:Fatigue Definition:Chronic fatigue syndrome Details Initialisation date:2022-01-13 Other Terms:CFS Meta Information MedDra ID:10008874 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: The pathogenesis of ME/CFS, a disease characterized by fatigue, cognitive dysfunction, sleep disturbances, orthostatic intolerance, fever, irritable bowel syndrome (IBS), and lymphadenopathy, is poorly understood. - https://www.medicalnewstoday.com/articles/184802. Shared Reference Notes [1.1] [1.2] [1.3] [#Exercise training] [1.4] [#Inflamatory bowel disease, #Multiple Sclerosis] - MC/CFS > a reduction of #Faecalibacterium was also found in IBD patients with fatigue (compared to IBD patients without fatigue), , #Cancer-related fatigue (compared to #Cancer patients with low fatigue) and other autoimmune diseases such as MS and #Diabetes Type 1 . - a subset (29%) of patients had elevated levels of autoantibodies against neurotransmitter receptors, supporting the hypothesis of an autoimmune disease. - cerebral hypoperfusion leads to an anaerobic metabolism and therefore the higher lactate in cerebrospinal fluid can be explained - the microbial signature of ME/CFS and #Q-fever to be quite similar. - The abundance of Firmicutes and Actinobacteria was increase in ME/CFS patients compared to healthy controls while Bacteroidetes were reduced - MC/CFS > microbiome alterations that were consistent with an increased inflammation of the gut, namely significantly increased #Lactonifactor and #Alistipes - in particular an increase of #Alistipes and a decrease of butyrate-producer #Faecalibacterium were considered as top biomarkers with potential diagnostic value - abundance of #Bifidobacterium and #Faecalibacterium to be reduced in the affected twin compared to the non-affected one. - Decreases in #Faecalibacterium and increases in #Coprobacillus were found. - Gut abundances of #Coprobacillus, of #Eggerthella and #Blautia were best able to distinguish patients from controls. - distinct microbial pattern with decreased anti-inflammatory #Firmicutes - Several studies reported a reduction of a butyrate-producing #Bacteroides species in ME/CFS - MC/CFS > increased levels of #Ceramides, one of the three types of sphingolipids - Up to 37% of ME/CFS patients reported a past symptomatic #EBV infection - Chronic fatigue syndrome > lower anti-inflammatory species carriage and higher levels of pro-inflammatory bacterial species such as #Enterobacteriaceae were found in a 16S rRNA stool sample analysis. - Higher levels of Enterococcus spp, Streptococcus spp, lower levels of the beneficial Bifidobacteria and decreased anti-inflammatory Firmicutes have been detected. - Decreased levels of the antioxidant vitamin alpha tocopherol (#Vitamin E) found in studies with ME/CFS patients further support the potential role of increased oxidative stress. [1.5] [1.6] [1.7] [1.8] - #Faecalibacterium prausnitzii and #Eubacterium rectale, which are both recognized as abundant, health-promoting #Butyrate producers in the human gut, were reduced in ME/CFS. - deficient microbial capacity for #Butyrate synthesis. - The abundance of #Faecalibacterium prausnitzii was inversely associated with fatigue severity. [1.9] [#Irritable bowel syndrome] [#Alistipes putredinis, #Anaerotruncus colihominis, #Clostridium asparagiforme, #Coprococcus catus, #Dorea formicigenerans, #Faecalibacterium prausnitzii] - Nine bacterial species were selected to predict ME/CFS + IBS: F. prausnitzii, #Bacteroides vulgatus, A. putredinis, C. catus, #Anaerostipes caccae, D. formicigenerans, A. colihominis and C. asparagiforme. [#Irritable bowel syndrome] [#Ceramides] - patients with ME/CFS and IBS have increased plasma levels of ceramide. [#Irritable bowel syndrome] - Patients with ME/CFS and IBS also had higher plasma #Mannitol levels. - #Mannitol may increase permeability of both the gut mucosa and the blood-brain barrier resulting in trafficking of molecules such as cytokines and neurotransmitters that contribute to disease. [#Alistipes putredinis, #Anaerotruncus colihominis, #Clostridium asparagiforme, #Coprococcus catus, #Dorea formicigenerans, #Faecalibacterium prausnitzii, #Pseudoflavonifractor capillosus, #Sutterella wadsworthensis] - Eight bacterial species were found to predict ME/CFS : Coprococcus (C.) catus, Pseudoflavonifractor (P.) capillosus, Dorea (D.) formicigenerans, Faecalibacterium (F.) prausnitzii, Clostridium (C.) asparigiforme, Sutterella (S.) wadsworthensis, Alistipes (A.) putredinis and Anaerotruncus (A.) colihominis. [#Alistipes