Disease ⇒ Acne {40000267}

Record Keys
Type:	Disease
Definition:	Acne
Parent:	[ ]

Details
Initialisation date:	[ ]
Other Terms:	[ ]

Meta Information
MedDra ID:	10000496
MedDra Level:	pt
ICD:	[ ]
Category:	[ ]
Zone:	[ ]
Mechanism:	[ ]

Notes:

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References Notes

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Shared Reference Notes

[1.3]
- Ane > increased Actinobacteria followed by Firmicutes and Proteobacteria, Cutibacterium,Staphylococcus and Corynebacterium.
- C. acnes > major species in terms of mean abundance, followed by Staphylococcus epidermidis (S. epidermidis) and Staphylococcus hominis (S. hominis);
[1.11]
- An acneic Cutibacterium acnes strain as well as its porphyrins activate NRLP3 inflammasome assembly, while this was not observed with a non-acneic strain.
[1.12]
- The men > a lower abundance of 18 microbes such as Butyricicoccus, Clostridium sensu stricto, Faecalibaculum, Bacillus, Lactococcus, Blautia, Clostridiales, Lachnospiracea incertae sedis, Ruminococcus at genus level > disordered metabolism of fatty acids.
- The female patients > increased Clostridium sensu stricto and declined Oscillibacter and Odoribacterin > dysbiosis of amino acids metabolism
[1.4]
- Lactobacilli can reduce acne lesions after daily application on the skin

↥ Abundance

‐ Aeromicrobium ‎Skin swab ‎Human [1.1]
‐ Bacteroides ‎Skin swab ‎Human [1.2]
‐ Corynebacterium ‎Skin ‎Human [1.3]
‐ Cutibacterium acnes ‎Skin ‎Human [1.3]
‐ Cutibacterium ‎Skin ‎Human [1.3]
‐ Enhydrobacter ‎Skin swab ‎Human [1.2]
‐ Enterobacteriaceae ‎Skin swab ‎Human [1.1]
‐ Enterococcus ‎Skin swab ‎Human [1.1]
‐ Faecalibacterium ‎Skin swab ‎Human [1.2]
‐ Firmicutes ‎Skin ‎Human [1.3]
‐ Klebsiella ‎Skin swab ‎Human [1.2]
‐ Lactobacilli ‎Ameliorative ‎Skin ‎Human [1.4]
‐ Mycobacterium ‎Skin swab ‎Human [1.1]
‐ Odoribacter ‎Skin swab ‎Human [1.2]
‐ Oscillospira ‎Skin swab ‎Human [1.2]
‐ Oxalobacteraceae ‎Skin swab ‎Human [1.1]
‐ Paenibacillus ‎Skin swab ‎Human [1.1]
‐ Planococcaceae ‎Skin swab ‎Human [1.1]
‐ Propionibacterium humerusii ‎Skin follicle ‎Human [1.5]
‐ Proteobacteria ‎Skin ‎Human [1.3]
‐ Rhodococcus ‎Skin swab ‎Human [1.1]
‐ Ruminococcus ‎Skin swab ‎Human [1.1]
‐ Staphylococcus epidermidis ‎Cyanoacrylate biopsy ‎Human [1.6]
‐ Staphylococcus epidermidis ‎Skin follicle ‎Human [1.5]
‐ Staphylococcus epidermidis ‎Skin ‎Human [1.3]
‐ Staphylococcus hominis ‎Skin ‎Human [1.3]
‐ Staphylococcus ‎Skin swab ‎Human [1.1]
‐ Staphylococcus ‎Skin ‎Human [1.3]

