Microbiome & Chronic Diseases

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Disease ⇒ Dementia {40000512}

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References Notes

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Shared Reference Notes

  • [1.6
    - Middle‐aged and old patients with vitiligo are more likely to develop dementia compared with those without vitiligo.
  • [1.1] [#Herpes
  • [1.4] [#Vitamin B12
    - Low B-12 not only causes central nervous system (CNS) damage by decreasing availability of methyl groups, but also allows accumulation of homocysteine, which appears to be toxic to nerve cells and blocks N-methyl-dasparate receptors. - It is also important to remember that for B-12 by itself to be functional, it needs to be converted to glutathionyl cobalamin, which requires glutathione for its synthesis. Oxidative stress can tie up glutathione and contribute further to lack of B-12 function.
  • [1.2
    - High equol producers had >50% lower WML% than non-producers. - Equol‐producing status (non‐producers, low and high) was significantly inversely associated with WML%. (1)
  • [1.5] [#High-fiber diet
    - Dietary fiber intake was inversely associated with risk of dementia. - The inverse association was more evident for soluble fiber intake and was confined to dementia without a history of stroke.
  • [1.3
    - #Vitamin B12 deficiency at the brain level is associated with affective disorders, behavior changes, psychosis, cognitive impairment or decline, and dementia (including #Alzheimer’s disease and vascular dementia protection)
  • [1.7] [#Non-alcoholic fatty liver disease
    - patients with NAFLD had higher rates of dementia and vascular dementia. - Comorbid NAFLD and either heart disease or stroke conferred a greater risk of dementia.
  • [1.8
    - seropositivity for 4 viruses (#HSV1, #HHV6, #HHV7 and #VZV) also significantly increases the risk of dementia. - These four viruses have been described previously as neurotropic viruses.