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Disease ⇒ Chronic fatigue syndrome ⇒ Fatigue {40000199}

Record Keys


Type:
Disease
Definition:
Chronic fatigue syndrome
Parent:

Details


Initialisation date:
2022-01-13
Other Terms:
CFS

Meta Information


MedDra ID:
10008874
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.1
    - Up to 37% of ME/CFS patients reported a past symptomatic EBV infection
  • - a subset (29%) of patients had elevated levels of autoantibodies against neurotransmitter receptors, supporting the hypothesis of an autoimmune disease.
    - cerebral hypoperfusion leads to an anaerobic metabolism and therefore the higher lactate in cerebrospinal fluid can be explained
  • - Decreased levels of the antioxidant vitamin alpha tocopherol (vitamin E) found in studies with ME/CFS patients further support the potential role of increased oxidative stress.
  • - MC/CFS > increased levels of ceramides, one of the three types of sphingolipids
  • - Chronic fatigue syndrome > lower anti-inflammatory species carriage and higher levels of pro-inflammatory bacterial species such as Enterobacteriaceae were found in a 16S rRNA stool sample analysis.
    - Higher levels of Enterococcus spp, Streptococcus spp, lower levels of the beneficial Bifidobacteria and decreased anti-inflammatory Firmicutes have been detected.
  • - the microbial signature of ME/CFS and Q-fever to be quite similar.
    - The abundance of Firmicutes and Actinobacteria was increase in ME/CFS patients compared to healthy controls while Bacteroidetes were reduced
  • - MC/CFS > a reduction of Faecalibacterium was also found in IBD patients with fatigue (compared to IBD patients without fatigue), , cancer-related fatigue (compared to cancer patients with low fatigue) and other autoimmune diseases such as MS and diabetes type 1 .
  • - Several studies reported a reduction of a butyrate-producing Bacteroides species in ME/CFS
  • - MC/CFS > microbiome alterations that were consistent with an increased inflammation of the gut, namely significantly increased Lactonifactor and Alistipes
    - in particular an increase of Alistipes and a decrease of butyrate-producer Faecalibacterium were considered as top biomarkers with potential diagnostic value
    - abundance of Bifidobacterium and Faecalibacterium to be reduced in the affected twin compared to the non-affected one.
    - Decreases in Faecalibacterium and increases in Coprobacillus were found.
    - Gut abundances of Coprobacillus, of Eggerthella and Blautia were best able to distinguish patients from controls.
    - Decreases in Faecalibacterium and increases in Coprobacillus were found.
    - distinct microbial pattern with decreased anti-inflammatory Firmicutes