Disease ⇒ Behcet’s Disease {40000121}

Record Keys

Parent:[  ]
Behcet’s Disease


Initialisation date:
Other Terms:
BD, Behçet Disease


Meta Information

MedDra ID:
MedDra Level:
ICD:[  ]
Rheumatology, Immunology
Zone:[  ]
Gut Inflammation, Leaky gut, Reduced SCFA


- A significant decrease of butyrate production in patients was demonstrated (1)
- Lack of butyrate (antiinflamatory) > Lack of Mucin

Shared Reference Notes

  • [1.1] [#Butyrate
  • [1.2] [#Butyrate, #Lactate, #Lipopolysaccharide
    - These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and #Paraprevotella was observed in the BD-recipient group.
  • - a similar effect was observed by the administration of #Eubacterium rectale (a kind of #Butyrate-producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of #Colchicine, which is used to treat BD patients.
  • [1.3
    - Depleted #Dorea, #Blautia, #Coprococcus, #Erysipelotrichaceae and #Lachnospiraceae as well as enriched #Bilophila and #Stenotrophomonas were identified in BU patients.
  • - A peptide antigen (SteTDR) encoded by BU specifically enriched #Stenotrophomonas was identified to share homology with IRBP161-180. - Addition of the SteTDR peptide to the classical IRBP immunization protocol exacerbated EAU severity.
  • [1.4
    - Behcet’s disease > Stool samples were enriched with #Parabacteroides, sulphate-reducing bacteria #Bilophila and #Desulfovibrionaceae species. In addition, it was also noted that #Butyrate-producing bacteria #Clostridium and methanogens were reduced. - Transplantation of BD faeces in mice illustrated remarkable results in which gut integrity was breached due to decreased expression of tight junctions, with the subsequent effects of experimental uveitis.
  • [1.5
    - decrease in the proportion of #Butyrivibrio species in the intestinal tracts of patients with Behcet’s disease.

References Notes

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Common References

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