Phytoestrogen ⇒ Isoflavone {90000356} Record Keys Parent:Phytoestrogen Definition:Isoflavone Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Lipopolysaccharide] [#Isoflavone diet, #Phytoestrogen-free (phyto-free) diet] - LPS extracted from feces of mice fed an ISO diet induced increased production of anti-inflammatory cytokines from bone marrow-derived macrophages relative to fecal-LPS isolated from mice fed a PF diet. [1.2] [#Phytoestrogen] - gut bacteria can metabolize isoflavones into #Equol, which has a higher affinity for endogenous estrogen receptors compared to dietary isoflavones. - isoflavone-rich diet can protect from neuroinflammatory diseases, and that protection was dependent on the ability of gut bacteria to metabolize isoflavones into #Equol. - mice on a diet with isoflavones showed an anti-inflammatory response compared to the mice on a diet lacking isoflavones. [1.3] [#Breast cancer, #Menopause] [#Soybean] - soy isoflavone intake is associated with a modest reduction in menopausal hot flushes and decreased breast and #Prostate cancer risk. [1.4] - the change in diet from an isoflavone diet to a #Phytoestrogen-free diet significantly reduced the abundance of Bifidobacterium species, specifically #Bifidobacterium adolescentis and #Bifidobacterium longum - #IL-10 production was significantly higher in the mice kept on an isoflavone diet suggesting an immunoregulatory effect. [#Lipopolysaccharide] - the LPS derived from the feces of mice kept on the #Phytoestrogen-free diet induced significantly higher levels of TNF-α, IL-1β, #IL-6, #IL-12/23, and CXCL1 compared to the LPS derived from feces of mice kept on the isoflavone-diet. - mice on an isoflavone diet showed a lower inflammatory response as measured by antigen-specific CD4 T-cell proliferation, pro-inflammatory cytokine production, and increased levels of sera metabolites linked with an anti-inflammatory nature such as polyunsaturated fatty acids [#Multiple Sclerosis] - mice on a diet with isoflavones (a type of #Phytoestrogen) are protected from EAE> depended on the presence of gut microbiota as antibiotic depletion of microbiota abrogated the disease protective effect, and supplementation with #Phytoestrogen metabolizing bacteria restored disease protective function.References Notes[ ]
