Microbiome & Chronic Diseases

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Faecalibacterium prausnitzii ⇒ Faecalibacterium {10000130}

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Faecalibacterium prausnitzii


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Enzyme:[  ]
Anti fibrosis, Anti-inflammatory, Anti-cancer


- Faecalibacterium prausnitzii was named after the German bacteriologist Otto Prausnitz and was first described in 2002. - - - Since it does not survive contact with oxygen, it went undetected for a long time when trying to cultivate it. It is now well known, but many mechanisms are not yet fully understood.
- It became famous for the formation of short-chain fatty acids such as butyrate and acetate.
- In fact, F. prausnitzii is the strongest butyrate generator that we have in us.
- butyrat as an extremely important fatty acid has shown multiple anti-inflammatory effects by inhibiting pro-inflammatory substances such as IL-8 and helping the immune system to differentiate from regulatory T cells. It also serves as an important source of energy for the cells of the intestinal wall.
- The bacterium is also used diagnostically as an indicator for the intestinal barrier. If the concentration is low and additional inflammation values ​​such as zonulin and calprotectin are high, one speaks of leaky gut, the permeable intestinal barrier.
- A low F. prausnitzii concentration is associated with more inflammation in the intestine. This behavior was first linked to Crohn’s disease in 2008. The stronger the symptoms of the disease, the lower the frequency of F. prausnitzii and butyrate. One study showed that even in Crohn’s patients in remission (symptoms decreased, but no cure), the number of F. prausnitzii was reduced.
- A deficiency of F. prausnitzii can also lead to immune regulation disorders or metabolic diseases.
- F. prausnitzii can be supplied well with the fiber inulin which can be found in chicory, artichokes and onions.
- Within the gut microbiome, it is particularly well networked with the species A. muciniphila. itssubstrates are an important food source for F. prausnitzii. An assessment of one species is therefore always accompanied by an assessment of the other.
- F. prausnitziiis the largest producer of butyrate and the largest consumer of acetate and is the most important species inhabiting the intestine. Its depletion along with the reduction of Bifidobacterium (which is more reduced in patients with kidney stones) leads to a reduction in the intestinal butyrate levels, which thence leads to a functional instability in the gastrointestinal tract and urothelium thereby resulting in an inflammatory pattern. (1)
- F. prausnitziiis which is often diminished in patients with Crohn’s disease, appear to exert many of their protective effects through the release of a fatty acid called butyrate.
- F. prausnitziiis modulates immune system.
- F. prausnitziiis modulates is the indicator for leaky gut.

References Notes

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Shared Reference Notes

  • [1.74
    - Certain Faecalibacterium prausnitzii strains possess some ability to utilise apple pectin. - F. prausnitzii strains in common with E. eligens can utilise the galacturonide oligosaccharides DP4 and DP5 derived from sugar beet pectin.
  • [1.69] [#Cancer] [#Plant-based diet
    - High levels of plant dietary fibers in the gut resulted in proliferation of Faecalibacterium prausnitzii with anti-inflammatory and anti-tumor effects.
  • [1.77] [#Non-industrialized envirounment
    - Non-industrialized countries > increased #Prevotella copri, Faecalibacterium prausnitzii and #Prevotella stercorea in #Infants.
  • [#Prevotella stercorea] [#Aging] - P. stercorea or F. prausnitzii > develop steadily with age
  • [1.37
    - Members of the genera #Oscillospira and #Coprococcus in the cecum, as well as Faecalibacterium prausnitzii and members of the genus #Bacteroides in the ileum > negatively correlated with #Fibrosis.
  • [1.78
    - #Butyrate plays a role in regulating immune response via expansion of Treg cell populations, which is suggestive of a role for SCFA in ameliorating pro-inflammatory responses of immune cells to antigenic stimuli. - Faecalibacterium prausnitzii, help maintain homeostasis through production of SCFAs (#Butyrate) and modulation of downstream inflammatory pathways through potential induction of a tolerogenic cytokine profile (e.g., low secretion of proinflammatory and elevated secretion of anti-inflammatory cytokines)
  • [1.16
    - The most prominent butyrogenic bacteria groups are Faecalibacterium prausnitzii, #Butyrivibriocrossotus and #Roseburia intestinalis which several studies have reported the depletion of these bacteria in atherosclerosis
  • [1.76] [#Bacteroides vulgatus, #Butyricicoccus pullicaecorum
    - the tested consortium was composed of four butyrate producers (Faecalibacterium prausnitzii, Butyricicocccus pullicaecorum, #Roseburia inulinivorans, and #Anaerostipes caccae) and five propionate producers (#Roseburia inulinivorans, #Akkermansia muciniphila, Phocaeicola vulgatus, #Veillonella parvula, and #Blautia obeum)
  • [1.39] [#Butyrate
    - Faecalibacterium prausnitzii, member of Clostridium leptum subgroup, representing more than 5% of the total gut microbiota in healthy humans, is one of the most abundant #Butyric acid producing bacteria of the gut microbiome. It favorably modulates intestinal immune system, oxidative stress and colonocyte metabolism. - it reduces intestinal inflammatory processes with inhibition of the pro-inflammatory interleukin 8.
  • [1.72] [#Depression] [#Dark chocolate
    - #Blautia obeum levels were significantly elevated and Faecalibacterium prausnitzii levels were reduced in DC85 compared to CON (P<.05). - Mood states were measured using the Positive and Negative Affect Schedule (PANAS) - the observed changes in negative affect scores were negatively correlated with diversity and relative abundance of #Blautia obeum.
  • [1.13] [#Ulcerative Colitis] [#Primary bile acids, #Secondary bile acids
    - colonic CD displayed a disease-severity-related association with #Bacteroides vulgatus. - Compared to colonic CD, ileal CD profiles displayed increased primary and secondary bile acid levels and concomitant shifts in taxa with noted sensitivities such as Faecalibacterium prausnitzii or affinities for bile acid-rich environments, including #Gammaproteobacteria and #Blautia sp.
  • [1.73
    - GutAlive maintained extremely #Oxygen sensitive (EOS) populations that were lost in conventional stool containers, and thus viability of species such as as #Akkermansia muciniphila, Faecalibacterium prausnitzii and a novel member of the #Clostridiales order was kept.

Common References