Disease ⇒ Dyslipidemia {40000533} Record Keys Type:Disease Parent:[ ] Definition:Dyslipidemia Details Initialisation date:2022-01-12 Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#CVD, #Postprandial lipidemia, #Diabetes Type 2] [#Berberine] [#Probiotic] - Prob+BBR superior to BBR or Prob alone in improving postprandial total cholesterol (pTC) and low-density lipoprotein cholesterol (pLDLc) levels with decrement of multiple species of postprandial lipidomic metabolites after 3 months follow-up. - This effect was linked to the changes of fecal #Bifidobacterium breve level responding to BBR alone or Prob+BBR treatment. - Four fadD genes encoding long-chain acyl-CoA synthetase > identified in the genome of this B. breve strain, and transcriptionally activated by BBR. - The activation of fadD by BBR could enhance FFA import and mobilization in B. breve and diliminish the intraluminal lipids for absorption to mediate the effect of Prob+BBR on PL. [1.2] [#Metabolic associated fatty liver disease] [#Fibroblast growth factor 21] [#Resistant starch] - The serum level of FGF21 was found to be significantly reduced after the 4-month RS intervention. - FGF21 > alleviation of dyslipidemia and NAFLD. - circulating FGF21 is paradoxically elevated in individuals with NAFLD > FGF21 resistance in analogy to obesity-associated insulin and leptin resistance. - aberrant FGF21 signaling has been suggested as a key pathological step in the development and progression of NAFLD. [1.3] [#Short Chain Fatty Acid] - Consumption of green banana biomass seems to exert beneficial effects on intestinal function and potential effects on #Obesity, dyslipidemia, and diabetes. These effects may be related to increased fecal short-chain fatty acid concentrations as a result of type 3 #Resistant Starch present in biomass. [1.4] [#Short Chain Fatty Acid] [#Prebiotic, #Probiotic] - A 12-week multi-species synbiotic supplementation in patients with dyslipidemia resulted in significant increases in fecal SCFAs including #Acetate, #Butyrate, #Propionate, and #Valerate in the intervention group.References Notes[ ]
