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Disease ⇒ Ulcerative Colitis {40000109}

Record Keys


Type:
Disease
Definition:
Ulcerative Colitis
Parent:[  ]

Details


Initialisation date:
2020-09-06
Other Terms:[  ]

Links


Meta Information


MedDra ID:
10009900
MedDra Level:
pt
ICD:[  ]
Category:
Gastroenterology, Rheumatology
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

Shared Notes


  • [1.39
    - A positive association between a “high sugar and soft drinks” pattern and UC risk
    - When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes.
  • [1.3
    - Functional analysis revealed increased fecal proteolytic and elastase activity before UC onset.
    - Elastase activity inversely correlated with the relative abundance of Adlercreutzia.
    - Elastase activity directly correlated with known proteolytic taxa, such as Bacteroides vulgatus and high elastase activity was confirmed in Bacteroides isolates from fecal samples.
    - Mice colonized with or born from pre-UC colonized dams developed higher fecal proteolytic activity and an inflammatory immune tone compared with HC colonized mice.
  • [1.40
    - Significantly higher abundances of Bifidobacterium in UC.
  • [1.41
    - The safety and tolerability of SER-287 were similar to placebo.
    - SER-287 after vancomycin was significantly more effective than placebo for induction of remission in patients with active mild to moderate UC.
  • [1.37
    - Red meat is metabolized by intestinal bacteria with production of branched-chain amino acids and toxic elements like hydrogen sulfide, nitrous compounds, amines, and ammonia that induce DNA damage of eucaryotic cells and promote colon inflammation in murine models.
    - Large epidemiological data confirmed the association between high consumption of red meat and risk of IBD development, in particular UC , where it was found to affect also the relapse risk.
  • [1.42
    - Intestinal microbiota in UC is associated with abundant small atypical N-glycans.
    - Higher level of microbiota-associated atypical N-glycans in UC than controls.
    - Atypical N-glycans act as promising biomarker candidates for pediatric UC.
  • [1.43
    - in patients suffering from ulcerative colitis (UC), P-gp expression coupled to the reduction of epithelial-derived anti-inflammatory endocannabinoids and luminal content (e.g., microbes or their metabolites) with a reduced capability to induce P-gp expression.
  • [1.45
    - Two commonly used emulsifiers, carboxymethylcellulose and polysorbate-80 > induce inflammation and metabolic changes, mediated by gut microbes.
  • [1.38
    - anti–Saccharomyces cerevisiae antibodies (ASCA) have been associated with CD.
    - ASCA detect S. cerevisiae mannan, a cell wall carbohydrate that is common to most fungi. Thus, the specificity of ASCA for Saccharomyces is not clear, since other common fungi, including Candida albicans, have abundant mannan in their cell walls.
    - Increases in both ASCA IgG and IgA are commonly observed in patients diagnosed with CD.
    - The ASCA IgA and IgG positive rate is over 50% in patients with CD and less than 5% in patients with non-IBD colitis or healthy controls.
    - In pediatric patients with CD, ASCA positivity has been associated with older children (>10 years), small bowel disease, and long-term risk of surgery.
    - In adults, ASCA has been linked to increases in disease severity, location, and age, with ASCA-positive patients more likely to have severe and complicated disease.
    - A recent study of pediatric patients in Australia noted that ASCA positivity correlated with increases and decreases in several specific bacteria, further suggesting that ASCA may be associated with specific subtypes of disease and that this may be reflected in the microbiome as well.
    - ASCA IgA was observed to be the most predictive marker of a future diagnosis of CD and was predictive as much as 5 years before diagnosis,
  • [1.33
    - microorganisms that invade the terminal ileum and colon of UC-affected individuals as the pro-inflammatory bacteria Enterohemorrhagic Escherichia coli (EHEC) and Campylobacter, which are both members of the Enterobacteriaceae family
  • - during active UC, anti-inflammatory Lactobacillus and Pediococcus acidilactici were absent in fecal samples

Common References