Equol {60000110}

Record Keys


Parent:[  ]
Definition:
Equol
Queue:[  ]

Details


Initialisation date:
2020-10-23
Specification:

- soy ISF metabolite
- anti‐oxidant and anti‐amyloidogenic

Source:

Soy

Meta Information


Structural Type:[  ]
Functional Type:[  ]
Function:[  ]

Notes:


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Shared Reference Notes


  • [1.1] [#Multiple Sclerosis] [#Isoflavone diet
  • [1.2] [#Phytoestrogen
    - gut bacteria can metabolize isoflavones into equol, which has a higher affinity for endogenous estrogen receptors compared to dietary isoflavones. - #Isoflavone-rich diet can protect from neuroinflammatory diseases, and that protection was dependent on the ability of gut bacteria to metabolize isoflavones into equol. - mice on a diet with isoflavones showed an anti-inflammatory response compared to the mice on a diet lacking isoflavones.
  • [1.3] [#Alzheimer’s disease] [#Enterobacteriaceae bacterium
    - AD elders were also depleted in #Adlercreutzia equolifaciens, an equol-producing bacterium, which has beneficial effects in reducing experimental cutaneous inflammation in mice and the loss of which has been associated with the neurodegenerative disorder #Multiple Sclerosis.
  • [1.4
    - Humans do not have the capacity to metabolize #Phytoestrogen, but certain gut bacteria can metabolize them to produce metabolites such as S-equol (equol) from isoflavones, which shows significantly higher estrogenic activity than the original isoflavones
  • [1.5
    - #Eggerthella in humans has been shown to produce equol, a #Phytoestrogen, with estrogenic properties and binding affinity to #Estrogen receptors
  • [1.6] [#Adlercreutzia equolifaciens] [#Soybean
    - A. equolofaciens produces the nonsteroidal #Estrogen equol from isoflaven found in soybeans
  • [1.7] [#Autism
    - Several known equol producers were consistently higher in controls, including #Slackia and #Adlercreutzia equolifaciens. #Coriobacteriaceae, a family involved in lipid metabolism85 and equol production, was also depleted in #Infants with future NDs. - significant decrease in a potential equol signal in future ASD cases.
  • [#Estrogen] - Equol has been studied for anti-inflammatory effects and estrogenic activity.
  • - equol exhibits blood-brain barrier permeability capability, anti-neuroinflammatory properties, and neuroprotective effects, protecting microglia against #Lipopolysaccharide (LPS)-induced inflammation and neurotoxins.

References Notes


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