Veillonellaceae ⇒ Veillonella {10000160}

Shared Reference Notes

• [1.1] [#Rheumatoid Arthritis] 
  - RA > Veillonella in saliva and tongue coating is at higher relative abundance compared to healthy controls.
• [1.2] [#Human milk nutrient fortifiers] 
  - babies fed HMBFs derived from their own mother’s milk had higher levels of Veillonella in their stools, which has been shown to help protect #Infants from developing #Asthma.
• [1.3] [#Diabetes Type 1, #Diabetes Type 2] 
  - Compared to the levels in non-diabetic individuals, diabetes patients exhibited a higher abundance of #Neisseria, TM7, #Gemella, #Eikenella, #Selenomonas, #Actinomyces, #Capnocytophaga, #Fusobacterium, #Aggregatibacter, Veillonella, and #Streptococcus genera and a lower abundance of Filifactor, Synergistetes, Tannerella, Eubacterium, Porphyromonas, and Treponema genera
• [1.4] [#Natural Skin Microbiome] [#Infants] 
  - Infant skin > 21 bacterial phyla with #Proteobacteria, #Firmicutes, #Actinobacteria, and #Bacteroidetes being the most abundant. - the relative abundance of #Burkholderiaceae and #Staphylococcus, highly abundant after birth, decreased progressively, to the benefit of newly colonizing taxa such as #Streptococcus, Veillonella, and #Enhydrobacter aerosaccus
• [1.5] [#Breast cancer] 
  - #Actinomyces and Veillonella were more abundant in breast tumors of #White Women than in those of Black women.
• [1.6] [#Alzheimer’s disease] 
  - The proinflammatory genus #Collinsella, identified as a risk factor for AD, was positively correlated with the APOE rs429358 risk allele in both samples. - 20 gut microbiota genera were initially identified as genetically associated with AD case/control status. Of these 20, three genera (#Eubacterium fissicatena as a protective factor, #Collinsella, and Veillonella as a risk factor) were independently significant in the replication sample.
• [1.7] [#Bipolar disorder, #Major depressive disorder, #Schizophrenia] 
  - MDD and SZ shared higher levels of #Escherichia/#Shigella and Veillonella whereas increased #Megasphaera and lower #Roseburia are common for BD and SZ.
• [1.8] [#High-protein diet] 
  - Excessive protein intake > causing the growth of protein fermenting bacteria as #Clostridium, #Desulfovibrio, #Peptostreptococcus, #Acidaminococcus, Veillonella, #Propionibacterium, Bacillus, #Bacteroides, #Staphylococcus, and other species of the #Proteobacteria family, and the loss of carbohydrate fermenting bacteria such as #Bacteroides, #Lactobacillus, #Bifidobacterium, #Prevotella, #Ruminococcus, #Roseburia, and #Faecalibacterium.
• [1.9] [#Human breast milk] 
  - #Phosphatidylserine has implications for brain development in #Infants > induce major shifts in #Bacillota (#Firmicutes): #Bacteroidota (#Bacteroidetes) ratio in human gut microbiomes. - #Clostridia and Veillonella genera > use #Phosphatidylserine as a substrate to catalyse phosphatidylethanolamine and plasmenylethanolamine, both by employing respective phospholipid decarboxylase activities.
• [#American Heart Association Diet, #Mediterranean Ketogen Diet] - Many of the top microbes associated with MMKD are of the Akkermansia taxa, while Veillonella, #Sutterella, and #Eubacteria are associated with AHAD. - higher relative abundances of #Akkermansia muciniphila on the MMKD and higher relative abundances of Veillonella sp. ACP1 on the AHAD
• [1.11] [#Primary sclerosing cholangitis] 
  - Veillonella extensively participates in a range of diseases associated with gastrointestinal microbial dysbiosis, for instance, hepatic and gall diseases (#Autoimmune hepatitis, #Alcoholic Hepatitis, #Biliary atresia, and PSC)
• [#Atherosclerosis] - the existence of Veillonella and #Streptococcus in atherosclerotic plaques, whose bacterial abundances positively correlated with their abundance in the oral cavity, indicating that oral Veillonella probably spread to extraoral organs via the circulatory system
• [#Clostridioides difficile] - Intestinal Veillonella attaches to the mucosa of the distal gut and positively coexists with Clostridioides in C. difficile colonization (CDC) patients
• [#Diabetes Type 2] - In periodontitis-associated type 2 diabetes (T2D), #Streptococcus and Veillonella are dominant in the symbiosis network, and microbial shifts may contribute to systemic inflammation and metabolic dysfunction
• [#Primary sclerosing cholangitis] [#Roseomonas mucosa, #Streptococcus salivarius] - Even in the early stages, PSC patients’ stool and mucosa significantly enrich oral pathogenic bacteria such as #Streptococcus, Veillonella, and #Actinomyces (#Streptococcus salivarius is an independent predictor of liver-related three-year mortality)
• - Veillonella is acid-sensitive, the abundance of Veillonella heightens when aldafermin-mediated suppressions of bile acid synthesis, particularly toxic #Bile Acids, are inhibited.
