Microbiome & Chronic Diseases

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Neisseriaceae ⇒ Neisseria {10000757}

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Shared Reference Notes

  • [1.1
    - Coexisting #Hypertension and #Periodontal disease > increased Neisseria and #Solobacterium genera
  • [1.2
    - Microbiota composition and predicted function in #Celiac Disease was largely determined by intestinal location. In the duodenum, but not stool, there was higher abundance of #Escherichia coli, #prevotella salivae, and Neisseria. - Neisseria, an opportunistic pathogen previously found to be increased in patients with active #Celiac Disease, was associated with more severe enteropathy. - Expression of microbial glutamate carboxypeptidase was lower in the duodenum of celiac patients, and its decrease in mice also correlated with impaired gluten degradation, suggesting a potential candidate for future therapeutic development.
  • [1.3] [#Diabetes Type 1, #Diabetes Type 2
    - Compared to the levels in non-diabetic individuals, diabetes patients exhibited a higher abundance of Neisseria, TM7, #Gemella, #Eikenella, #Selenomonas, #Actinomyces, #Capnocytophaga, #Fusobacterium, #Aggregatibacter, #Veillonella, and #Streptococcus genera and a lower abundance of Filifactor, Synergistetes, Tannerella, Eubacterium, Porphyromonas, and Treponema genera
  • [1.4] [#Gastric carcinoma
    - The oral taxa Neisseria, #Prevotella, and #Veillonella had centralities in tumors with intestinal and mixed phenotypes and were associated with MUC13 overexpression, highlighting their role as potential drivers in MUC13 signaling in GC.
  • [1.5
    -The genera Neisseria, #Prevotella and #Haemophilus are also highly abundant, with a prevalence of 6–29%, depending on the site.
  • [1.6] [#Rothia aeria, #Rothia dentocariosa, #Rothia mucilaginosa
    Inhaled Glucocorticoid > Dysbisis > presence of typical oral #Bacteria (Neisseria spp. and #Streptococcus spp.), alongside with the potentially pathogenic #Actinomyces spp. and three different #Rothia species, identified simultaneously: R. aeria, R. dentocariosa, and R. mucilaginosa. > - Although quadrupled dose of corticoids was discontinued and ulcer healing was observed, the patients required topical therapy for maintained xerostomia. - Progressive systemic autoimmunity (seronegative Sjögren’s syndrome with major organ involvement) was observed later.
  • [1.7] [#Cancer] [#Alcohol Consumption
    - Genus Neisseria had extremely high ADH activity and produced significant amounts of #Acetaldehyde in vitro. - Neisseria’s ability to produce #Acetaldehyde was more than 100-fold higher than that produced by #Streptococcus sp., Stomatococcus sp., or #Moraxella sp. - Neisseria can be a regional source of carcinogenic #Acetaldehyde and may thus play an essential role in alcohol-related carcinogenesis in humans

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