Disease ⇒ Behcet’s Disease {40000121}

Record Keys


Type:
Disease
Parent:[  ]
Definition:
Behcet’s Disease

Details


Initialisation date:
2020-09-06
Other Terms:
BD, Behçet Disease

Links


Meta Information


MedDra ID:
10004213
MedDra Level:
pt
ICD:[  ]
Category:
Rheumatology, Immunology
Zone:[  ]
Mechanism:
Gut Inflammation, Leaky gut, Reduced SCFA

Notes:


- A significant decrease of butyrate production in patients was demonstrated (1)
- Lack of butyrate (antiinflamatory) > Lack of Mucin

Shared Reference Notes


  • [1.1] [#Butyrate
  • [1.2] [#Butyrate, #Lactate, #Lipopolysaccharide
    - These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and #Paraprevotella was observed in the BD-recipient group.
  • - a similar effect was observed by the administration of #Eubacterium rectale (a kind of #Butyrate-producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of #Colchicine, which is used to treat BD patients.
  • [1.3
    - Depleted #Dorea, #Blautia, #Coprococcus, #Erysipelotrichaceae and #Lachnospiraceae as well as enriched #Bilophila and #Stenotrophomonas were identified in BU patients.
  • - A peptide antigen (SteTDR) encoded by BU specifically enriched #Stenotrophomonas was identified to share homology with IRBP161-180. - Addition of the SteTDR peptide to the classical IRBP immunization protocol exacerbated EAU severity.
  • [1.4
    - Behcet’s disease > Stool samples were enriched with #Parabacteroides, sulphate-reducing bacteria #Bilophila and #Desulfovibrionaceae species. In addition, it was also noted that #Butyrate-producing bacteria #Clostridium and methanogens were reduced. - Transplantation of BD faeces in mice illustrated remarkable results in which gut integrity was breached due to decreased expression of tight junctions, with the subsequent effects of experimental uveitis.

References Notes


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Common References


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