MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine
Sign in

Disease ⇒ Prostate cancer ⇒ Cancer {40000176}

Record Keys


Type:
Disease
Definition:
Prostate cancer
Parent:

Details


Initialisation date:
2020-09-01
Other Terms:[  ]

Links


Meta Information


MedDra ID:
10060862
MedDra Level:
pt
ICD:[  ]
Category:
Gastroenterology, Urology, Oncology
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


[  ]

Shared Reference Notes


  • [1.4
    - Propionibacterium acnes is the most predominant bacteria found and its presence is significantly associated with prostate tissue inflammation. - Escherichia and also Propionibacterium acnes has the highest relative abundance.
  • [1.5
    - Androgen deprivation (Abiraterone acetate ) therapy depletes androgen-utilizing Corynebacterium in prostate cancer patients and that oral AA further enriches for the health-associated commensal, Akkermansia muciniphila. - Functional inferencing elucidates a coinciding increase in bacterial biosynthesis of vitamin K2 (an inhibitor of androgen dependent and independent tumor growth)
  • [1.6] [#Androgen deprivation therapy (ADT)
    - unique microbial signature in patients undergoing oral androgen deprivation therapy (ADT) as compared with prostate cancer patients not on ADT. - Patients undergoing ADT also had enrichment of bacterial metabolic pathways promoting androgen synthesis. Together, these studies have identified a unique GU microbiome and linked both the GU microbiome and unique gut microbial signatures with prostate cancer and prostate cancer treatments.
  • [1.3] [#High-fat diet, #Western-style diet
    - HFD promoted inflammatory PCa growth. - The expression of Hdc, the gene responsible for #Histamine biosynthesis, and #Histamine levels were upregulated in large prostate tumors of HFD-fed mice, and the number of mast cells increased around the tumor foci. - HFD intake induced gut dysbiosis, resulting in the elevation of serum #Lipopolysaccharide (LPS) levels. Intraperitoneal injection of LPS increased Hdc expression in PCa.
  • [1.2
    -The antibacterial and antitumor defensin (HBD1) showed decreased levels in prostate cancer patients, while others (HBD2 and 3) were considerably increased. - Abundance of #Staphylococcus, #Corynebacterium and #Oxyphotobacteria genera was significantly higher, the abundance of #Faecalibacterium and #Bacteroides genera were significantly lower in prostate tumor samples compared to non-tumor samples. - #Bacteroides, Parabacteroides and #Faecalibacterium abundance gradually decreased with the combined increase in HBD2 and HBD3. - Higher #Corynebacterium and #Staphylococcus abundances were measured together with higher HBD2 and HBD3 urinary levels.