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Disease ⇒ Cognitive impairment {40000159}

Record Keys


Type:
Disease
Definition:
Cognitive impairment
Parent:[  ]

Details


Initialisation date:
2021-09-09
Other Terms:[  ]

Meta Information


MedDra ID:[  ]
MedDra Level:[  ]
ICD:[  ]
Category:
Neurology
Zone:[  ]
Mechanism:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.2] [#Keto diet
    - Carbohydrate-restricted (ketogenic) diet potentiates CI induced by intermittent hypoxia in mice and alters the gut microbiota. - Depleting the microbiome reduces CI, whereas transplantation of the risk-associated microbiome or monocolonization with #Bilophila wadsworthia confers CI in mice fed a standard diet. - B. wadsworthia and the risk-associated microbiome disrupt hippocampal synaptic plasticity, neurogenesis, and gene expression. - The CI is associated with microbiome-dependent increases in intestinal interferon-gamma (IFNg)-producing Th1 cells. - Inhibiting Th1 cell development abrogates the adverse effects of both B. wadsworthia and environmental risk factors on CI.
  • [1.1
    - #Barnesiella was positively associated with the first principal component, DSST, and category fluency; - #Lachnospiraceae FCS020 group was positively associated with DSST. - #Sutterella was negatively associated with MoCA
  • [1.3] [#Antibiotic Therapy
    - Long-term antibiotic use in midlife is associated with small decreases in cognition assessed seven years later.

Common References