Oscillospiraceae ⇒ Oscillibacter {10000281} Record Keys Parent:Oscillospiraceae Definition:Oscillibacter Details Initialisation date:2020-10-04 Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - Increased relative abundances of fecal Oscillibacter and #Alistipes > causally linked to decreased #Triglyceride concentration. [1.2] [#Diabetes Type 2] [#Coprococcus etes] - There are 36 different strains of #Butyrate-producing bacteria, and five of them are associated with increased insulin sensitivity: #Coprococcus etes, Oscillibacter sp. CAG 241, #Alistipes finegoldi and #Faecalibacterium prausnitzii. - The genus #Coprococcus was associated with higher insulin sensitivity and disposition index and a lower rate of dysglycemia. [1.3] [#Bipolar disorder, #Major depressive disorder, #Schizophrenia] - MDD was often characterized by higher #Alistipes and #Parabacteroides and lower #Prevotella; BD by higher #Bifidobacterium and Oscillibacter; and SZ by higher #Prevotella and lower #Bacteroides, #Haemophilus, and #Streptococcus [#Bipolar disorder] [#kynurenic acid] - there is an inverse relationship between Oscillibacter (a genera increased in patients with BD) and the levels of #Tryptophan and KYNA. [1.4] [#Aging] - the loss of #Lactobacillus and #Faecalibacterium, as well as the abundance of Oscillibacter and #Alistipes genera along with the #Eubacteriaceae family is linked to #Frailty in elderly people. [1.5] [#Obesity] [#Physical activity] - In overweight > high PA duration > participants had a lower abundance of the Oscillibacter genus. [1.6] - #Lachnospira pectinoschiza, #Eubacterium eligans, and likely the uncharacterized Oscillibacter are #Butyrate producers [1.7] [#High Fat Diet] - Oscillibacter spp. were correlated with decreased colonic epithelial integrity in the context of a high-fat diet in mice [1.8] [#Obesity] - Oscillibacter contained genes encoding proteins with high sequence identity to lipoprotein synthesis pathway proteins responsible for synthesizing lipoprotein, a TLR2 agonist, along with #Flagellin synthesis and assembly machinery proteins responsible for synthesizing #Flagellin, a TLR5 agonistReferences Notes[ ]
