Disease ⇒ Behcet’s Disease {40000121}

Record Keys
Type:	Disease
Parent:	[ ]
Definition:	Behcet’s Disease

Details
Initialisation date:	2020-09-06
Other Terms:	BD, Behçet Disease

Links
Wickipedia Merck Manual

Meta Information
MedDra ID:	10004213
MedDra Level:	pt
ICD:	[ ]
Category:	Rheumatology, Immunology
Zone:	[ ]
Mechanism:	Gut Inflammation, Leaky gut, Reduced SCFA

Notes:

- A significant decrease of butyrate production in patients was demonstrated (1)
- Lack of butyrate (antiinflamatory) > Lack of Mucin

Shared Reference Notes

[1.1] [#Butyrate]
[1.2] [#Butyrate, #Lactate, #Lipopolysaccharide]
- These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and #Paraprevotella was observed in the BD-recipient group.
- a similar effect was observed by the administration of #Eubacterium rectale (a kind of #Butyrate-producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of #Colchicine, which is used to treat BD patients.
[1.3]
- Depleted #Dorea, #Blautia, #Coprococcus, #Erysipelotrichaceae and #Lachnospiraceae as well as enriched #Bilophila and #Stenotrophomonas were identified in BU patients.
- A peptide antigen (SteTDR) encoded by BU specifically enriched #Stenotrophomonas was identified to share homology with IRBP161-180. - Addition of the SteTDR peptide to the classical IRBP immunization protocol exacerbated EAU severity.
[1.4]
- Behcet’s disease > Stool samples were enriched with #Parabacteroides, sulphate-reducing bacteria #Bilophila and #Desulfovibrionaceae species. In addition, it was also noted that #Butyrate-producing bacteria #Clostridium and methanogens were reduced. - Transplantation of BD faeces in mice illustrated remarkable results in which gut integrity was breached due to decreased expression of tight junctions, with the subsequent effects of experimental uveitis.

References Notes

[ ]

↥ Microbiota

‐ Acidaminococcus Stool Human [1.5]
‐ Bacteroides eggerthii Stool Human [1.6]
‐ Bifidobacterium bifidum Stool Human [1.5]
‐ Bifidobacterium dentium Saliva Human [1.7]
‐ Bifidobacterium Stool Human [1.8]
‐ Bilophila Stool Human [1.2, 1.6]
‐ Collinsella aerofaciens Stool Human [1.6]
‐ Eggerthella lenta Stool Human [1.5]
‐ Eggerthella Stool Human [1.8]
‐ Eubacterium rectale Ameliorative Gut Lumen Human [1.2]
‐ Fusobacterium Stool Human [1.6]
‐ Haemophilus parainfluenzae Saliva Human [1.9]
‐ Lactobacillus iners Stool Human [1.5]
‐ Lactobacillus mucosae Stool Human [1.5]
‐ Lactobacillus salivarius Stool Human [1.5]
‐ Mitsuokella multacida Stool Human [1.6]
‐ Oscillibacter Stool Human [1.6]
‐ Parabacteroides Stool Human [1.6]
‐ Paraprevotella clara Stool Human [1.6]
‐ Paraprevotella Stool Human [1.2, 1.6]
‐ Prevotella histicola Saliva Human [1.7]
‐ Rothia Tissue biopsie Human [1.7]
‐ Streptococcus Stool Human [1.5]