↧ Abundance

‐ Aerococcus ‎Stool ‎Human [1.7]
‐ Alkaliphilus ‎Stool ‎Human [1.7]
‐ Allobaculum ‎Stool ‎Human [1.8]
‐ Bacillus ‎Stool ‎Human [1.7]
‐ Bifidobacterium ‎Stool ‎Human [1.8]
‐ Bilophila ‎Stool ‎Human [1.7]
‐ Blautia ‎Stool ‎Human [1.7]
‐ Butyricicoccus ‎Stool ‎Human [1.7]
‐ Caloramator ‎Skin swab ‎Human [1.1]
‐ Carnobacterium ‎Stool ‎Human [1.7]
‐ Citricoccus ‎Skin swab ‎Human [1.1]
‐ Coprobacillus ‎Stool ‎Human [1.8]
‐ Cutibacterium acnes ‎Skin swab ‎Human [1.9]
‐ Enhydrobacter ‎Stool ‎Human [1.7]
‐ Fusicatenibacter ‎Stool ‎Human [1.7]
‐ Gemmiger ‎Stool ‎Human [1.7]
‐ Granulicatella ‎Stool ‎Human [1.7]
‐ Lachnospiraceae incertae sedis ‎Stool ‎Human [1.7]
‐ Lachnospira ‎Skin swab ‎Human [1.1]
‐ Lactobacillus ‎Stool ‎Human [1.8]
‐ Lactococcus ‎Stool ‎Human [1.7]
‐ Lysinibacillus ‎Stool ‎Human [1.7]
‐ Oceanobacillus ‎Stool ‎Human [1.7]
‐ Oxalobacter ‎Stool ‎Human [1.7]
‐ Paenibacillus ‎Stool ‎Human [1.7]
‐ Paraprevotella ‎Stool ‎Human [1.7]
‐ Propionibacterium acnes ‎Cyanoacrylate biopsy ‎Human [1.6]
‐ Propionibacterium acnes ‎Skin follicle ‎Human [1.5]
‐ Propionibacterium granulosum ‎Skin follicle ‎Human [1.5]
‐ Propionibacterium ‎Skin swab ‎Human [1.1]
‐ Proteobacteria ‎Skin swab ‎Human [1.10]
‐ Ruminococcus ‎Stool ‎Human [1.7]

Related Factor

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Subclass

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Related Metabolome

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References

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Common References

[1.1] Inflammatory skin is associated with changes in the skin microbiota composition on the back of severe acne patients [2019] [Experimental Dermatology] [Journal] [80001127]
[1.2] Skin microbiome differences relate to the grade of acne vulgaris [2019] [Journal of Dermatology] [Journal] [80001179]
[1.3] Rhodomyrtus tomentosa Fruit Extract and Skin Microbiota: A Focus on C. acnes Phylotypes in Acne Subjects [2020] [Research] [Cosmetics] [Journal] [80001444]
[1.4] Selective targeting of skin pathobionts and inflammation with topically applied lactobacilli [2022] [Clinical study] [Cell Reports Medicine] [Journal] [80002336]
[1.5] The balance of metagenomic elements shapes the skin microbiome in acne and health [2016] [Scientific Reports] [Journal] [80000501]
[1.6] Acne is Not Associated with Yet-Uncultured Bacteria [2008] [Journal of Clinical Microbiology] [Journal] [80000497]
[1.7] Patients with acne vulgaris have a distinct gut microbiota in comparison with healthy controls [2018] [Acta Dermato-Venereologica] [Journal] [80000937]
[1.8] Gut microbiota alterations in moderate to severe acne vulgaris patients [2018] [The Journal of Dermatology] [Journal] [80001044]
[1.9] Comparison of the skin microbiota in acne and rosacea [2020] [Experimental Dermatology] [Journal] [80001415]
[1.10] Skin microbiome and acne vulgaris: Staphylococcus, a new actor in acne [2017] [Experimental Dermatology] [Journal] [80001131]
[1.11] Porphyrins produced by acneic Cutibacterium acnes strains activate the inflammasome by inducing K+ leakage [2021] [Research] [iScience] [Journal] [80001858]
[1.12] Gender-Specific Differences in Gut Microbiota Composition Associated with Microbial Metabolites for Patients with Acne Vulgaris [2021] [Research] [Annals of Dermatology] [Journal] [80002135]
[1.13] The Human Skin Microbiome in Selected Cutaneous Diseases [2022] [Review] [Frontiers in Cellular and Infection Microbiology] [Journal] [80002353]

Disease ⇒ Acne {40000267}

Record Keys

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Notes:

References Notes

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Common References