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Disease ⇒ CVD {40000183}

Record Keys


Type:
Disease
Definition:
CVD
Parent:[  ]

Details


Initialisation date:
2020-09-28
Other Terms:
Cardiovascular Disease

Meta Information


MedDra ID:[  ]
MedDra Level:[  ]
ICD:[  ]
Category:
Cardiovascular
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


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Shared Reference Notes


  • [1.4
    - Choline > Elevated plasma levels of the gut microbe-dependent metabolite #TMAO > predict incident risk for CVD development independent of traditional risk factors.
  • [1.1] [#γ-butyrobetaine
    - #Meat-based diet > L-carnitine > Gut microbial transformation >intermediate γ-butyrobetaine (γBB) > trimethylamine (TMA) > TMAO - Plasma γBB levels in individuals > strongly associated with incident CVD event risks. - #Emergencia timonensis > metabolize γBB into TMA > complete the carnitine → γBB → TMA transformation > elevate TMAO levels > enhance thrombosis
  • [1.5] [#Fish consumption
    - Fish > rich in preformed #TMAO > greatest impact on circulating #TMAO concentrations; however, fish intake is associated with decreased risk of cardiovascular disease
  • [1.6] [#Diabetes Type 2, #Dyslipidemia, #Postprandial lipidemia] [#Berberine] [#Probiotic
    - Prob+BBR superior to BBR or Prob alone in improving postprandial total cholesterol (pTC) and low-density lipoprotein cholesterol (pLDLc) levels with decrement of multiple species of postprandial lipidomic metabolites after 3 months follow-up. - This effect was linked to the changes of fecal #Bifidobacterium breve level responding to BBR alone or Prob+BBR treatment. - Four fadD genes encoding long-chain acyl-CoA synthetase > identified in the genome of this B. breve strain, and transcriptionally activated by BBR. - The activation of fadD by BBR could enhance FFA import and mobilization in B. breve and diliminish the intraluminal lipids for absorption to mediate the effect of Prob+BBR on PL.
  • [1.7] [#Reduction of salt intake
  • [1.8] [#Heart failure, #Hearth attack
  • [1.2
    - #Indoxyl sulfate could promote vascular inflammation.
  • [1.9] [#Bile Acids, #Primary bile acids, #Secondary bile acids, #Short Chain Fatty Acid, #TMA, #TMAO

Common References