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Disease ⇒ Hypertension {40000141}

Record Keys


Type:
Disease
Definition:
Hypertension
Parent:[  ]

Details


Initialisation date:
2020-09-06
Other Terms:
HTN , HT, high blood pressure (HBP)

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Meta Information


MedDra ID:
10020772
MedDra Level:
pt
ICD:[  ]
Category:
Cardiovascular
Zone:[  ]
Mechanism:[  ]

Notes:


- Higher levels of the genus Ruminococcus > increased risk of high blood pressure. (3)
- Along with a reduction in Bacteroidetes members, hypertensive individuals were indeed mainly characterized by increased proportions of Lactobacillus and Akkermansia while decreased relative abundances of well-known butyrate-producing commensals, including Roseburia and Faecalibacterium within the Lachnospiraceae and Ruminococcaceae families.

References Notes


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Shared Reference Notes


  • [1.2
    - Along with a reduction in Bacteroidetes members, hypertensive individuals were indeed mainly characterized by increased proportions of Lactobacillus and Akkermansia while decreased relative abundances of well-known butyrate-producing commensals, including Roseburia and Faecalibacterium within the Lachnospiraceae and Ruminococcaceae families.
  • [1.8
    - Sodium reduction > increased all 8 SCFAs > significant increases in 2-methylbutyrate, butyrate, hexanoate, isobutyrate, and valerate. - Increased SCFAs > decreased blood pressure and improved arterial compliance > significant sex differences of SCFAs in response to sodium reduction. - Sodium reduction only in Female > significant increases in butyrate, hexanoate, isobutyrate, isovalerate, and valerate. - In females > changes in isobutyrate, isovalerate, and 2-methylbutyrate > inversely associated with reduced blood pressures. - Increased valerate > associated with decreased carotid-femoral pulse wave velocity.
  • [1.9
    - Elevated putative succinate-producing bacteria and acetate-producing bacteria > respectively, lower and higher mean arterial pressure in mouse - Prevotella and Klebsiella > overrepresented in individuals with pHTN or HTN.
  • [1.10] [#Akkermansia muciniphila] [#Vitamin B1 (Thiamin)
    - A. muciniphila > vitamin B1 productio > may influence blood pressure.
  • [1.11] [#Short Chain Fatty Acid
    - Olf78 >The last receptor for SCFAs > observed in the olfactory bulb, enteroendocrine cells, the kidney, blood vessels, skeletal muscle, and heart. - Acetate and propionate, but not butyrate > stimulate Olf78 > induces an increase in blood pressure via renin secretion .
  • [1.12
    - A 5-day fast followed by a modified Dietary Approach to Stop Hypertension diet reduces systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared to a modified Dietary Approach to Stop Hypertension diet alone. - #Fasting alters > gut microbiome > impacting bacterial taxa and gene modules associated with short-chain fatty acid production.
  • - #Propionate treatment in mice > antihypertensive effect.
  • [1.14] [#Parabacteroides] [#Flavonoid] [#Flavonoid-Rich Foods
  • - #Prevotella copri > thrives in a pro-inflammatory environment. - The superoxide reductase and phosphoadenosine phosphosulphate reductase encoded by #Prevotella copri > may favor the development of inflammation. - Colonization with #Prevotella copri > enhances body weight loss and exacerbates epithelial inflammation in colitis mouse model.
  • - 9,10-dichloro-octadecanoic acid (stearic acid) > positive association > microflora including Klebsiella, #Prevotella, and Enterbacter > all overrepresented in HTN. - In HTN > microbial richness and diversity > decreased with #Prevotella-dominated gut enterotype. - Faecalibacterium, Oscillibacter, Roseburia, Bifidobacterium, Coprococcus, and Butyrivibrio > declined in pHTN and HTN patients. - The enterotype dominated by #Prevotella > increased in pHTN and HTN populations. - Stearic acid, an important metabolite in HTN, is positively linked to #Prevotella. - #Prevotella > triggering the inflammatory response > HTN.
  • [1.7
    - Nitrate-rich supplements > stimulate nitrate reduction by the oral microbiota > resulting in a lowering of blood pressure.
  • [1.17
    - Coexisting hypertension and #Periodontal disease > increased #Neisseria and #Solobacterium genera
  • [1.6
    - Abundance of #Blautia and #Odoribacter showed a negative correlation with high SBP
  • [1.18
    - Microbial α diversity indexes (Observed OTUs, Chao1 Index, and Shannon Index) did not differ according to BP categories at baseline (P>0.05, all; Figure S1). Comparison of bacteria relative abundances according to BP categories at baseline are given in Table 2 and Table S3. Significant differences (uncorrected P<0.05) were observed for 47 (of 245 total) species‐level OTUs across baseline BP categories (Table 2). Of these, 25 were enriched in elevated BP and prevalent hypertension, and 22 were enriched in normal BP. The greatest mean differences in bacteria were between normal BP and prevalent hypertension. For those enriched in prevalent hypertension, the 5 largest mean differences were for Treponema socranskii (CLR mean difference [d]=0.79; P<0.001), Oribacterium oral taxon 078 (d=0.76; P<0.001), Veillonellaceae G1 sp. oral taxon 155 (d=0.74; P=0.001), Prevotella oralis (d=0.69; P=0.003), and Veillonellaceae G1 sp. oral taxon 150 (d=0.66; P=0.01). For those enriched in normal BP, the 5 largest mean differences were for TM7 G1 sp. oral taxon 869 (d=0.77; P<0.001), Leptotrichia sp. oral taxon 212 (d=0.76; P=0.001), Rothia aeria (d=0.73; P=0.001), Leptotrichia sp. oral taxon 225 (d=0.67; P=0.01), and Streptococcus sanguinis (d=0.64; P<0.001). Following correction for multiple comparisons, 12 (of 47) bacteria remained statistically significant (corrected P<0.05). Results for all 245 species‐level OTUs included in the analysis are given Table - salivary nitrite concentrations were enriched by nitrate‐reducing oral microbiota, ultimately leading to increased formation of NO,34 a potent vasodilator - (Corynebacterium durum) differed significantly with baseline BP categories (higher in normotensive women), and one species (Neisseria subflava) was significantly inversely associated with incident hypertension.
  • [1.19
    - Blood pressure > increased #Acetate, #Butyrate, and #Propionate
  • [#High salt diet] - Salt consumption decreased #Lactobacillus abundance, which was linked to increased T helper 17 cell numbers in murine small intestinal lamina propria lymphocytes and human peripheral blood lymphocytes, as well as higher blood pressure. - a high-salt diet reduced #Lactobacillus abundance, increased proinflammatory gene expression, and exacerbated #Colitis in two separate disease models
  • [1.21
    - Bacteroidetes (Odoribacter and Alistipes genera) > often contribute to the overall butyrogenic pool. - SCFA-producing bacteria > may affect blood pressure by direct effects of SCFA on vasodilation or through plasminogen activator inhibitor-1 (PAI-1)

Common References