Disease ⇒ Reactive arthritis {40000346}
Type: | Disease |
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Parent: | [ ] |
Definition: | Reactive arthritis |
Initialisation date: | [ ] |
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Other Terms: | RA |
MedDra ID: | 10003267 |
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MedDra Level: | llt |
ICD: | [ ] |
Category: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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Shared Reference Notes
- [1.1] [#Inflamatory bowel disease]
- HLA-B27 spondyloarthropathies (SpA) > #Ankylosing spondylitis, reactive arthritis, #Psoriatic Arthritis, #Juvenile idiopathic arthritis, inflammatory bowel disease, #Acute anterior uveitis, and undifferentiated SpA > segmented filamentous bacteria (SFB) have been illustrated to be a common culprit in initiating an arthritogenic reaction. - The Th17 response, induced in the mesenteric lymph nodes by dendritic cells, in such patients specifically targets SFB, resulting in a breach in the mucosal barrier. - This is thought to result from cross-reactivity between HLA-B27 and pathogenic surface antigens. - Other enteric gram-negative pathogens, which mimic HLA-B27, associated with SpA and uveitis include #Shigella, #Chlamydia and #Yersinia
References Notes
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