Microbiome & Chronic Diseases

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Disease ⇒ Obesity {40000167}

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Gastroenterology, Endocrinology, Metabolomics
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a higher amount of Firmicutes in a sample is associated with obesity development, while higher Bacteroidetes is associated with weight loss.

References Notes

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Shared Reference Notes

  • [1.44] [#Antibiotic Therapy
    - Early antibiotic exposure in animal models has shown that reductions in the population size of specific microbiota, such as Lactobacillus, Allobaculum, Rikenellaceae, and Candidatus Arthromitus, are related to subsequent adiposity.
  • [1.19
    - The probiotic strain #Hafnia alvei HA4597® (HA), which produces the satietogenic peptide ClpB mimicking the effect of alpha-MSH, reduced weight gain and adiposity in rodent models of obesity.
  • [1.45
    - Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers.
  • [#Saturated fatty acids (SFAs)] - Saturated fatty acids (SFAs) were negatively associated with the genus #Intestinimonas, a biomarker of the overweight/obese group.
  • [1.48
    - The presence of a dysbiotic microbiome > subsequent increases in gut permeability to bacteria-derived pathogens, including LPS and ethanol. - LPS, gut peptides, SCFAs and lactate > Microbiota-brain-gut axis > Gut afferent neuron > key signaling molecules involved in gut-brain communication and host metabolism.
  • - #Bacteroidetes > prevalence is lower in obese people > low-calorie diet > proportion increasealong with weight loss based on a low-calorie diet .
  • [#Short Chain Fatty Acid] - SCFAs > activation of their receptors GPR43 and GPR41 > inhibits lipolysis > adipocyte differentiation.
  • [1.50
    - Low levels of #Bacteroidetes phylum > associate with obesity and #High fasting glucose > increases following the “good” diet and decreases following the “bad” diet
  • - Low levels of #Alistipes putredinis > obesity > increased following the “good” diet
  • - Low levels of #Bifidobacterium adolescentis > associated with greater weight loss > generally decrease in RA following the “good” diet and increase following the “bad” diet
  • [1.51] [#Diabetes Type 2] [#Gender, #Resistant starch
    - gut microbiota, especially #Faecalibacterium, Predict postprandial glucose response (PPGR) after eating potatoes.
  • [1.52] [#Metabolic syndrome] [#Fecal Microbiota Transplantation, #High-fiber diet
  • [1.53
    - Maternal consumption of #Sweeteners > altered cecal microbial composition and metabolism of #Propionate/#Lactate in their offspring. - Offspring daily body weight gain, liver weight and body fat > correlate positively to the relative abundance of key microbes and enzymes involved in #Succinate/#Propionate production while negatively correlated to that of #Lactose degradation and #Lactate production. - The altered #Propionate/#Lactate production in the cecum of weanlings from aspartame and stevia consuming dams implicates an altered ratio of dietary carbohydrate digestion, mainly #Lactose, in the small intestine vs. microbial fermentation in the large intestine.
  • [1.42
    -Severe obesity is associated with an absolute deficiency in bacterial #Biotin producers and transporters, whose abundances correlate with host metabolic and inflammatory phenotypes
  • [1.41] [#Serotonin (5-hydroxytryptamine)] [#Antibiotic Therapy
    - Gut Dysbiosis > increase hypothalamic microRNA-204 (miR-204), a microRNA > reduce SIRT1 and BDNF > decrease in the sympathetic nerve activity > increase the browning of WAT > Obesity
  • [1.54
    - In 214 humans, they found the average blood levels of #Delta-valerobetaine was 40 percent higher for people with a BMI greater than 30 compared to those with lower BMIs. - #Delta-valerobetaine contributes to obesity and hepatic steatosis by modulating mitochondrial fatty acid oxidation and increasing lipid storage in the adipose tissue and liver.
  • [1.55] [#Diabetes Type 2, #Obesity (Diet induced)] [#Yogurt consumption
    - yogurt intake impacts the hepatic metabolome, notably maintaining the levels of branched chain hydroxy acids (BCHA) which correlate with improved metabolic parameters
  • [1.56] [#Short Chain Fatty Acid
    - SCFAs have been reported to have potential to enhance intestinal gluconeogenesis, with hepatic glucose production declining and energy-spending increasing.2 Furthermore, SCFAs are capable of facilitating peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) secretion, which can promote satiety and increase peripheral glucose catabolism