↧ Microbiota

‐ Acidiphilium Stool Human [1.6]
‐ Actinomyces graevenitzii Saliva Human [1.9]
‐ Alistipes Stool Human [1.6]
‐ Alloprevotella Saliva Human [1.9]
‐ Anaerotruncus Stool Human [1.6]
‐ Atopobium parvulum Saliva Human [1.9]
‐ Bacteroidetes Saliva Human [1.9]
‐ Bulleidia moorei Saliva Human [1.9]
‐ Butyrivibrio Stool Human [1.5]
‐ Campylobacter concisus Saliva Human [1.7]
‐ Campylobacter Saliva Human [1.9]
‐ Clostridiales Saliva Human [1.9]
‐ Clostridium Stool Human [1.6]
‐ Coprococcus Stool Human [1.6]
‐ Dialister invisus Stool Human [1.6]
‐ Eubacterium Stool Human [1.6]
‐ Filifactor Stool Human [1.5]
‐ Fusobacterium mortiferum Stool Human [1.6]
‐ Fusobacterium periodonticum Saliva Human [1.7]
‐ Gemella sanguinis Saliva Human [1.7]
‐ Lachnoanaerobaculum orale Saliva Human [1.9]
‐ Lachnospiraceae Saliva Human [1.9]
‐ Leptotrichia Saliva Human [1.9]
‐ Megamonas hypermegale Stool Human [1.5]
‐ Megamonas Stool Human [1.8]
‐ Megasphaera elsdenii Stool Human [1.6]
‐ Methanoculleus Stool Human [1.6]
‐ Methanomethylophilus Stool Human [1.6]
‐ Neisseria Saliva Human [1.7]
‐ Neisseria Tissue biopsie Human [1.7]
‐ Oribacterium sinus Saliva Human [1.7]
‐ Prevotella copri Causal? Gut Lumen Human
‐ Prevotella enoeca Saliva Human [1.9]
‐ Prevotella pallens Saliva Human [1.9]
‐ Prevotella Stool Human [1.8]
‐ Pyramidobacter piscolens Stool Human [1.6]
‐ Roseburia Causal? Gut Lumen Human
‐ Roseburia Stool Human [1.10]
‐ Selenomonas Saliva Human [1.9]
‐ Streptococcus infantis Stool Human [1.5]
‐ Subdoligranulum Causal? Gut Lumen Human
‐ Subdoligranulum Stool Human [1.10]
‐ TM7 Saliva Human [1.9]
‐ Veillonella Saliva Human [1.9]
‐ Veillonella Tissue biopsie Human [1.7]

Intervention by Microbiota

[ ]

↥ Metabolome

‐ Butyrate Ameliorative [1.1, 1.2]
‐ Lactate Stool Human [1.2]

↧ Metabolome

‐ Butyric acid Causal? Stool Human [1.2]
‐ Sulfate Stool Human [1.2]

Intervention by Metabolome

[ ]

Related Factor

[ ]

Subclass

[ ]

References

(1) [Link REMOVED] [2015] Behçet’s syndrome patients exhibit specific microbiome signature.

Author: MetaBiom
Identifier: 40000121
URL: https://www.metabiom.org/disease/20/behcets-disease
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome [2021] [Research] [Circulation Research] [Journal] [80002329]
[1.2] Findings on the Relationship Between Intestinal Microbiome and Vasculitis [2022] [Frontiers in Cellular and Infection Microbiology] [Journal] [80002464]
[1.3] Gut microbial signatures and their functions in Behcet’s uveitis and Vogt-Koyanagi-Harada disease [2023] [Journal of Autoimmunity] [Journal] [80002936]
[1.4] The Link Between Gastrointestinal Microbiome and Ocular Disorders [2023] [80003145]
[1.5] Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients witch Behcet’s disease [2019] [Clinical Rheumatology] [Journal] [80001223]
[1.6] A metagenomic study of the gut microbiome in Behcet’s disease [2018] [Microbiome] [Journal] [80000793]
[1.7] The oral mucosal and salivary microbial community of Behcet’s syndrome and recurrent aphthous stomatitis [2015] [Journal of Oral Microbiology] [Journal] [80000423]
[1.8] Bifidobacteria abundance-featured gut microbiota compositional change in patients with Behcet’s Disease [2016] [PLOS ONE] [Journal] [80000346]
[1.9] Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behcet’s disease [2016] [Clinical Immunology] [Journal] [80000770]
[1.10] Behçet’s syndrome patients exhibit specific microbiome signature [2015] [Autoimmunity Reviews] [Journal] [80000507]

Disease ⇒ Behcet’s Disease {40000121}

Record Keys

Details

Links

Meta Information

Notes:

Shared Reference Notes

References Notes

Common References