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Disease ⇒ Reactive arthritis {40000346}

Record Keys


Type:
Disease
Parent:[  ]
Definition:
Reactive arthritis

Details


Initialisation date:[  ]
Other Terms:
RA

Meta Information


MedDra ID:
10003267
MedDra Level:
llt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


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Shared Reference Notes


  • [1.1] [#Inflamatory bowel disease
    - HLA-B27 spondyloarthropathies (SpA) > #Ankylosing spondylitis, reactive arthritis, #Psoriatic Arthritis, #Juvenile idiopathic arthritis, inflammatory bowel disease, #Acute anterior uveitis, and undifferentiated SpA > segmented filamentous bacteria (SFB) have been illustrated to be a common culprit in initiating an arthritogenic reaction. - The Th17 response, induced in the mesenteric lymph nodes by dendritic cells, in such patients specifically targets SFB, resulting in a breach in the mucosal barrier. - This is thought to result from cross-reactivity between HLA-B27 and pathogenic surface antigens. - Other enteric gram-negative pathogens, which mimic HLA-B27, associated with SpA and uveitis include #Shigella, #Chlamydia and #Yersinia

References Notes


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