• [1.12] 
  - Higher proportions of #Bacteroidetes, namely #Prevotella, and lower proportions of #Firmicutes (#Streptococcus, Veillonella, #Gemella, and #Lactobacillaceae) are found in the duodenum compared with the jejunum.
• [#Natural Small intestine Microbiome] [#Escherichia coli] - At the genus level, bacteria highly abundant in the SI include #Lactobacillus, Veillonella, #Streptococcus, #Gemella, #Actinomyces, and E. coli.
• [1.13] [#Gastric carcinoma] 
  - The oral taxa #Neisseria, #Prevotella, and Veillonella had centralities in tumors with intestinal and mixed phenotypes and were associated with MUC13 overexpression, highlighting their role as potential drivers in MUC13 signaling in GC.
• [1.14] 
  - Anaerobes such as #Actinomyces, Veillonella and #Fusobacterium are less prevalent in Oral mucos and mostly present at subgingival sites
• [1.15] [#Exercise training] 
  - The genus Veillonella was positively correlated with extensive physical exercise in the post-race samples of marathon runners. - Veillonella inoculation into mice can significantly increase the exhaustive treadmill run time. - #Lactate is the sole carbon source for Veillonella.
• [1.16] [#Antibiotic Therapy] 
  - Postnatal antibiotic exposure > reduced relative abundance of #Lachnospiraceae (for example, #Dialister spp. and #Lachnospira spp.) and #Ruminococcaceae and increased relative abundance of Veillonella.
• [1.17] 
  - In healthy human stomach, the genera #Streptococcus, #Prevotella, Veillonella, #Rothia, and #Haemophilus were found to be predominant.
• [1.18] [#Candida albicans, #Streptococcus mutans] 
  - The presence of C. albicans would increase the abundance of #Streptococcus (particularly S. mutans), certain #Lactobacillus species, and salivary Veillonella and #Prevotella, and also increase the cariogenic virulence of biofilms
• [#Sjögren syndrome ] - the relative abundance of Veillonella in SS patients with higher DMFT was reported to be higher than the abundance in healthy controls
• - Veillonella is a gram-negative anaerobic coccus capable of fermenting organic acids such as malate and #Lactate.
• [1.19] 
  - Veillonella has also been found to be enriched in other inflammatory states such as #Autoimmune hepatitis and #Cystic fibrosis
• [#Colorectal cancer, #Lung cancer, #Pancreatic Cancer] [#Veillonella atypica] - Veillonella genus is usually more abundant in treatment-naïve patients with lung, pancreatic (Veillonella atypica) and colorectal #Cancer. - Furthermore, when comparing patients with advanced-stage #Cancer with and without weight loss, Veillonella is more abundant in those who lost weight.
• [#Clostridium cluster XVIII, #Clostridium clusters XIVa] - #Aspirin > differentially abundant > #Prevotella, Veillonella, Clostridium XIVa and Clostridium XVIII clusters
• [1.21] [#Bipolar disorder] 
  - Abundance of #Bacilli, #Lactobacillales and genus Veillonella were higher in BD patients than in HCs, while genus #Dorea was more abundant in HCs. - bacterial genera’ abundance in BD patients was strongly correlated with the severity of #Depression and inflammatory markers.
