Flagellin {90000118} Record Keys Parent:[ ] Definition:Flagellin Queue:[ ] Details Initialisation date:2020-12-30 Specification: [ ]Source: [ ] Meta Information Structural Type:Protein Functional Type:MAMP Function:Anti-inflammatory, Anti-cancer Notes: [ ]Shared Reference Notes [1.1] - Flagellin has tumor-suppression and anti-inflammatory activities. - Cancer cells growth is substantially inhibited by microbial fecal cells from vegans and vegetarians, likely because of the higher concentration of flagellin. [1.2] [#Escherichia coli] - Flagellins of the probiotic E. coli Nissle 1917 induce beta-defensin via Toll-like receptor 5. [1.3] - Toll-like receptors (TLR) enable host innate immune system to identify pathogen-associated molecular patterns (PAMP) of microbes, such as #Lipopolysaccharide (LPS), lipoproteins or flagellin [1.4] [#Crohn’s disease, #Ulcerative Colitis] - CD, albeit not UC, is associated with increased serum levels of anti-flagellin IgG and IgA antibodies [1.5] [#Obesity] - #Oscillibacter contained genes encoding proteins with high sequence identity to lipoprotein synthesis pathway proteins responsible for synthesizing lipoprotein, a TLR2 agonist, along with flagellin synthesis and assembly machinery proteins responsible for synthesizing flagellin, a TLR5 agonist [1.6] [#mRNA vaccine] - Microbiota-derived flagellin, #Peptidoglycan, and #Lipopolysaccharide can act as natural adjuvants to vaccination, recognized by PRRs [1.7] [#Chronic fatigue syndrome] - severe ME/CFS have excessive antibodies against flagellins, especially as a pathogen-associated molecular pattern (PAMP) from #Lachnospiraceae, compared to the healthy controls [1.8] [#Inflamatory bowel disease, #Primary sclerosing cholangitis] - #Smoking increased risk of EIMs except for PSC, where there was a “protective” effect. - Multiple serologic associations were observed, including with PSC (IgG and IgA, perinuclear anti-nuclear cytoplasmic antibody; anti-#Saccharomyces cerevisiae antibodies; and anti-flagellin) and any EIM (IgG and IgA, perinuclear anti-nuclear cytoplasmic antibody; anti-#Saccharomyces cerevisiae antibodies; and anti–#Pseudomonas fluorescens-associated sequence). [1.9] [#Atopic Dermatitis] [#Roseomonas mucosa] - The production of #Sphingolipids by R. mucosa, cholinergic signaling, and flagellin expression may have contributed to therapeutic impact through induction of a TNFR2-mediated epithelial-to-mesenchymal transition. References Notes[ ]
