Disease ⇒ Gastric carcinoma {40000342}

Shared Reference Notes

• [1.1] 
  - #Aquabacterium, #Streptococcus and #Lachnospiraceae > predict gastric cancer. - patients with low levels of #Streptococcus and #Lachnospiraceae > more likely to live with gastric cancer without it getting worse. - Patient > more bacterial genes involved in the breakdown of #D-galacturonate > play a key role in the development of gastric cancer
• [1.2] 
  - #Candida and #Alternaria were enriched in GC, while Saitozyma and Thermomyces were GC-depleted
• [#Cytomegalovirus] - HCMV was found to be higher in GC tissue than adjacent normal tissues and was implicated as being associated with carcinogenesis and possibly lymphatic metastasis of GC.
• - #EBV integrates its DNA into the host, expresses latent protein, and then impairs methylation of DNA via miRNA under the action of the latent protein, resulting in #EBV-positive gastric cancer.
• [1.3] [#Helicobacter pylori] 
  - The progression of #Chronic gastritis toward gastric carcinoma has been characterized by the reduction in the Helicobacter genus, overgrowth of opportunistic bacteria, increased apoptosis, necrosis, and collagen production, changes in the cytoskeleton and polarity of the gastric epithelium, and gradual suppression of gastric acidity.
• [#Peptic ulcer] [#Helicobacter pylori] - H. pylori has a substantial association with chronic gastritis, gastric ulcer, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma.
• [1.4] 
  - The bile acid receptor TGR5 is overexpressed in gastric adenocarcinoma, and #Bile Acids can increase cell proliferation via TGR5 signaling.
• [1.5] 
  - For instance, #Peptostreptococcus stomatis engages in gastrointestinal cancers and is of significant centralities in the gastric carcinoma (GC) ecological network, which mediates the pathogenesis of precancerous gastric atrophy (GA) and #Intestinal metaplasia (IM)
• [1.6] 
  - The oral taxa #Neisseria, #Prevotella, and #Veillonella had centralities in tumors with intestinal and mixed phenotypes and were associated with MUC13 overexpression, highlighting their role as potential drivers in MUC13 signaling in GC.

References Notes