Veillonella ⇒ Cutibacterium acnes {10000230}

Shared Reference Notes

• [1.1] [#Staphylococcus epidermidis] 
  - #Acne > increased #Actinobacteria followed by #Firmicutes and #Proteobacteria, #Cutibacterium,#Staphylococcus and #Corynebacterium. - C. acnes > major species in terms of mean abundance, followed by #Staphylococcus epidermidis (S. epidermidis) and #Staphylococcus hominis (S. hominis);
• [1.2] [#Acne] 
  - An acneic Cutibacterium acnes strain as well as its porphyrins activate NRLP3 inflammasome assembly, while this was not observed with a non-acneic strain.
• [1.3] [#Atopic Dermatitis] 
  - AD subjects is characterized by reduced microbial richness, depletion of Cutibacterium acnes, #Dermacoccus and #Methylobacterium species.
• [1.4] [#Skin anatomy] 
  - C. acnes lineages coexist across an individual’s skin but not within the same pore
• [1.5] 
  - Cutibacterium acnes (formerly, #Propionibacterium acnes) is a skin-associated commensal that has been detected in the prostate of men with #Prostate cancer in several studies. - C. acnes can induce cell proliferation and the secretion of cytokines and chemokines such as IL-6 and IL-8
• [1.6] [#Propionic acid] [#Ultraviolet Exposure] 
• [1.7] 
  - #Lauric acid was shown to exert antimicrobial activity against Cutibacterium acnes
• [1.8] [#Antibiotic Therapy] 
  - a strain of #Staphylococcus capitis (S. capitis E12) that selectively inhibited growth of C. acnes with potency greater than antibiotics commonly used in the treatment of #Acne.
• [1.9] 
  - #Cutibacterium acnes secretes a thiopeptide RiPP called #Cutimycin that inhibits members of #Staphylococcus but does not affect the members of the genera #Corynebacterium and #Cutibacterium.
• [#Escherichia coli, #Staphylococcus aureus] - #RNAse7 showed higher inhibitory activity against E. Coli and Cutibacterium acnes compared to S. aureus
• [#Staphylococcus aureus] - Cutibacterium acnes secretes a lipase that converts triacylglycerols contained in sebum to #Propionic acid, which contributes to the acidification of the skin surface; a factor that limits the growth of S. aureus
• [#Natural Skin Microbiome] - Cutibacterium acnes associated with healthy skin were shown to activate the release of extracellular traps from specialized Th17 subsets
• - More than 4% of people whose blood came back positive for a bacterial DNA, it was for a dominant skin microbiota, i.e. Cutibacterium acnes.

References Notes