putredinis] [#Ceramides] - Decreased PC 30:0 correlated with decreased A. putredinis, , a bacterium known to produce #Sulfonolipids - unusual #Sphingolipids structurally related to ceramide. #Sphingolipids are known to maintain bacterial survival and promote stress resistance. [#Anaerotruncus colihominis] - Decreased #Betaine was associated with decreased A. colihominis. [#Bacteroides caccae, #Dorea formicigenerans] - Increased TG 54:6 A was correlated with D. formicigenerans and TG 54:8 was correlated with decreased B. caccae and D. formicigenerans. - altered plasma levels of #Choline, #Carnitine and complex lipid metabolites. - #Ceramides were associated with increased physical fatigue. [#γ-butyrobetaine] - Decreased γ-butyrobetaine correlated with increased #Faecalibacterium. - #Glutamine and #Ornithine serum levels in ME/CFS were lower, and correlated with metabolites linked to the urea cycle. [#Indole-3-lactic acid, #γ-butyrobetaine] - Indole-3-lactate and γ-butyrobetaine were also reduced in the all ME/CFS group but were not amongst the top 10 plasma biomarkers. [#Parabacteroides distasonis] - In ME/CFS without IBS, decreased #Tyrosine correlated with decreased P. distasonis. [#Irritable bowel syndrome] - ME/CFS is a multifactorial condition that is also often associated with comorbid conditions including, but not limited to, IBS and #Fibromyalgia. [#Gender] - ME/CFS is more commonly reported in females. [1.11] - short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome > reduced microbial #Butyrate biosynthesis and a reduction in plasma #Butyrate, #Bile Acids, and #Benzoate. [1.12] [#Ruminococcaceae] - genus #Paraprevotella and Ruminococcaceae_UCG_014 were positively associated with ME/CFS risk. [1.13] [#Post-acute infection syndrome] - PASC (post-acute sequelae of #Covid-19 infection) and ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) are two of the most recognized and prevalent PAIS conditions. [1.14] - #Covid-19 > The increased #Ornithine/#Citrulline ratio level in class B patients reflects abnormal metabolic activity in the urea cycle. - a similarly increased #Ornithine/#Citrulline ratio in CFS patients [#IL-17A] - Fluctuations in IL-17 have been associated with #Fatigue and #Fatigue severity in ME/CFS patients - Increased levels of #Leptin have been associated with higher #Fatigue scores in people with CFS. - daily #Fatigue severity was significantly correlated with daily serum #Leptin levels in women with CFS - patients with ME/CFS exhibited elevated blood #Lactate at rest. [#Phospholipids] - Depleted levels of lysophosphatidylcholines and phospholipid ethers, as well as depleted levels of PCs, can impede mitochondrial respiration, as has been also demonstrated in ME/CFS - Decreased levels of serum #Taurine have been observed in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). - The depleted levels observed in long COVID-19 phase could explain at least in part the fatigue, since #Taurine has multiple roles in skeletal muscle, the central nervous system, and energy metabolism. - #Taurine levels were increased in post-COVID-19 patients, suggesting hepatic injury, hepatotoxicity, or muscle damage. [1.15] [#Cognitive impairment] - #Vitamin E in improving mental health, particularly cognitive function. - certain gut microbes, like #Bacteroides and #Clostridium, are considered to possess the potential ability to metabolize #Vitamin E in the intestinal tract. - the cognitive issues observed in ME/CFS patients may be associated to specific changes in the gut microbiome and a significant reduction in #Vitamin E levels. - Noticeable decreases in other bacteria-produced metabolites, which serve as energy sources (such as #Acetate and #Isovalerate) and exhibit antimicrobial properties (such as #Lactate and #Benzoate), were observed in the ME/CFS patients as well [#Sphingolipids] - elevated levels of serum lipid profile and high #Bacteroidetes were appeared simultaneously in long-term ME/CFS patients - a significant decline in serum #Butyrate levels were found in ME/CFS patients. - decrease in #Butyrate-producing bacteria among ME/CFS patients involving genus/species like #Ruminococcus, #Faecalibacterium prausnitzii, and #Eubacterium rectale. - the abundance of these species were negatively correlated with the severity of fatigue symptoms in ME/CFS patients. [#Flagellin] - severe ME/CFS have excessive antibodies against flagellins, especially as a pathogen-associated molecular pattern (PAMP) from #Lachnospiraceae, compared to the healthy controlsReferences Notes[ ]
