Disease ⇒ Behcet’s Disease {40000121}

Record Keys
Type:	Disease
Parent:	[ ]
Definition:	Behcet’s Disease

Details
Initialisation date:	2020-09-06
Other Terms:	BD, Behçet Disease

Links
Wickipedia Merck Manual

Meta Information
MedDra ID:	10004213
MedDra Level:	pt
ICD:	[ ]
Category:	Rheumatology, Immunology
Zone:	[ ]
Mechanism:	Gut Inflammation, Leaky gut, Reduced SCFA

Notes:

- A significant decrease of butyrate production in patients was demonstrated (1)
- Lack of butyrate (antiinflamatory) > Lack of Mucin

References Notes

[ ]

Shared Reference Notes

[1.8] [#Butyrate]
[1.5] [#Butyrate, #Lactate]
- These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and #Paraprevotella was observed in the BD-recipient group.
- a similar effect was observed by the administration of #Eubacterium rectale (a kind of #Butyrate-producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of colchicine, which is used to treat BD patients.

↥ Microbiota

‐ Acidaminococcus Stool Human [1.1]
‐ Bacteroides eggerthii Stool Human [1.2]
‐ Bifidobacterium bifidum Stool Human [1.1]
‐ Bifidobacterium dentium Saliva Human [1.3]
‐ Bifidobacterium Stool Human [1.4]
‐ Bilophila Stool Human [1.2, 1.5]
‐ Collinsella aerofaciens Stool Human [1.2]
‐ Eggerthella lenta Stool Human [1.1]
‐ Eggerthella Stool Human [1.4]
‐ Eubacterium rectale Ameliorative Gut Lumen Human [1.5]
‐ Fusobacterium Stool Human [1.2]
‐ Haemophilus parainfluenzae Saliva Human [1.6]
‐ Lactobacillus iners Stool Human [1.1]
‐ Lactobacillus mucosae Stool Human [1.1]
‐ Lactobacillus salivarius Stool Human [1.1]
‐ Mitsuokella multacida Stool Human [1.2]
‐ Oscillibacter Stool Human [1.2]
‐ Parabacteroides Stool Human [1.2]
‐ Paraprevotella clara Stool Human [1.2]
‐ Paraprevotella Stool Human [1.2, 1.5]
‐ Prevotella histicola Saliva Human [1.3]
‐ Rothia Tissue biopsie Human [1.3]
‐ Streptococcus Stool Human [1.1]

↧ Microbiota

‐ Acidiphilium Stool Human [1.2]
‐ Actinomyces graevenitzii Saliva Human [1.6]
‐ Alistipes Stool Human [1.2]
‐ Alloprevotella Saliva Human [1.6]
‐ Anaerotruncus Stool Human [1.2]
‐ Atopobium parvulum Saliva Human [1.6]
‐ Bacteroidetes Saliva Human [1.6]
‐ Bulleidia moorei Saliva Human [1.6]
‐ Butyrivibrio Stool Human [1.1]
‐ Campylobacter concisus Saliva Human [1.3]
‐ Campylobacter Saliva Human [1.6]
‐ Clostridiales Saliva Human [1.6]
‐ Clostridium Stool Human [1.2]
‐ Coprococcus Stool Human [1.2]
‐ Dialister invisus Stool Human [1.2]
‐ Eubacterium Stool Human [1.2]
‐ Filifactor Stool Human [1.1]
‐ Fusobacterium mortiferum Stool Human [1.2]
‐ Fusobacterium periodonticum Saliva Human [1.3]
‐ Gemella sanguinis Saliva Human [1.3]
‐ Lachnoanaerobaculum orale Saliva Human [1.6]
‐ Lachnospiraceae Saliva Human [1.6]
‐ Leptotrichia Saliva Human [1.6]
‐ Megamonas hypermegale Stool Human [1.1]
‐ Megamonas Stool Human [1.4]
‐ Megasphaera elsdenii Stool Human [1.2]
‐ Methanoculleus Stool Human [1.2]
‐ Methanomethylophilus Stool Human [1.2]
‐ Neisseria Saliva Human [1.3]
‐ Neisseria Tissue biopsie Human [1.3]
‐ Oribacterium sinus Saliva Human [1.3]
‐ Prevotella copri Causal? Gut Lumen Human
‐ Prevotella enoeca Saliva Human [1.6]
‐ Prevotella pallens Saliva Human [1.6]
‐ Prevotella Stool Human [1.4]
‐ Pyramidobacter piscolens Stool Human [1.2]
‐ Roseburia Causal? Gut Lumen Human
‐ Roseburia Stool Human [1.7]
‐ Selenomonas Saliva Human [1.6]
‐ Streptococcus infantis Stool Human [1.1]
‐ Subdoligranulum Causal? Gut Lumen Human
‐ Subdoligranulum Stool Human [1.7]
‐ TM7 Saliva Human [1.6]
‐ Veillonella Saliva Human [1.6]
‐ Veillonella Tissue biopsie Human [1.3]

↥ Metabolome

‐ Butyrate Ameliorative [1.5, 1.8]
‐ Lactate Stool Human [1.5]

↧ Metabolome

‐ Butyric acid Causal? Stool Human [1.5]
‐ Sulfate Stool Human [1.5]

Related Factor

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Subclass

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References

(1) [Link REMOVED] [2015] Behçet’s syndrome patients exhibit specific microbiome signature.

Author: MetaBiom
Identifier: 40000121
URL: https://www.metabiom.org/disease/20/behcets-disease
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients witch Behcet’s disease [2019] [Clinical Rheumatology] [Journal] [80001223]
[1.2] A metagenomic study of the gut microbiome in Behcet’s disease [2018] [Microbiome] [Journal] [80000793]
[1.3] The oral mucosal and salivary microbial community of Behcet’s syndrome and recurrent aphthous stomatitis [2015] [Journal of Oral Microbiology] [Journal] [80000423]
[1.4] Bifidobacteria abundance-featured gut microbiota compositional change in patients with Behcet’s Disease [2016] [PLOS ONE] [Journal] [80000346]
[1.5] Findings on the Relationship Between Intestinal Microbiome and Vasculitis [2022] [Frontiers in Cellular and Infection Microbiology] [Journal] [80002464]
[1.6] Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behcet’s disease [2016] [Clinical Immunology] [Journal] [80000770]
[1.7] Behçet’s syndrome patients exhibit specific microbiome signature [2015] [Autoimmunity Reviews] [Journal] [80000507]
[1.8] Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome [2021] [Research] [Circulation Research] [Journal] [80002329]

Disease ⇒ Behcet’s Disease {40000121}

Record Keys

Details

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Meta Information

Notes:

References Notes

Shared Reference Notes

Common References