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Disease ⇒ Periodontal disease {40000225}

Record Keys


Type:
Disease
Definition:
Periodontal disease
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:[  ]

Meta Information


MedDra ID:
10034536
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.6
    -#Streptococcus salivarius K12 and M18 prevented immune activation induced by periodontal disease pathogens.
  • [1.7
    - Coexisting #Hypertension and periodontal disease > increased #Neisseria and #Solobacterium genera
  • [1.5
    - #Saccharibacteria species > reduce inflammation and consequential bone loss by modulating host bacterial pathogenicity in a mouse ligature-induced periodontitis model.
  • [1.8] [#Secretory calcium-binding phosphoprotein proline-g
    - Secretory calcium-binding phosphoprotein proline-glutamine rich 1 (SCPPPQ1), a protein normally produced by the gingival epithelium to mediate its attachment to teeth, was suggested to be bactericidal. - Incubation of #Porphyromonas gingivalis, a major periodontopathogen, with the full-length protein resulted in decrease in bacterial number, formation of aggregates and membrane disruptions.
  • [1.9] [#Multiple Sclerosis] [#Porphyromonas gingivalis] [#Lipopolysaccharide
    - in periodontitis-diseased tissues, P. gingivalis was present, but not much LPS was evident in tissues. - these bacterial lipids accumulate in structures in blood vessels that can lead to thickening or blockages called atheromas. - in the blood of MS patients, and they found that the bacterial lipid levels were lower in MS patients, a very surprising result. They expected, if anything, that patients with the autoimmune disease would have more lipid present.
  • [1.10
    - Transplantation of periopathogenic microbiota from the SP patients altered the caecal microbiota and induced low-grade intestinal inflammation in mice. - The abundance of #Porphyromonadaceae and #Fusobacterium, which are co-pathogens in periodontitis and intestinal inflammation was significantly enriched in the gut of the C-SP group. - Interestingly, #Porphyromonadaceae was also enriched in the salivary samples from the humans, revealing the close relationship between the salivary and gut microbiota.

Common References