Microbiome & Chronic Diseases

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Enterobacteriaceae ⇒ Enterobacteriales {10000123}

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Shared Reference Notes

  • [1.74
    - Members of the Enterobacteriaceae family have a proinflammatory #Lipopolysaccharide (LPS) in the outer membrane and can exacerbate inflammation. A high relative abundance of Enterobacteriaceae is reported in inflammatory bowel diseases, in metabolic disorders like type 2 diabetes, and in immune diseases like cancers.
  • [1.75] [#Crohn’s disease] [#Condition of chronic stress
    - Stress-exposed mice > develop ileal dysbiosis, dominated by the expansion of Enterobacteriaceae. - Stress-induced glucocorticoids promote > apoptosis of CD45+CD90+ cells that normally produce #IL-22, a cytokine that is essential for the maintenance of ileal mucosal barrier integrity. - Blockade of glucocorticoid signaling or administration of recombinant #IL-22 > restores mucosal immunity, prevents ileal dysbiosis.
  • [1.70] [#Depression] [#Lactobacillaceae] [#Probiotic (Bifidobacter and Lactobacilus)
    - #Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > reduction in depressive symptoms at four and eight weeks of treatment, and #Anxiety symptoms at four weeks. > improvement in #Sleep quality. - #Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > decrease in serum interleukin-6 levels. - #Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > increased #Bifidobacteriaceae and Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota composition.
  • [1.15
    - #Chronic fatigue syndrome > lower anti-inflammatory species carriage and higher levels of pro-inflammatory bacterial species such as Enterobacteriaceae were found in a 16S rRNA stool sample analysis. - Higher levels of Enterococcus spp, Streptococcus spp, lower levels of the beneficial Bifidobacteria and decreased anti-inflammatory Firmicutes have been detected.
  • [1.35] [#Infectious diarrhea
    - The gut microbiome undergoes a dramatic taxonomic change upon diarrhea’s onset, favoring the proliferation of fast-growing facultative anaerobes. Proteobacteria (mostly Enterobacteriaceae/E. coli) and Streptococcus (mainly #Streptococcus salivarius and #Streptococcus gallolyticus) are most significantly enriched during this early phase
  • [1.76] [#Parkinson’s Disease
    - a few putative pathobionts of the family Enterobacteriaceae, #Enterococcaceae, which are assumed to possibly reduce the production of SCFA, produce endotoxins and neurotoxins that promote intestinal inflammation, are enriched in PD
  • [1.72] [#Diabetes Type 1
    - Particular bacterial protein #BefA, which is found in rodent and human gut microbes, can help restore insulin production - #BefA-related sequences uncovered homologs in a handful of bacteria of the Enterobacteriaceae family commonly found in healthy mammalian microbiomes after birth, when β cells normally undergo substantial expansion. - #BefA could induce proliferation directly in primary islet cultures from both hosts (Zebrafish and mouse). - The #BefA-containing Enterobacteriaceae bacteria are abundant colonizers of the healthy infant gut during peak neonatal β cell expansion.
  • [1.5] [#Parkinson’s Disease
    - positive correlation between Enterobacteriaceae abundance and the motor phenotype, particularly postural instability and gait alterations
  • [1.68] [#Antibiotic Therapy, #Infants treated with antibiotic
    - #Infants treated with antibiotics tend to have lower bacterial diversity as well as an increase of Enterobacteriaceae and #Enterococcus
  • [1.77
    - alkaline environment of the distant part of the small intestine promotes growth of Enterobacteriacea.

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