Disease ⇒ Dementia {40000512}

References Notes

Shared Reference Notes

• [1.6] 
  - Middle‐aged and old patients with vitiligo are more likely to develop dementia compared with those without vitiligo.
• [1.5] 
  - Low B-12 not only causes central nervous system (CNS) damage by decreasing availability of methyl groups, but also allows accumulation of homocysteine, which appears to be toxic to nerve cells and blocks N-methyl-dasparate receptors.
  - It is also important to remember that for B-12 by itself to be functional, it needs to be converted to glutathionyl cobalamin, which requires glutathione for its synthesis. Oxidative stress can tie up glutathione and contribute further to lack of B-12 function.
• [1.3] 
  - High equol producers had >50% lower WML% than non-producers.
  - Equol‐producing status (non‐producers, low and high) was significantly inversely associated with WML%. (1)
• [1.2] 
  - Dietary fiber intake was inversely associated with risk of dementia.
  - The inverse association was more evident for soluble fiber intake and was confined to dementia without a history of stroke.
• [1.4] 
  - Vitamin B12 deficiency at the brain level is associated with affective disorders, behavior changes, psychosis, cognitive impairment or decline, and dementia (including Alzheimer’s disease and vascular dementia protection)