Prevotellaceae ⇒ Paraprevotella {10000833}
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| Definition: | Paraprevotella |
| Initialisation date: | [ ] |
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| Rank: | Genus |
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| Domain: | Bacteria |
| Zone: | [ ] |
| Enzyme: | [ ] |
| Function: | Trypsin-degrading |
Notes:
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Shared Reference Notes
- [1.1] [#Behcet’s Disease] [#Butyrate, #Lactate, #Lipopolysaccharide]
- These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and Paraprevotella was observed in the BD-recipient group. - [1.2] [#Covid-19]
- Paraprevotella colonization inhibits lethal infection with murine hepatitis virus-2, a mouse coronavirus that is dependent on trypsin and trypsin-like proteases for entry into host cells - [#IG A] - Paraprevotella strains isolated from the faecal microbiome of healthy human donors are potent trypsin-degrading commensals. Mechanistically, Paraprevotella recruit trypsin to the bacterial surface through type IX secretion system-dependent polysaccharide-anchoring proteins to promote trypsin autolysis. - Paraprevotella colonization protects IgA from trypsin degradation and enhances the effectiveness of oral vaccines against Citrobacter rodentium.
- [1.3] [#Chronic fatigue syndrome] [#Ruminococcaceae]
- genus Paraprevotella and Ruminococcaceae_UCG_014 were positively associated with ME/CFS risk. - [1.4]
- #Vogt-Koyanagi-Harada syndrome (VKH) > In this uveitis syndrome, a study demonstrated heightened levels of gram-negative bacteria, eg, #Bacteroides and Paraprevotella, in patients’ stools with a decrease in #Butyrate-producing bacteria.
References Notes
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