  • - increased levels of #Succinate (an important metabolite of glucose metabolism) in plasma and feces of obese patients and a positive correlation between #Succinate levels and body weight.
  • [#Urolithin A] - UA has also been shown to prevent hereditary or HFD-induced obesity by increasing energy expenditure mainly through promoting thermogenesis of brown adipose tissue (BAT) and browning of white adipose tissue (WAT)
  • [#δ-valerobetaine TMAVA] - δ-valerobetaine (TMAVA), a trimethylamine N-oxide (TMAO) structural analogue, was indicated to be a diet-dependent obesogen that could exacerbate obesity in mice induced by the western diet
  • [1.57] [#Diabetes Type 2, #Obesity (Diet induced)
    - In healthy human subjects #Akkermansia muciniphila was associated to low body weight, low body fat proportion, reduced adipose tissue inflammation and reduced insulin resistance.
  • [#Lactobacillus animalis] - several bacteria such as: #Methanobrevibacter smithii, #Bifidobacterium spp., #Bifidobacterium animalis, #Escherichia coli, #Akkermansia muciniphila, #Anaerotruncus colihominis and bacteria of the Bacteroidetes strain have the capability to reduce the production of high-calorie substances and therefore also influence the caloric intake. A relatively low frequency of these bacteria correlates with increased body weight, as we have also observed.
  • [1.58] [#Obesity (Diet induced)
  • [1.28] [#Whole grains
    - Harboring high levels of #Prevotella at baseline resulted in increased weight loss in individuals with excess body weight who consumed whole grain-rich diets
  • [1.59] [#Obesity (Diet induced)] [#Akkermansia muciniphila
  • [1.60] [#Celiac Disease
  • [1.61] [#Allergy, #Diabetes Type 1, #Infantile eczema
    #Infants treated with antibiotic > The early use of this treatment has been associated with higher risks of allergic diseases, eczema , and obesity, and type 1 diabetes
  • [#Allergy] - #Exposure to pets increases the abundance of Ruminococcus and Oscillospira species, which may protect against allergic disorders and obesity in children
  • [1.62] [#Short Chain Fatty Acid
    - SCFAs activate mucosal G protein-coupled receptors in the gut so they contribute to the regulation of secretion of incretin hormones such as glucagon like peptide-1, peptide YY and leptin.
  • [1.40
    - #Delta-valerobetaine production by the gut microbiome reduces cellular carnitine and mitochondrial long-chain acyl-coenzyme A (acyl-CoA); consequently, this obesogenic metabolite prevents mitochondrial fatty acid oxidation and leads to diet-dependent obesity.
  • [1.63] [#Prediabetes] [#High-fat diet
    - microbiota protects against development of obesity, #Metabolic syndrome, and pre-diabetic phenotypes by inducing commensal-specific Th17 cells. - High-fat, high-#Sugar diet promoted metabolic disease by depleting Th17-inducing microbes, and recovery of commensal Th17 cells restored protection. - Diet-induced loss of protective Th17 cells was mediated by the presence of #Sugar. - Eliminating #Sugar from high-fat diets protected mice from obesity and #Metabolic syndrome in a manner dependent on commensal-specific Th17 cells. - #Sugar and ILC3 promoted outgrowth of #Faecalibaculum rodentium that displaced Th17-inducing microbiota.
  • [1.64] [#Diabetes Type 2] [#Blautia wexlerae] [#Oral administration of Blautia wexlerae
    - Blautia genus, especially B. wexlerae, as a commensal bacterium that is inversely correlated with obesity and type 2 diabetes mellitus. - Oral administration of B. wexlerae to mice induce metabolic changes and anti-inflammatory effects that decrease both high-fat diet–induced obesity and diabetes. - The beneficial effects of B. wexlerae are correlated with unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and L-ornithine and carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate, with simultaneous modification of the gut bacterial composition. - S-adenosylmethionine, acetylcholine, and L-ornithine have anti-inflammatory properties and modify aspects of host metabolism, such as lipid metabolism, indicating that these compounds are potential effector metabolites for controlling obesity and diabetes.
  • [1.65
    - Supplementation of #Bifidobacterium pseudolongum has fat-reducing effect on obese mice. - #Bifidobacterium pseudolongum treatment significantly decreased the plasma triglycerides and gross energy intake. - #Bifidobacterium pseudolongum improved the intestinal environment, increased the colonization of beneficial bacteria, and changed the composition and structure of gut microbiota.

Common References