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Disease ⇒ Chronic fatigue syndrome ⇒ Fatigue {40000199}

Record Keys


Type:
Disease
Definition:
Chronic fatigue syndrome
Parent:

Details


Initialisation date:
2022-01-13
Other Terms:
CFS

Meta Information


MedDra ID:
10008874
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.7] [#Exercise training
  • [1.1] [#Inflamatory bowel disease, #Multiple Sclerosis
    - MC/CFS > a reduction of #Faecalibacterium was also found in IBD patients with fatigue (compared to IBD patients without fatigue), , #Cancer-related fatigue (compared to #Cancer patients with low fatigue) and other autoimmune diseases such as MS and #Diabetes Type 1 .
  • - a subset (29%) of patients had elevated levels of autoantibodies against neurotransmitter receptors, supporting the hypothesis of an autoimmune disease. - cerebral hypoperfusion leads to an anaerobic metabolism and therefore the higher lactate in cerebrospinal fluid can be explained
  • - the microbial signature of ME/CFS and #Q-fever to be quite similar. - The abundance of Firmicutes and Actinobacteria was increase in ME/CFS patients compared to healthy controls while Bacteroidetes were reduced
  • - MC/CFS > microbiome alterations that were consistent with an increased inflammation of the gut, namely significantly increased #Lactonifactor and #Alistipes - in particular an increase of #Alistipes and a decrease of butyrate-producer #Faecalibacterium were considered as top biomarkers with potential diagnostic value - abundance of #Bifidobacterium and #Faecalibacterium to be reduced in the affected twin compared to the non-affected one. - Decreases in #Faecalibacterium and increases in #Coprobacillus were found. - Gut abundances of #Coprobacillus, of #Eggerthella and #Blautia were best able to distinguish patients from controls. - Decreases in #Faecalibacterium and increases in #Coprobacillus were found. - distinct microbial pattern with decreased anti-inflammatory #Firmicutes
  • - Several studies reported a reduction of a butyrate-producing #Bacteroides species in ME/CFS
  • - MC/CFS > increased levels of #Ceramides, one of the three types of sphingolipids
  • - Up to 37% of ME/CFS patients reported a past symptomatic #EBV infection
  • - Chronic fatigue syndrome > lower anti-inflammatory species carriage and higher levels of pro-inflammatory bacterial species such as #Enterobacteriaceae were found in a 16S rRNA stool sample analysis. - Higher levels of Enterococcus spp, Streptococcus spp, lower levels of the beneficial Bifidobacteria and decreased anti-inflammatory Firmicutes have been detected.
  • - Decreased levels of the antioxidant vitamin alpha tocopherol (#Vitamin E) found in studies with ME/CFS patients further support the potential role of increased oxidative stress.