Microbiome & Chronic Diseases

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Disease ⇒ Periodontal disease {40000225}

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Periodontal disease


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Shared Reference Notes

  • [1.1
    -#Streptococcus salivarius K12 and M18 prevented immune activation induced by periodontal disease pathogens.
  • [1.2
    - Coexisting #Hypertension and periodontal disease > increased #Neisseria and #Solobacterium genera
  • [1.3
    - #Saccharibacteria species > reduce inflammation and consequential bone loss by modulating host bacterial pathogenicity in a mouse ligature-induced periodontitis model.
  • [1.4] [#Chronic periodontitis
    - #Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (#Leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to #Rheumatoid Arthritis. - Aa has been proposed as a link between periodontitis and autoimmunity in #Rheumatoid Arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs).
  • [1.5] [#Secretory calcium-binding phosphoprotein proline-g
    - Secretory calcium-binding phosphoprotein proline-glutamine rich 1 (SCPPPQ1), a protein normally produced by the gingival epithelium to mediate its attachment to teeth, was suggested to be bactericidal. - Incubation of #Porphyromonas gingivalis, a major periodontopathogen, with the full-length protein resulted in decrease in bacterial number, formation of aggregates and membrane disruptions.
  • [1.6] [#Multiple Sclerosis] [#Porphyromonas gingivalis] [#Lipopolysaccharide
    - in periodontitis-diseased tissues, P. gingivalis was present, but not much LPS was evident in tissues. - these bacterial lipids accumulate in structures in blood vessels that can lead to thickening or blockages called atheromas. - in the blood of MS patients, and they found that the bacterial lipid levels were lower in MS patients, a very surprising result. They expected, if anything, that patients with the autoimmune disease would have more lipid present.
  • [1.7
    - Transplantation of periopathogenic microbiota from the SP patients altered the caecal microbiota and induced low-grade intestinal inflammation in mice. - The abundance of #Porphyromonadaceae and #Fusobacterium, which are co-pathogens in periodontitis and intestinal inflammation was significantly enriched in the gut of the C-SP group. - Interestingly, #Porphyromonadaceae was also enriched in the salivary samples from the humans, revealing the close relationship between the salivary and gut microbiota.
  • [1.8
  • [1.9] [#Alzheimer’s disease
    - In patients with AD, oral bacteria were detected in brain tissues, and increased levels of pro-inflammatory cytokines were also detected.
  • - Periodontal disease is more common in individuals with #Rheumatoid Arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs). - Citrullination is the conversion of the amino acid arginine into the non-proteinogenic amino acid citrulline. - Patients with RA and periodontal disease experienced repeated oral bacteremias associated with transcriptional signatures of specific monocytes, recently identified in inflamed RA synovia and blood of those with RA flares. - The oral bacteria observed transiently in blood were broadly citrullinated in the mouth, and their in situ citrullinated epitopes were targeted by extensively somatically hypermutated ACPA B Cells encoded by RA blood plasmablasts.
  • [1.11] [#Chronic periodontitis] [#Fusobacterium nucleatum
    - Chronic oral infection establishes ectopic oral F. nucleatum colonization in the intestine and significantly induces systemic humoral IgG and IgM antibody responses
  • [#Fusobacterium nucleatum] - successful periodontitis treatment reduces stool F. nucleatum levels

References Notes

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