• [#Depression] [#TNF-alfa] - #Lipopolysaccharide (LPS) produced by Veillonella could stimulate the release of TNF-α, IL-1, #IL-6 and #IL-10 within Toll-like receptor (TLR) pathways
• Veillonella levels have been found to be higher in patients with #Irritable bowel syndrome
• [1.22] [#Postmenopausal] 
  - Gut #Bacteria that possess β-glucuronidase and/or β-galactosidase activity can metabolize #Estrogen including #Bifidobacterium, #Faecalibacterium, #Lactobacillus, Veillonella
• [1.23] [#Atherosclerosis] 
  - oral bacteria such as Veillonella spp and #Streptococcus spp found in the oral cavity, fecal samples, and carotid atherosclerotic plaque.9 Given the association between dental health and endothelial dysfunction and atherosclerotic disease,
• [1.24] [#Hepatocellular cancer] 
  - hepatocellular carcinoma > #Prevotella was enriched in patients with Progressive Disease. - hepatocellular carcinoma > #Lachnoclostridium, #Lachnospiraceae, and Veillonella were predominant in patients with objective responses.
• [1.25] [#Colorectal cancer, #Lung cancer, #Pancreatic Cancer] [#Veillonella atypica] 
  - Veillonella genus is usually more abundant in treatment-naïve patients with lung, pancreatic (Veillonella atypica) and colorectal #Cancer.
• [1.26] [#Diabetes Type 2] [#Short Chain Fatty Acid] 
  - A few examples of SCFA-producing bacteria are #Blautia hydrogenotrophica and #Marvinbryantia formatexigens, Veillonella spp., #Dialister spp etc. - Levels of SCFAs in T2DM patients are always lower than the healthy subjects. - The mechanism of action of SCFA includes promoting insulin secretion, improving insulin sensitivity, activating intestinal gluconeogenesis, increasing energy expenditure, reducing fat accumulation and inflammation. - They promote the production of satiety hormones and reduce the feeling of appetite.
• [1.27] [#Human breast milk, #Vaginally delivery] 
  - At 6 weeks postpartum, the composition and structure of gut microbiota of #Cesarean section-delivered (CSD) #Infants differed from those of vaginally delivered (VD) #Infants, with decreased #Bacteroides and #Escherichia-#Shigella and increased #Klebsiella, Veillonella, and #Enterococcus. - At 6 months postpartum, these delivery mode-induced microbial shifts were restored by exclusive breastfeeding, resulting in similar gut microbial profiles between VD and CSD #Infants who were exclusively breastfed and more variable gut microbial profiles between VD and CSD #Infants who were mixed fed.
• [1.28] 
  - Oral bacteria from genera #Capnocytophaga and Veillonella are reportedly present in increased amounts in #Lung cancer patients
• [#Oral squamous cell carcinoma] - Oral cancer and epithelial precursor lesions are also linked with bacteria from genera #Fusobacterium, Veillonella, #Actinomyces, #Clostridium, #Haemophilus, and #Enterobacteriaceae
• [1.29] 
  - patients with #Celiac Disease showed the abundance of #Streptococcus, #Lactobacillus, Veillonella, and #Allisonella species, while the abundance of #Ruminococcus, #Faecalibacterium, #Blautia, #Gemmiger, and #Anaerostipes was decreased.
• [#Bifidobacterium infantis] [#Para-cresol] - Antibitic resulted dysbiosis > Application of synbiotic #Bifidobacterium longum subspecies infantis (B. infantis), and #Human milk oligosaccharides (HMOs) > - increases in #Lactate-consuming Veillonella, faster #Acetate recovery, and changes in #Indolelactate and p-cresol #Sulfate, metabolites that impact host inflammatory status. - Veillonella co-cultured in vitro and in vivo with B. infantis and HMO converts #Lactate produced by B. infantis to #Propionate, an important mediator of host physiology.
• [1.31] 
  - presence of Veillonella is negatively correlated with #Asthma, #Bronchiolitis, and #Autism
• - the presence of Veillonella has been associated with the development of a healthy immune system in #Infants.
• [1.32] 
  - Patients with #Primary biliary cirrhosis were found to show enrichment of #Actinobacteria, #Lactobacillales, #Streptococcus, #Klebsiella and Veillonella
• [1.33] [#Veillonella atypica] [#Athletes, #Sport] 
  - increase in Veillonella relative abundance in marathon runners postmarathon. - Veillonella utilize #Lactate as their sole carbon source > at higher relative abundance postexercise > convert #Lactate to #Propionate. - V. atypica improves run time via its metabolic conversion of exercise-induced #Lactate into #Propionate, thereby identifying a natural, microbiome-encoded enzymatic process that enhances athletic performance. - intrarectal instillation of #Propionate in mouse is sufficient to reproduce the increased treadmill run time performance observed with V. atypica gavage.

References Notes