Microbiome & Chronic Diseases

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Bacteroidetes ⇒ Negibacteria {10000142}

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- The main producers of butyrate

Shared Notes

  • [1.38
    - Bacteroidetes trigger intestinal immune cells to release interferons. Interferons are key factors that ramp up the body’s response to viruses and help eliminate cells that are infected.
    - Bacteroidetes have a specific molecule on their cell surface called a glycolipid that causes intestinal immune cells to release antiviral interferons.
  • [1.42
    - Obesity alters the balance of Firmicutes in non-obese individuals to Bacteroidetes phyla in obese ones.
  • [1.43
    - Gut-targeted delayed-release NA but not NAM produced a significant increase in the abundance of Bacteroidetes.
    - In the absence of systemic side effects, these favorable microbiome changes induced by microencapsulated delayed-release NA were associated with an improvement of biomarkers for systemic insulin sensitivity and metabolic inflammation.
  • [1.44
    - Bacteroidetes has a substrate preference for certain fats.
  • [1.45
    - Bacteroidetes > prevalence is lower in obese people > low-calorie diet > proportion increasealong with weight loss based on a low-calorie diet .
  • [1.46
    - Low levels of Bacteroidetes phylum > associate with obesity and high fasting glucose > increases following the “good” diet and decreases following the “bad” diet
  • [1.47
    - Protein powder consumption > decrease in Lachnospiraceae, Roseburia, Blautia, Synergistales, Coprococcus, Lactobacillales, Bacilli, Bifidobacterium longum and Firmicutes.
    - Protein powder consumption > higher abundance of Bacteroidetes.
  • [1.48
    - Decrease in Bacteroidetes and Alloprevotella and increase in Proteobacteria, Verrucomicrobia, Akkermansia, and Desulfovibrio > improve short-term memory ability and cognitive level of AD mice
  • [1.41
    - High ceramide levels > associated with insulin resistance, hypercholesterolemia, liver steatosis, and the formation of lipid rafts.
    - Some classes of ceramides in the blood increase the risk for late-onset Alzheimer’s disease, as they are neurotoxic and induce apoptosis .
    - Bacteroidetes phylum can synthesize sphingolipids > human epithelial cells > Ceramides
  • [1.49
    - Intraperitoneal administration of L654 over 7 weeks to HFD-fed Ldlr−/− mice resulted in hypocholesterolemic effects and significantly attenuated the progression of atherosclerosis.
    - L654 and other bacterial glycine lipids in feces, liver, and serum were markedly reduced alongside changes in Bacteroidetes relative abundance in HFD-fed mice.
  • [1.50
    - Actinobacteria were found to be increased, whereas Bacteroidetes were decreased in relation to other phyla, and some studies suggested decreased microbial diversity in MDD patients

Common References