Disease ⇒ Hypercholesterolaemia {40000312}

Record Keys


Type:
Disease
Parent:[  ]
Definition:
Hypercholesterolaemia

Details


Initialisation date:[  ]
Other Terms:[  ]

Meta Information


MedDra ID:
10020603
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


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Shared Reference Notes


  • [1.1
    - coprostanol-forming microbes : ismA genes > cholesterol dehydrogenases : Cholestrol > contribute to coprostanol formation: significantly lower fecal cholesterol levels and lower serum total cholesterol with effects comparable to those attributed to variations in lipid homeostasis genes.
  • [1.2
    - High levels of #Isobutyric acid could be one such biomarker for hypercholesterolemia.
  • [1.3] [#Beta-glucan] [#Oat
    - Oats could be considered a functional food because of the presence of β-glucan, a soluble fiber shown to reduce #Cholesterol
  • - #Bile Acids can be deconjugated by certain microbiota, which inhibits their reabsorption > elevation of bile acid synthesis inliver > reducing of Blood #Cholesterol
  • [1.4] [#CVD] [#Enterococcus faecium, #Lactobacillus paracasei] [#Cholesterol
    - E. faecium strain 132 and L. paracasei strain 201 may alleviate hypercholesterolemia in rats
  • - #Enterococcus faecium strain 132 and #Lactobacillus paracasei strain 201 reduced liver inflammation, improved the lipid profile by regulating the gene expression related to #Cholesterol metabolism and reduced fat accumulation.
  • [1.5
    - #Lactobacillus and #Bifidobacterium, which act as beneficial bacteria in the gut, contribute to the prevention of diseases such as hypercholesterolemia

References Notes


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