Disease ⇒ Periodontal disease {40000225}
Type: | Disease |
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Definition: | Periodontal disease |
Parent: | [ ] |
Initialisation date: | [ ] |
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Other Terms: | [ ] |
MedDra ID: | 10034536 |
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MedDra Level: | pt |
ICD: | [ ] |
Category: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.6]
-Streptococcus salivarius K12 and M18 prevented immune activation induced by periodontal disease pathogens. - [1.7]
- Coexisting hypertension and periodontal disease > increased Neisseria and Solobacterium genera - [1.5]
- Saccharibacteria species > reduce inflammation and consequential bone loss by modulating host bacterial pathogenicity in a mouse ligature-induced periodontitis model. - [1.8]
- Secretory calcium-binding phosphoprotein proline-glutamine rich 1 (SCPPPQ1), a protein normally produced by the gingival epithelium to mediate its attachment to teeth, was suggested to be bactericidal.
- Incubation of Porphyromonas gingivalis, a major periodontopathogen, with the full-length protein resulted in decrease in bacterial number, formation of aggregates and membrane disruptions. - [1.9]
- in periodontitis-diseased tissues, P. gingivalis was present, but not much LPS was evident in tissues.
- these bacterial lipids accumulate in structures in blood vessels that can lead to thickening or blockages called atheromas.
- in the blood of MS patients, and they found that the bacterial lipid levels were lower in MS patients, a very surprising result. They expected, if anything, that patients with the autoimmune disease would have more lipid present. - [1.10]
- Transplantation of periopathogenic microbiota from the SP patients altered the caecal microbiota and induced low-grade intestinal inflammation in mice.
- The abundance of Porphyromonadaceae and Fusobacterium, which are co-pathogens in periodontitis and intestinal inflammation was significantly enriched in the gut of the C-SP group.
- Interestingly, Porphyromonadaceae was also enriched in the salivary samples from the humans, revealing the close relationship between the salivary and gut microbiota.