Disease ⇒ Dementia {40000512}
Type: | Disease |
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Parent: | [ ] |
Definition: | Dementia |
Initialisation date: | 2020-10-23 |
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Other Terms: | ccyc |
MedDra ID: | [ ] |
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MedDra Level: | [ ] |
ICD: | [ ] |
Category: | Neurology |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.6]
- Middle‐aged and old patients with vitiligo are more likely to develop dementia compared with those without vitiligo. - [1.1] [#Herpes]
- [1.4] [#Vitamin B12]
- Low B-12 not only causes central nervous system (CNS) damage by decreasing availability of methyl groups, but also allows accumulation of homocysteine, which appears to be toxic to nerve cells and blocks N-methyl-dasparate receptors. - It is also important to remember that for B-12 by itself to be functional, it needs to be converted to glutathionyl cobalamin, which requires glutathione for its synthesis. Oxidative stress can tie up glutathione and contribute further to lack of B-12 function. - [1.2]
- High equol producers had >50% lower WML% than non-producers. - Equol‐producing status (non‐producers, low and high) was significantly inversely associated with WML%. (1) - [1.5] [#High-fiber diet]
- Dietary fiber intake was inversely associated with risk of dementia. - The inverse association was more evident for soluble fiber intake and was confined to dementia without a history of stroke. - [1.3]
- #Vitamin B12 deficiency at the brain level is associated with affective disorders, behavior changes, psychosis, cognitive impairment or decline, and dementia (including #Alzheimer’s disease and vascular dementia protection) - [1.7] [#Non-alcoholic fatty liver disease]
- patients with NAFLD had higher rates of dementia and vascular dementia. - Comorbid NAFLD and either heart disease or stroke conferred a greater risk of dementia. - [1.8]
- seropositivity for 4 viruses (#HSV1, #HHV6, #HHV7 and #VZV) also significantly increases the risk of dementia. - These four viruses have been described previously as neurotropic viruses.