Disease ⇒ Behcet’s Disease {40000121}
Type: | Disease |
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Parent: | [ ] |
Definition: | Behcet’s Disease |
Initialisation date: | 2020-09-06 |
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Other Terms: | BD, Behçet Disease |
MedDra ID: | 10004213 |
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MedDra Level: | pt |
ICD: | [ ] |
Category: | Rheumatology, Immunology |
Zone: | [ ] |
Mechanism: | Gut Inflammation, Leaky gut, Reduced SCFA |
Notes:
- A significant decrease of butyrate production in patients was demonstrated (1)
- Lack of butyrate (antiinflamatory) > Lack of Mucin
References Notes
[ ]
Shared Reference Notes
- [1.8] [#Butyrate]
- [1.5] [#Butyrate, #Lactate]
- These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and #Paraprevotella was observed in the BD-recipient group. - - a similar effect was observed by the administration of #Eubacterium rectale (a kind of #Butyrate-producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of colchicine, which is used to treat BD patients.