Disease ⇒ Dementia {40000512}

References Notes

Shared Reference Notes

• [1.6] 
  - Middle‐aged and old patients with vitiligo are more likely to develop dementia compared with those without vitiligo.
• [1.1] [#Herpes] 
• [1.4] [#Vitamin B12] 
  - Low B-12 not only causes central nervous system (CNS) damage by decreasing availability of methyl groups, but also allows accumulation of homocysteine, which appears to be toxic to nerve cells and blocks N-methyl-dasparate receptors. - It is also important to remember that for B-12 by itself to be functional, it needs to be converted to glutathionyl cobalamin, which requires glutathione for its synthesis. Oxidative stress can tie up glutathione and contribute further to lack of B-12 function.
• [1.2] 
  - High equol producers had >50% lower WML% than non-producers. - Equol‐producing status (non‐producers, low and high) was significantly inversely associated with WML%. (1)
• [1.5] [#High-fiber diet] 
  - Dietary fiber intake was inversely associated with risk of dementia. - The inverse association was more evident for soluble fiber intake and was confined to dementia without a history of stroke.
• [1.3] 
  - #Vitamin B12 deficiency at the brain level is associated with affective disorders, behavior changes, psychosis, cognitive impairment or decline, and dementia (including #Alzheimer’s disease and vascular dementia protection)
• [1.7] [#Non-alcoholic fatty liver disease] 
  - patients with NAFLD had higher rates of dementia and vascular dementia. - Comorbid NAFLD and either heart disease or stroke conferred a greater risk of dementia.
• [1.8] 
  - seropositivity for 4 viruses (#HSV1, #HHV6, #HHV7 and #VZV) also significantly increases the risk of dementia. - These four viruses have been described previously as neurotropic viruses.