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Disease ⇒ Prostate cancer ⇒ Cancer {40000176}

Record Keys


Type:
Disease
Definition:
Prostate cancer
Parent:

Details


Initialisation date:
2020-09-01
Other Terms:[  ]

Links


Meta Information


MedDra ID:
10060862
MedDra Level:
pt
ICD:[  ]
Category:
Gastroenterology, Urology, Oncology
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


[  ]

Shared Reference Notes


  • [1.3
    - Propionibacterium acnes is the most predominant bacteria found and its presence is significantly associated with prostate tissue inflammation.
    - Escherichia and also Propionibacterium acnes has the highest relative abundance.
  • [1.4
    - Androgen deprivation (Abiraterone acetate ) therapy depletes androgen-utilizing Corynebacterium in prostate cancer patients and that oral AA further enriches for the health-associated commensal, Akkermansia muciniphila.
    - Functional inferencing elucidates a coinciding increase in bacterial biosynthesis of vitamin K2 (an inhibitor of androgen dependent and independent tumor growth)
  • [1.5
    - unique microbial signature in patients undergoing oral androgen deprivation therapy (ADT) as compared with prostate cancer patients not on ADT.
    - Patients undergoing ADT also had enrichment of bacterial metabolic pathways promoting androgen synthesis. Together, these studies have identified a unique GU microbiome and linked both the GU microbiome and unique gut microbial signatures with prostate cancer and prostate cancer treatments.
  • [1.2
    - HFD promoted inflammatory PCa growth.
    - The expression of Hdc, the gene responsible for histamine biosynthesis, and histamine levels were upregulated in large prostate tumors of HFD-fed mice, and the number of mast cells increased around the tumor foci.
    - HFD intake induced gut dysbiosis, resulting in the elevation of serum lipopolysaccharide (LPS) levels. Intraperitoneal injection of LPS increased Hdc expression in PCa.

Common References